Aldrin

For other uses, see Aldrin (disambiguation).
Aldrin
Aldrin
Names
Preferred IUPAC name
(1R,4S,4aS,5S,8R,8aR)-1,2,3,4,10,10-Hexachloro-1,4,4a,5,8,8a-hexahydro-1,4:5,8-dimethanonaphthalene
Other names
HHDN[1]
octalene[1]
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard 100.005.652 Edit this at Wikidata
EC Number
  • 206-215-8
KEGG
RTECS number
  • IO2100000
UNII
UN number 2762, 2761
  • InChI=1S/C12H8Cl6/c13-8-9(14)11(16)7-5-2-1-4(3-5)6(7)10(8,15)12(11,17)18/h1-2,4-7H,3H2/t4-,5+,6+,7-,10+,11- checkY
    Key: QBYJBZPUGVGKQQ-SJJAEHHWSA-N checkY
  • InChI=1/C12H8Cl6/c13-8-9(14)11(16)7-5-2-1-4(3-5)6(7)10(8,15)12(11,17)18/h1-2,4-7H,3H2/t4-,5+,6+,7-,10+,11-
    Key: QBYJBZPUGVGKQQ-SJJAEHHWBI
  • ClC4(Cl)[C@@]2(Cl)C(/Cl)=C(/Cl)[C@]4(Cl)[C@@H]3[C@@H]\1C[C@@H](/C=C/1)[C@H]23
Properties
C12H8Cl6
Molar mass 364.90 g·mol−1
Appearance Colorless solid
Density 1.60 g/mL[1]
Melting point 104 °C (219 °F; 377 K)
slightly soluble (0.003%)[1]
Vapor pressure 7.5 × 10−5 mmHg @ 20 °C
Pharmacology
Legal status
  • AU: S6 (Poison)
Hazards
Occupational safety and health (OHS/OSH):
Main hazards
 Toxic and is a suspected human carcinogen[1]
GHS labelling:
GHS06: ToxicGHS08: Health hazardGHS09: Environmental hazard
Danger
H300, H301, H310, H311, H351, H372, H410
P201, P202, P260, P262, P264, P270, P273, P280, P281, P301+P310, P302+P350, P302+P352, P308+P313, P310, P312, P314, P321, P322, P330, P361, P363, P391, P405, P501
NFPA 704 (fire diamond)
NFPA 704 four-colored diamondHealth 4: Very short exposure could cause death or major residual injury. E.g. VX gasFlammability 0: Will not burn. E.g. waterInstability 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g. liquid nitrogenSpecial hazards (white): no code
4
0
0
Flash point 66 °C (151 °F; 339 K)
Lethal dose or concentration (LD, LC):
50 mg/kg (rabbit, oral)
33 mg/kg (guinea pig, oral)
39 mg/kg (rat, oral)
44 mg/kg (mouse, oral)[2]
5.8 mg/m3 (rat, 4 hr)[2]
NIOSH (US health exposure limits):
PEL (Permissible)
 TWA 0.25 mg/m3 [skin][1]
REL (Recommended)
 Ca TWA 0.25 mg/m3 [skin][1]
IDLH (Immediate danger)
 25 mg/m3[1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
checkY verify (what is checkY☒N ?)

Aldrin is an organochlorine insecticide that was widely used until the 1990s, when it was banned in most countries. Aldrin is a member of the so-called "classic organochlorines" (COC) group of pesticides. COCs enjoyed a very sharp rise in popularity during and after World War II. Other noteworthy examples of COCs include dieldrin and DDT.[3] After research showed that organochlorines can be highly toxic to the ecosystem through bioaccumulation, most were banned from use. Before the ban, it was heavily used as a pesticide to treat seed and soil. Aldrin and related "cyclodiene" pesticides (a term for pesticides derived from Hexachlorocyclopentadiene) became notorious as persistent organic pollutants.[4]

Structure and Reactivity

Pure aldrin takes form as a white crystalline powder. Though it is not soluble in water (0.003% solubility), aldrin dissolves very well in organic solvents, such as ketones and paraffins.[5] Aldrin decays very slowly once released into the environment. Though it is rapidly converted to dieldrin by plants and bacteria, dieldrin maintains the same toxic effects and slow decay of aldrin.[6] Aldrin is easily transported through the air by dust particles. Aldrin does not react with mild acids or bases and is stable in an environment with a pH between 4 and 8. It is highly flammable when exposed to temperatures above 200 °C[7] In the presence of oxidizing agents aldrin reacts with concentrated acids and phenols.

