Azacosterol

Azacosterol
Ball-and-stick model of azacosterol
Clinical data
Other names20,25-Diazacholesterol; 20,25-Azacholesterol; Azasterol; Diazasterol; SC-12937; DAC; IMD-760; 17β-(3-(Dimethylamino)propyl)methyl-
amino)androst-5-en-3β-ol
Routes of
administration		By mouth
Identifiers
  • (3S,8R,9S,10R,13S,14S,17S)-17-[3-(dimethylamino)propyl-methylamino]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC25H44N2O
Molar mass388.640 g·mol−1
3D model (JSmol)
  • C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2N(C)CCCN(C)C)CC=C4[C@@]3(CC[C@@H](C4)O)C
  • InChI=1S/C25H44N2O/c1-24-13-11-19(28)17-18(24)7-8-20-21-9-10-23(25(21,2)14-12-22(20)24)27(5)16-6-15-26(3)4/h7,19-23,28H,6,8-17H2,1-5H3/t19-,20-,21-,22-,23-,24-,25-/m0/s1 checkY
  • Key:FMTFZYKYVZBISL-HUVRVWIJSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Azacosterol (INNTooltip International Nonproprietary Name), or azacosterol hydrochloride (USANTooltip United States Adopted Name) (brand name Ornitrol), also known as 20,25-diazacholesterol, is a cholesterol-lowering drug (hypocholesteremic), which was marketed previously, but has since been discontinued.[1][2][3] It is also an avian chemosterilant used to control pest pigeon populations via inducing sterility.[4] The drug is a sterol and derivative of cholesterol in which two carbon atoms have been replaced with nitrogen atoms.[5]

Azacosterol acts as an inhibitor of 24-dehydrocholesterol reductase (24-DHCR), preventing the formation of cholesterol from desmosterol.[4][6] Although it primarily acts to inhibit 24-DHCR, the drug also inhibits other steps in cholesterol biosynthesis.[6] The antifertility effects of the drug in birds are mediated by inhibition of steroid hormone production, steroid hormones being synthesized from cholesterol.[4] Due to prevention of the metabolism of desmosterol, the drug causes it to accumulate, in turn producing side effects such as hyperkeratosis, particularly of the palms and soles.[6]

See also

References

  1. ^ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 110–. ISBN 978-1-4757-2085-3.
  2. ^ Morton IK, Hall JM (31 October 1999). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 43–. ISBN 978-0-7514-0499-9.
  3. ^ William Andrew Publishing (22 October 2013). Pharmaceutical Manufacturing Encyclopedia (3rd ed.). Elsevier. pp. 463–. ISBN 978-0-8155-1856-3.
  4. ^ a b c Singh H, Kapoor VK, Paul D (January 1979). "Heterosteroids and drug research". Progress in Medicinal Chemistry. 16: 35–149. doi:10.1016/s0079-6468(08)70187-5. ISBN 9780720406672. PMID 95596.
  5. ^ Counsell RE, Klimstra PD, Ranney RE (November 1962). "Hypocholesterolemic Agents. III.1N-Methyl-N-(dialkylamino)alkyl-17β-aminoandrost-5-en-3β-ol Derivatives". Journal of Medicinal and Pharmaceutical Chemistry. 91 (6): 1224–33. doi:10.1021/jm01241a014. PMID 14056455.
  6. ^ a b c Williams ML (21 January 2016). "Lipids in normal and pathological desquamation". In Elias PM (ed.). Advances in Lipid Research: Skin Lipids. Elsevier. pp. 218–220. ISBN 978-1-4832-1545-7.


Stub icon

This drug article relating to the cardiovascular system is a stub. You can help Wikipedia by expanding it.

Read other articles:

L'Inconnue

Short story by French author Guy de Maupassant, published in 1885 For other uses, see Lucy Virginia French. This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: L'Inconnue – news · newspapers · books · scholar · JSTOR (September 2014) (Learn how and when to remove this template message) La ConfidenceShort story b...

 

Go Go Squid!

Go Go Squid!Poster Go Go Squid!GenreKomedi romantiseSportBerdasarkanStewed Squid with Honey oleh Mo Bao Fei BaoDitulis olehMo Bao Fei BaoSutradaraLi JingrongXiang XujingPemeranYang ZiLi XianLagu pembukaWu Ming Zhi Bei (无名之辈, Seseorang Tanpa Nama) oleh Chen XueranLagu penutupNiu Nai Mian Bao (牛奶面包, Roti Susu) oleh Yang ZiNegara asalTiongkokBahasa asliMandarinJmlh. musim1Jmlh. episode41 (daftar episode)ProduksiLokasi produksiShanghai, SanyaDurasi45 menitRumah produksiShanghai G...

