In enzymology, a glutaconate CoA-transferase (EC 2.8.3.12) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + (E)-glutaconate ${\displaystyle \rightleftharpoons }$ acetate + glutaconyl-1-CoA

Thus, the two substrates of this enzyme are acetyl-CoA and (E)-glutaconate, whereas its two products are acetate and glutaconyl-1-CoA.

This enzyme belongs to the family of transferases, specifically the CoA-transferases. The systematic name of this enzyme class is acetyl-CoA:(E)-glutaconate CoA-transferase. This enzyme participates in styrene degradation and butanoate metabolism.

• Buckel W, Dorn U, Semmler R (1981). "Glutaconate CoA-transferase from Acidaminococcus fermentans". Eur. J. Biochem. 118 (2): 315–21. doi:10.1111/j.1432-1033.1981.tb06404.x. PMID 6945182.