Synthesis

Aldrin is not formed in nature. It is named after the German chemist Kurt Alder, one of the coinventors of this kind of reaction. Aldrin is synthesized by combining hexachlorocyclopentadiene with norbornadiene in a Diels-Alder reaction to give the adduct.[8] In 1967, the composition of technical-grade aldrin was reported to consist of 90.5% of hexachlorohexahydrodimethanonaphthalene (HHDN).[6]

Synthesis of aldrin via a Diels-Alder reaction

Similarly, an isomer of aldrin, known as isodrin, is produced by reaction of hexachloronobornadiene with cyclopentadiene.[9] Isodrin is also produced as a byproduct of aldrin synthesis, with technical-grade aldrin containing about 3,5% isodrin.[6]

An estimated 270 million kilograms of aldrin and related cyclodiene pesticides were produced between 1946 and 1976.[10] The estimated production volume of aldrin in the US peaked in the mid-1960s at about 18 million pounds a year and then declined.[11]

Available forms

There are multiple available forms of aldrin. One of these is the isomer isodrin, which cannot be found in nature, but needs to be synthesized like aldrin. When aldrin enters the human body or the environment it is rapidly converted to dieldrin. Degradation by ultraviolet radiation or microbes can convert dieldrin to photodieldrin and aldrin to photoaldrin.[6]

Mechanism of action

Even though many toxic effects of aldrin have been discovered, the exact mechanisms underlying the toxicity are yet to be determined. The only toxic aldrin induced process that is largely understood is that of neurotoxicity.

Neurotoxicity

One of the effects that intoxication with aldrin gives rise to is neurotoxicity. Studies have shown that aldrin stimulates the central nervous system (CNS), which may cause hyperexcitation and seizures.[12] This phenomenon exerts its effect through two different mechanisms.

One of the mechanisms uses the ability of aldrin to inhibit brain calcium ATPases.[13] These ion pumps relieve the nerve terminal from calcium by actively pumping it out. However, when aldrin inhibits these pumps, the intracellular calcium levels rise. This results in an enhanced neurotransmitter release.

The second mechanism makes use of aldrin's ability to block gamma-aminobutyric acid (GABA) activity.[14] GABA is a major inhibitory neurotransmitter in the central nervous system. Aldrin induces neurotoxic effects by blocking the GABAA receptor-chloride channel complex. By blocking this receptor, chloride is unable to move into the synapse, which prevents hyperpolarization of neuronal synapses. Therefore, the synapses are more likely to generate action potentials.

Metabolism

The metabolism of oral aldrin exposure has not been studied in humans. However, animal studies are able to provide an extensive overview of the metabolism of aldrin. This data can be related to humans.

Biotransformation of aldrin starts with epoxidation of aldrin by mixed-function oxidases (CYP-450),[15] which forms dieldrin. This conversion happens mainly in the liver. Tissues with low CYP-450 expression use the prostaglandin endoperoxide synthase (PES) instead.[16] This oxidative pathway bisdioxygenises the arachidonic acid to prostaglandin G2 (PGG2). Subsequently, PGG2 is reduced to prostaglandin H2 (PGH2) by hydroperoxidase.

Dieldrin can then be directly oxidized by cytochrome oxidases, which forms 9-hydroxydieldrin. An alternative for oxidation involves the opening of the epoxide ring by epoxide hydrases, which forms the product 6,7-trans-dihydroxydihydroaldrin.[17] Both products can be conjugated to form 6,7-trans-dihydroxydihydroaldrin glucuronide and 9-hydroxydieldrin glucuronide, respectively. 6,7-trans-dihydroxydihydroaldrin can also be oxidized to form aldrin dicarboxylic acid.[18][19]

Efficacy and side effects

Considering the toxicokinetics of aldrin in the environment, the efficacy of the compound has been determined. In addition, the adverse effects after exposure to aldrin are demonstrated, indicating the risk regarding the compound.