 

Football in Peru

Overview of association football in Peru See also: Peru national football team, Peru women's national football team, Peru national under-20 football team, and Peru national under-17 football team Football in PeruCountryPeruGoverning bodyPeruvian Football FederationNational team(s)PeruFirst played1867National competitions FIFA World Cup Copa AméricaClub competitions List League: Peruvian Primera División Peruvian Segunda División Cups: Torneo del Inca Copa Bicentenario International competi...

Panitan, Capiz

Peta menunjukan lokasi Panitan Panitan adalah munisipalitas yang terletak di provinsi Capiz, Filipina. Pada tahun 2000, munisipalitas ini memiliki populasi sebesar 37.458 jiwa atau 7.073 rumah tangga. Pembagian wilayah Secara politis Panitan terbagi menjadi 26 barangay, yaitu: Agbabadiang Agkilo Agloway Ambilay Bahit Balatucan Banga-an Cabugao Cabangahan Cadio Cala-an Capagao Cogon Conciencia Ensenagan Intampilan Pasugue Poblacion Ilawod Poblacion Ilaya Quios Salocon Tabuc Norte Tabuc Sur Tim...

 

Daftar masjid di Riau

Berikut adalah daftar masjid yang ada di Riau, Indonesia Masjid Raya Pekanbaru, Riau Masjid Agung An-Nur, Riau Masjid Jami Air Tiris, Riau Masjid Agung Al-Manan, Riau Masjid Istiqomah, Riau Masjid Sultan Syarif Hasyim, Riau Masjid Ar-Rahman, Riau Galeri Referensi Pranala luar lbsMasjid di IndonesiaSumatraAceh · Sumatera Utara · Sumatera Barat · Riau · Kepulauan Riau · Jambi · Bengkulu · Kepulauan Bangka Belitung ...

 

周處除三害 (電影)

周處除三害The Pig, The Snake and The Pigeon正式版海報基本资料导演黃精甫监制李烈黃江豐動作指導洪昰顥编剧黃精甫主演阮經天袁富華陳以文王淨李李仁謝瓊煖配乐盧律銘林孝親林思妤保卜摄影王金城剪辑黃精甫林雍益制片商一種態度電影股份有限公司片长134分鐘产地 臺灣语言國語粵語台語上映及发行上映日期 2023年10月6日 (2023-10-06)（台灣） 2023年11月2日 (2023-11-02)（香�...

2020年夏季奧林匹克運動會波蘭代表團

2020年夏季奥林匹克运动会波兰代表團波兰国旗IOC編碼POLNOC波蘭奧林匹克委員會網站olimpijski.pl（英文）（波兰文）2020年夏季奥林匹克运动会（東京）2021年7月23日至8月8日（受2019冠状病毒病疫情影响推迟，但仍保留原定名称）運動員206參賽項目24个大项旗手开幕式：帕维尔·科热尼奥夫斯基（游泳）和马娅·沃什乔夫斯卡（自行车）[1]闭幕式：卡罗利娜·纳亚（皮划艇）&#...

 

Common ringed plover

Species of bird Common ringed plover AdultCalls recorded in Norfolk, England Conservation status Least Concern  (IUCN 3.1)[1] Scientific classification Domain: Eukaryota Kingdom: Animalia Phylum: Chordata Class: Aves Order: Charadriiformes Family: Charadriidae Genus: Charadrius Species: C. hiaticula Binomial name Charadrius hiaticulaLinnaeus, 1758 The common ringed plover or ringed plover (Charadrius hiaticula) is a small plover that breeds across much of northern Eurasia, a...

 

Hans Hateboer

Dutch footballer (born 1994) Hans Hateboer Hateboer with Atalanta in 2017Personal informationDate of birth (1994-01-09) 9 January 1994 (age 30)Place of birth Beerta, NetherlandsHeight 1.85 m (6 ft 1 in)[1]Position(s) Right-backTeam informationCurrent team AtalantaNumber 33Youth career THOS Veendam GroningenSenior career*Years Team Apps (Gls)2013–2017 Groningen 87 (1)2017– Atalanta 187 (8)International career‡2014 Netherlands U20 3 (0)2014–2016 Netherlands U...

مقاطعة كالهاون (آيوا)

  لمعانٍ أخرى، طالع مقاطعة كالهاون (توضيح). مقاطعة كالهاون     الإحداثيات 42°23′10″N 94°38′50″W / 42.386111111111°N 94.647222222222°W / 42.386111111111; -94.647222222222   [1] تاريخ التأسيس 15 يناير 1851  سبب التسمية جون كالهون[2]  تقسيم إداري  البلد الولايات المتحدة[3] ...

 

Torrella

Municipality in Valencian Community, SpainTorrellaMunicipality Coat of armsTorrellaLocation in SpainCoordinates: 38°59′20″N 0°34′18″W / 38.98889°N 0.57167°W / 38.98889; -0.57167Country SpainAutonomous community Valencian CommunityProvinceValenciaComarcaCosteraJudicial districtXàtivaGovernment • AlcaldeFrancisco Moreno GayáArea • Total1.1 km2 (0.4 sq mi)Elevation135 m (443 ft)Population (2018)...

