In enzymology, a succinate-hydroxymethylglutarate CoA-transferase (EC 2.8.3.13) is an enzyme that catalyzes the chemical reaction

succinyl-CoA + 3-hydroxy-3-methylglutarate ${\displaystyle \rightleftharpoons }$ succinate + (S)-3-hydroxy-3-methylglutaryl-CoA

Thus, the two substrates of this enzyme are succinyl-CoA and 3-hydroxy-3-methylglutarate, whereas its two products are succinate and (S)-3-hydroxy-3-methylglutaryl-CoA.

This enzyme belongs to the family of transferases, specifically the CoA-transferases. The systematic name of this enzyme class is succinyl-CoA:3-hydroxy-3-methylglutarate CoA-transferase. Other names in common use include hydroxymethylglutarate coenzyme A-transferase, and dicarboxyl-CoA:dicarboxylic acid coenzyme A transferase.

• Deana R, Rigoni F, Deana AD, Galzigna L (1981). "Submitochondrial localization and partial purification of the succinylCoA: 3-hydroxy-3-methylglutarate coenzyme A transferase from rat liver". Biochim. Biophys. Acta. 662 (1): 119–24. doi:10.1016/0005-2744(81)90231-x. PMID 6946836.