Efficacy

The ability of aldrin, in its use for the control of termites, is examined in order to determine the maximum response when applied. In 1953 US researchers tested aldrin and dieldrin on terrains with rats known to carry chiggers, at a rate of 2.25 pounds per acre (2.52 kg/ha). The aldrin and dieldrin treatment demonstrated a decrease of 75 times less chiggers on rats for dieldrin treated terrains and 25 times less chiggers on the rats when treated with aldrin. The aldrin treatment indicate a high productivity, especially in comparison to other insecticides that were used at the time, such as DDT, sulfur or lindane.[20]

Adverse effects

Exposure of aldrin to the environment leads to the localization of the chemical compound in the air, soil, and water.[6] Aldrin gets changed quickly to dieldrin and that compound degrades slowly, which accounts for aldrin concentrations in the environment around the primary exposure and in the plants.[21] These concentrations can also be found in animals, which eat contaminated plants or animals that reside in the contaminated water. This biomagnification can lead to a high concentrations in their fat.

There are some reported cases of workers who developed anemia after multiple dieldrin exposures. However the main adverse effect of aldrin and dieldrin is in relationship to the central nervous system.[6] The accumulated levels of dieldrin in the body were believed to lead to convulsions.[22] Besides that other symptoms were also reported like headaches, nausea and vomiting, anorexia, muscle twitching and myoclonic jerking and EEG distortions. In all these cases removal of the source of exposure to aldrin/dieldrin led to a rapid recovery.[23]

Toxicity

The toxicity of aldrin and dieldrin is determined by the results of several animal studies. Reports of a significant increase in workers death in relation to aldrin has not been found, although death by anemia is reported in some cases after multiple exposure to aldrin. Immunological tests linked an antigenic response to erythrocytes coated with dieldrin in those cases.[24] Direct dose-response relations being a cause for death are yet to be examined.

The NOAEL that was derived from rat studies:[6]

  • The minimal risk level at acute oral exposure to aldrin is 0.002 mg/kg/day.
  • The minimal risk level at intermediate exposure to dieldrin is 0.0001 mg/kg/day.
  • The minimal risk level at chronic exposure to aldrin is 0.00003 mg/kg/day.
  • The minimal risk level at chronic exposure to dieldrin is 0.00005 mg/kg/day.

In addition to these studies, breast cancer risk studies were performed demonstrating a significant increased breast cancer risk. After comparing blood concentrations to number of lymph nodes and tumor size a 5-fold higher risk of death was determined, comparing the highest quartile range in the research to the lower quartile range.[25]

Effects on animals

Most of the animal studies done with aldrin and dieldrin used rats. High doses of aldrin and dieldrin demonstrated neurotoxicity, but in multiple rat studies also showed a unique sensitivity of the mouse liver to dieldrin induced hepatocarcinogenicity.[26] Furthermore, aldrin treated rats demonstrated an increased post-natal mortality, in which adults showed an increased susceptibility to the compounds compared to children in rats.[27]

Environmental impact and regulation

Like related polychlorinated pesticides, aldrin is highly lipophilic. Its solubility in water is only 0.027 mg/L, which exacerbates its persistence in the environment. It was banned by the Stockholm Convention on Persistent Organic Pollutants. In the U.S., aldrin was cancelled in 1974. The substance is banned from use for plant protection by the EU.[28]

Safety and environmental aspects

Aldrin has rat LD50 of 39 to 60 mg/kg (oral in rats). For fish however, it is extremely toxic, with an LC50 of 0.006–0.01 for trout and bluegill.[4]

In the US, aldrin is considered a potential occupational carcinogen by the Occupational Safety and Health Administration and the National Institute for Occupational Safety and Health; these agencies have set an occupational exposure limit for dermal exposures at 0.25 mg/m3 over an eight-hour time-weighted average.[29] Further, an IDLH limit has been set at 25 mg/m3, based on acute toxicity data in humans to which subjects reacted with convulsions within 20 minutes of exposure.[30]

It is classified as an extremely hazardous substance in the United States as defined in Section 302 of the U.S. Emergency Planning and Community Right-to-Know Act (42 U.S.C. 11002), and is subject to strict reporting requirements by facilities which produce, store, or use it in significant quantities.[31]