 

Angélico

South African professional wrestler Parts of this article (those related to All Elite Wrestling) need to be updated. The reason given is: Only has up to 2019 at present. Please help update this article to reflect recent events or newly available information. (February 2023) AngélicoAngélico in November 2015Birth nameAdam BridleBorn (1987-05-07) 7 May 1987 (age 37)Johannesburg, Transvaal,South AfricaProfessional wrestling careerRing name(s)Adam Angel[1]Adam BridleAdam CroftAngé...

Honda Center

Honda CenterHonda Ponda, The Ponda Center, The Pond Veduta esterna dell'Honda Center nel 2007. Informazioni generaliStato Stati Uniti Ubicazione2685 E. Katella AvenueAnaheim, California 92806 Inizio lavorigiugno 1991 Inaugurazione19 giugno 1993 ProprietarioCittà di Anaheim ProgettoHOK Sport Prog. strutturaleThornton Tomasetti Intitolato aHonda Informazioni tecnichePosti a sedereWrestling: 19776Pallacanestro: 17600Hockey: 17174Concerti: 18325Teatro: 8400 Coperturasi Uso e beneficiariHock...

 

National Party (United States)

Short-lived American political party National Party Founded1917 (1917)Dissolved1919 (1919)IdeologySocial democracyProgressivismPro-war patriotismPolitical positionCenter-leftPolitics of United StatesPolitical partiesElections This article is part of a series onSocialismin the United States HistoryUtopian socialism Bishop Hill Commune Brook Farm Icarians Jonestown Looking Backward New Harmony Oneida Community Progressive Era 1877 St. Louis general strike 1912 Lawrence textile st...

 

Jupiter Icy Moons Explorer

European Space Agency spacecraft For the proposed NASA spacecraft, see Jupiter Icy Moons Orbiter. Jupiter Icy Moons ExplorerArtist's impression of the Juice spacecraftNamesJuice, JUICEMission typePlanetary scienceOperatorESACOSPAR ID2023-053A SATCAT no.56176Mission durationCruise phase: 8 yearsScience phase: 3.5 yearsElapsed: 1 year, 2 months and 1 day Spacecraft propertiesManufacturerAirbus Defence and SpaceLaunch mass6,070 kg (13,380 lb)[1]Dry mass2,420 ...

Old Main, Goethean Hall, and Diagnothian Hall

United States historic placeOld Main, Goethean Hall, and Diagnothian HallU.S. National Register of Historic Places Old Main, 1910Show map of PennsylvaniaShow map of the United StatesLocationFranklin and Marshall College campus, Lancaster, PennsylvaniaCoordinates40°2′42″N 76°19′14″W / 40.04500°N 76.32056°W / 40.04500; -76.32056Area2 acres (0.81 ha)Built1854-1856, 1857ArchitectDixon, Balburnie, & DixonArchitectural styleGothic RevivalNRHP r...

 

Holden Woodville Plant

Automobile manufacturing facility owned by Australian automobile company holden The Holden Woodville Plant was a manufacturing facility owned by the Australian motor vehicle manufacturer Holden situated in Cheltenham, South Australia, a suburb of Adelaide. Etymology Although the plant is named after the Australian town of Woodville, South Australia, the actual plant was located in the adjacent suburb of Cheltenham.[1] History In 1923,[2] Holden's Motor Body Builders Ltd (HMBB)...

 

قصر صبحا

قصر صبحامعلومات عامةنوع المبنى قصر تاريخيالمكان [[الهدار البلد  السعودية ، الأفلاجتعديل - تعديل مصدري - تعديل ويكي بيانات قصر صبحا يقع في الهدار بمنطقة الأفلاج، والهدار أبعد قرى الأفلاج حيث تبعد حوالي 110 كم عن مدينة ليلى في اتجاه الجنوب الغربي، ويبعد حوالي 75 كم من البديع �...

Thomas Hoving

American museum executive (1931-2009) Thomas HovingDirector of the Metropolitan Museum of ArtIn office1967–1977Preceded byJames J. RorimerSucceeded byPhilippe de MontebelloParks Commissioner of New York CityIn office1966–1967Appointed byJohn V. LindsayPreceded byNewbold MorrisSucceeded byAugust Heckscher II Personal detailsBornThomas Pearsall Field Hoving(1931-01-15)January 15, 1931New York City, New York, U.S.DiedDecember 10, 2009(2009-12-10) (aged 78)New York City, New York, U.S.Sp...

 

Уильямсон, Джек

В Википедии есть статьи о других людях с фамилией Уильямсон. Джек Уильямсонангл. Jack Williamson Имя при рождении Джон Стюарт Уильямсон Псевдонимы Уилл Стюарт Дата рождения 29 апреля 1908(1908-04-29)[1][2][…] Место рождения Бисби, Аризона, США Дата смерти 10 ноября 2006(2006-11-10)[3]...