References

  1. ^ a b c d e f g h NIOSH Pocket Guide to Chemical Hazards. "#0016". National Institute for Occupational Safety and Health (NIOSH).
  2. ^ a b "Aldrin". Immediately Dangerous to Life or Health Concentrations (IDLH). National Institute for Occupational Safety and Health (NIOSH).
  3. ^ Zitko, Vladimir (2003), "Chlorinated Pesticides: Aldrin, DDT, Endrin, Dieldrin, Mirex", in Fiedler, H. (ed.), Persistent Organic Pollutants, The Handbook of Environmental Chemistry, vol. 3O, Springer Berlin Heidelberg, pp. 47–90, doi:10.1007/10751132_4, ISBN 9783540479321
  4. ^ a b Robert L. Metcalf "Insect Control" in Ullmann’s Encyclopedia of Industrial Chemistry" Wiley-VCH, Weinheim, 2002. doi:10.1002/14356007.a14_263
  5. ^ "International Programme on Chemical Safety, Poisons Information Monograph 573 Aldrin". www.inchem.org. Retrieved 2019-04-06.
  6. ^ a b c d e f g "ATSDR (2022). Toxicological profile for aldrin/dieldrin" (PDF).
  7. ^ PubChem. "Aldrin". pubchem.ncbi.nlm.nih.gov. Retrieved 2019-04-06.
  8. ^ Jubb, A. H. (1975). Basic Organic Chemistry, Part 5 Industrial products. London: Wiley. ISBN 0-471-85014-4.
  9. ^ Bird, C. W.; Cookson, R. C.; Crundwell, E. (1961). "946. Cyclisations and rearrangements in the isodrin?aldrin series". Journal of the Chemical Society (Resumed): 4809–4816. doi:10.1039/JR9610004809.
  10. ^ Mrema, Ezra J.; Rubino, Federico M.; Colosio, Claudio (2013), Simeonov, Lubomir I.; Macaev, Fliur Z.; Simeonova, Biana G. (eds.), "Obsolete Pesticides – A Threat to Environment, Biodiversity and Human Health", Environmental Security Assessment and Management of Obsolete Pesticides in Southeast Europe, NATO Science for Peace and Security Series C: Environmental Security, Dordrecht: Springer Netherlands, pp. 1–21, doi:10.1007/978-94-007-6461-3_1, ISBN 978-94-007-6460-6
  11. ^ Jorgensen, JL. (2001). "Aldrin and dieldrin: A review of research on their production environmental deposition and fate, bioaccumulation, toxicology, and epidemiology in the United States". Environmental Health Perspectives. 109 (Suppl.) (Suppl 1): 113–39. doi:10.1289/ehp.01109s1113. PMC 1240548. PMID 11250811.
  12. ^ Gupta (May 1975). "Neurotoxicity of chronic chlorinated hydrocarbon insecticide poisoning: A clinical and electroencephalographic study in man". The Indian Journal of Medical Research. 63 (4): 601–606. PMID 55381.
  13. ^ Mehrotra, B. D.; Ravichandra Reddy, S.; Desaiah, D. (1988). "Effect of subchronic dieldrin treatment on calmodulin-regulated Ca2+ pump activity in rat brain". Journal of Toxicology and Environmental Health. 25 (4): 461–469. Bibcode:1988JTEHA..25..461M. doi:10.1080/15287398809531224. ISSN 0098-4108. PMID 2974087.
  14. ^ Glotfelty, Dwight E. (1978-09-01). "The Atmosphere as a Sink for Applied Pesticides". Journal of the Air Pollution Control Association. 28 (9): 917–921. doi:10.1080/00022470.1978.11490579. ISSN 0002-2470.
  15. ^ Wong, D. T.; Terriere, L. C. (March 1965). "Epoxidation of aldrin, isodrin, and heptachlor by rat liver microsomes". Biochemical Pharmacology. 14 (3): 375–377. doi:10.1016/0006-2952(65)90210-8. ISSN 0006-2952. PMID 14314340.
  16. ^ Lang, B.; Frei, K.; Maier, P. (1986-10-15). "Prostaglandin synthase dependent aldrin epoxidation in hepatic and extrahepatic tissues of rats". Biochemical Pharmacology. 35 (20): 3643–3645. doi:10.1016/0006-2952(86)90640-4. ISSN 0006-2952. PMID 3094543.
  17. ^ Iatropoulos, M. J. (December 1975). "Absorption, transport and organotropism of dichlorobiphenyl (DCB), dieldrin, and hexachlorobenzene (HCB) in rats". Environmental Research. 10 (3): 384–389. Bibcode:1975ER.....10..384I. doi:10.1016/0013-9351(75)90033-X. ISSN 0013-9351. PMID 1213019.
  18. ^ Baldwin, M. K.; Robinson, J.; Parke, D. V. (June 1972). "A comparison of the metabolism of HEOD (dieldrin) in the CF1 mouse with that in the CFE rat". Food and Cosmetics Toxicology. 10 (3): 333–351. doi:10.1016/S0015-6264(72)80252-9. ISSN 0015-6264. PMID 5045677.
  19. ^ Hutson, D. H. (December 1976). "Comparative metabolism of dieldrin in the rat (CFE) and in two strains of mouse (CF1 and LACG)". Food and Cosmetics Toxicology. 14 (6): 577–591. doi:10.1016/S0015-6264(76)80012-0. ISSN 0015-6264. PMID 1017774.
  20. ^ Traub, Robert; Newson, Harold D.; Walton, Bryce C.; Audy, J. R. (1954-06-01). "Efficacy of Dieldrin and Aldrin in Area Control of the Chigger Vectors of Scrub Typhus". Journal of Economic Entomology. 47 (3): 429–435. doi:10.1093/jee/47.3.429. ISSN 1938-291X.
  21. ^ Castro, Teresita F.; Yoshida, Tomio. (November 1971). "Degradation of organochlorine insecticides in flooded soils in the Philippines". Journal of Agricultural and Food Chemistry. 19 (6): 1168–1170. doi:10.1021/jf60178a041. ISSN 0021-8561. PMID 5132645.
  22. ^ Versteeg, J. P. J.; Jager, K. W. (1973-04-01). "Long-term occupational exposure to the insecticides aldrin dieldrin, endrin, and telodrin". Occupational and Environmental Medicine. 30 (2): 201–202. doi:10.1136/oem.30.2.201. ISSN 1351-0711. PMC 1009505. PMID 4703092.
  23. ^ Avar, P.; Czegledi-Janko, G. (1970-07-01). "Occupational exposure to aldrin: clinical and laboratory findings". Occupational and Environmental Medicine. 27 (3): 279–282. doi:10.1136/oem.27.3.279. ISSN 1351-0711. PMC 1009144. PMID 4194425.
  24. ^ Krzystyniak, Krzystof; Hugo, Patrice; Flipo, Denis; Fournier, Michel (September 1985). "Increased susceptibility to mouse hepatitis virus 3 of peritoneal macrophages exposed to dieldrin". Toxicology and Applied Pharmacology. 80 (3): 397–408. doi:10.1016/0041-008x(85)90384-9. ISSN 0041-008X. PMC 7173191. PMID 2994259.
  25. ^ Høyer, Annette Pernille; Jørgensen, Torben; Brock, John W.; Grandjean, Philippe (March 2000). "Organochlorine exposure and breast cancer survival". Journal of Clinical Epidemiology. 53 (3): 323–330. doi:10.1016/s0895-4356(99)00165-1. ISSN 0895-4356. PMID 10760644.
  26. ^ Black, A. M. S. (November 1974). "Self Poisoning with Dieldrin: A Case Report and Pharmacokinetic Discussion". Anaesthesia and Intensive Care. 2 (4): 369–374. doi:10.1177/0310057x7400200413. ISSN 0310-057X. PMID 4614682.
  27. ^ Virgo, Bruce B.; Bellward, Gail D. (October 1975). "Effect of Dietary Dieldrin on the Liver and Drug Metabolism in the Female Swiss-Vancouver Mouse". Canadian Journal of Physiology and Pharmacology. 53 (5): 903–911. doi:10.1139/y75-124. ISSN 0008-4212. PMID 1201496.
  28. ^ Chemicals Regulation Directorate. "Banned and Non-Authorised Pesticides in the United Kingdom". Retrieved 1 December 2009.
  29. ^ Centers for Disease Control and Prevention (4 April 2011). "Aldrin". NIOSH Pocket Guide to Chemical Hazards. Retrieved 13 November 2013.
  30. ^ Centers for Disease Control and Prevention (May 1994). "Aldrin". Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs). Retrieved 13 November 2013.
  31. ^ 40 C.F.R.: Appendix A to Part 355—The List of Extremely Hazardous Substances and Their Threshold Planning Quantities (PDF) (July 1, 2008 ed.). Government Printing Office. Archived from the original (PDF) on February 25, 2012. Retrieved October 29, 2011.

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Ethnic group Ethnic group British diasporaTotal populationEstimated at 200 million[1]Regions with significant populationsUnited States109,531,643(up to 33% of population)[A][4]Australia19,301,379(up to 76% of population)[B][5]Canada17,325,860(up to 48% of population)[C][7]New Zealand3,372,708(up to 70.2% of population)[D][9]South Africa1,600,000 (4% of population)[10]Chile700,000-850,000(4% of population)[11&#...

 

Tiny Tim (A Christmas Carol)

Fictional character from Dickens' novella A Christmas Carol Fictional character Tiny Tim CratchitA Christmas Carol characterBob Cratchit and Tiny Tim Cratchit as depicted in an illustration by Fred BarnardCreated byCharles DickensPortrayed bySee belowIn-universe informationNicknameTiny TimGenderMaleFamilyBob (father)Mrs Cratchit (named Emily in some adaptations)(mother) Martha Cratchit Belinda Cratchit Peter Cratchit Unnamed sister Unnamed brother (siblings) Tiny Tim Cratchit is a fictional c...

 

T.J. Miller

T. J. MillerLahirTodd Joseph Miller4 Juni 1981 (umur 43)Denver, Colorado, Amerika SerikatPekerjaanAktor/KomedianTahun aktif2007–sekarang Todd Joseph Miller (lahir 4 Juni 1981) lebih dikenal sebagai T. J. Miller adalah aktor dan komedian asal Amerika Serikat. Filmografi Judul Tahun Peran Catatan Carpoolers 2007-2008 Marmaduke Brooker Serial televisi Cloverfield 2008 Hudson Hud Platt Extract 2009 Rory Goods: Live Hard, Sell Hard, TheThe Goods: Live Hard, Sell Hard 2009 Cessna Jim S...

Coma

State of unconsciousness For other uses, see Coma (disambiguation). Not to be confused with Comma or Colma. Comas redirects here. For other uses, see Comas (disambiguation). Medical conditionComaImage of a comatose man unresponsive to stimuliSpecialtyNeurology, psychiatrySymptomsUnconsciousnessComplicationsPersistent vegetative state, deathDurationCan vary from a few days to several years (longest recorded is 42 years) A coma is a deep state of prolonged unconsciousness in which a person cann...

 

Michaela Gerg

Michaela GergMichaela Gerg nel 2016Nazionalità Germania Ovest Germania (dal 1990) Altezza165 cm Peso57 kg Sci alpino SpecialitàDiscesa libera, supergigante, slalom gigante, slalom speciale, combinata SquadraSC Lenggries Termine carriera1996 Palmarès Competizione Ori Argenti Bronzi Mondiali 0 0 1 Mondiali juniores 3 1 0 Europei juniores 0 2 0 Vedi maggiori dettagli  Modifica dati su Wikidata · Manuale Elisabeth Michaela Gerg (Bad Tölz, 10 novembre 1965) è un'ex sciatrice a...

 

Political movement

Movement to obtain a political goal The mid-19th century Scandinavism political movement led to the modern use of the term Scandinavia. A political movement is a collective attempt by a group of people to change government policy or social values.[1] Political movements are usually in opposition to an element of the status quo,[2] and are often associated with a certain ideology.[3] Some theories of political movements are the political opportunity theory, which states...

Gruppo dell'azoto

Campioni degli elementi del gruppo dell'azoto. Gli elementi del gruppo 15 della tavola periodica o elementi del gruppo dell'azoto sono: azoto (N), fosforo (P), arsenico (As), antimonio (Sb) e bismuto (Bi). Anche il moscovio (Mc) appartiene a questo gruppo, ma ne è stato prodotto solo qualche atomo e le sue proprietà fondamentali sono ancora sconosciute.[1] Nella nomenclatura chimica precedente il gruppo 15 era denominato VB o VA. Questi elementi sono anche chiamati pnicogeni, nome p...

 

Hampton Hawes at the Piano

1978 studio album by Hampton HawesHampton Hawes at the PianoStudio album by Hampton HawesReleased1978RecordedAugust 14, 1976StudioContemporary Records Studio, Los Angeles, CAGenreJazzLength38:50LabelContemporary S7637ProducerLester Koenig and John KoenigHampton Hawes chronology Memory Lane Live(1977) Hampton Hawes at the Piano(1978) As Long as There's Music(1978) Hampton Hawes at the Piano is an album by American jazz pianist Hampton Hawes, recorded in 1976 and released on the Contemp...