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Signal transducer and activator of transcription 6, interleukin-4 induced
信号转导及转录激活蛋白6，白介素-4诱导
Signal transducer and activator of transcription 6, interleukin-4 induced; 信号转导及转录激活蛋白6，白介素-4诱导
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	1OJ5
标识
代号	STAT6; D12S1644; IL-4-STAT; STAT6B; STAT6C
扩展标识	遗传学：601512 鼠基因：103034 同源基因：2373 ChEMBL: 5401 GeneCards: STAT6 Gene
基因本体论描述
分子功能	· RNA polymerase II core promoter sequence-specific DNA binding; · sequence-specific DNA binding transcription factor activity; · signal transducer activity; · calcium ion binding; · protein binding; · identical protein binding;
细胞成分	· nuclear chromatin; · nucleus; · nucleolus; · cytoplasm; · cytosol;
生物过程	· negative regulation of transcription from RNA polymerase II promoter; · T-helper 1 cell lineage commitment; · negative regulation of type 2 immune response; · transcription, DNA-dependent; · regulation of transcription from RNA polymerase II promoter; · signal transduction; · cytokine-mediated signaling pathway; · mammary gland epithelial cell proliferation; · regulation of cell proliferation; · positive regulation of transcription from RNA polymerase II promoter; · positive regulation of isotype switching to IgE isotypes; · mammary gland morphogenesis;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体
物种	人类
Entrez	6778
Ensembl	ENSG00000166888
UniProt	P42226
mRNA序列	NM_001178078
蛋白序列	NP_001171549
基因位置	Chr 12:; 57.49 – 57.53 Mb
PubMed查询	[1]
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信号转导及转录激活蛋白6（英語：Signal transducer and activator of transcription 6，STAT6）是一种由人类基因STAT6 编码的转录因子^[1]^[2]。

相互作用

STAT3能与下列蛋白質发生交互作用：

EP300,^[3] CREB-binding protein,^[3]^[4] NFKB1,^[5] Nuclear receptor coactivator 1,^[4]^[6] IRF4^[7]和SND1^[8]。

另见

白细胞介素-4

参考文献

^ Leek JP, Hamlin PJ, Bell SM, Lench NJ. Assignment of the STAT6 gene (STAT6) to human chromosome band 12q13 by in situ hybridization. Cytogenet. Cell Genet. 1997, 79 (3–4): 208–9. PMID 9605853. doi:10.1159/000134723.
^ Hou J, Schindler U, Henzel WJ, Ho TC, Brasseur M, McKnight SL. An interleukin-4-induced transcription factor: IL-4 Stat. Science. September 1994, 265 (5179): 1701–6. PMID 8085155. doi:10.1126/science.8085155.
^ ^3.0 ^3.1 McDonald, C; Reich N C. Cooperation of the transcriptional coactivators CBP and p300 with Stat6. J. Interferon Cytokine Res. (UNITED STATES). July 1999, 19 (7): 711–22. ISSN 1079-9907. PMID 10454341. doi:10.1089/107999099313550.
^ ^4.0 ^4.1 Litterst, C M; Pfitzner E. Transcriptional activation by STAT6 requires the direct interaction with NCoA-1. J. Biol. Chem. (United States). Dec 2001, 276 (49): 45713–21. ISSN 0021-9258. PMID 11574547. doi:10.1074/jbc.M108132200.
^ Shen, C H; Stavnezer J. Interaction of stat6 and NF-kappaB: direct association and synergistic activation of interleukin-4-induced transcription. Mol. Cell. Biol. (UNITED STATES). June 1998, 18 (6): 3395–404. ISSN 0270-7306. PMC 108921 . PMID 9584180.
^ Litterst, Claudia M; Pfitzner Edith. An LXXLL motif in the transactivation domain of STAT6 mediates recruitment of NCoA-1/SRC-1. J. Biol. Chem. (United States). September 2002, 277 (39): 36052–60. ISSN 0021-9258. PMID 12138096. doi:10.1074/jbc.M203556200.
^ Gupta, S; Jiang M; Anthony A; Pernis A B. Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4. J. Exp. Med. (UNITED STATES). Dec 1999, 190 (12): 1837–48. ISSN 0022-1007. PMC 2195723 . PMID 10601358. doi:10.1084/jem.190.12.1837.
^ Yang, Jie; Aittomäki Saara; Pesu Marko; Carter Kara; Saarinen Jussi; Kalkkinen Nisse; Kieff Elliott; Silvennoinen Olli. Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II. EMBO J. (England). September 2002, 21 (18): 4950–8. ISSN 0261-4189. PMC 126276 . PMID 12234934. doi:10.1093/emboj/cdf463.

延伸阅读

Jiang H, Harris MB, Rothman P. IL-4/IL-13 signaling beyond JAK/STAT. J. Allergy Clin. Immunol. 2000, 105 (6 Pt 1): 1063–70. PMID 10856136. doi:10.1067/mai.2000.107604.
Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW. Signaling through the JAK/STAT pathway, recent advances and future challenges. Gene. 2002, 285 (1–2): 1–24. PMID 12039028. doi:10.1016/S0378-1119(02)00398-0.
Hou J, Schindler U, Henzel WJ; et al. An interleukin-4-induced transcription factor: IL-4 Stat. Science. 1994, 265 (5179): 1701–6. PMID 8085155. doi:10.1126/science.8085155.
Takeda K, Tanaka T, Shi W; et al. Essential role of Stat6 in IL-4 signalling. Nature. 1996, 380 (6575): 627–30. PMID 8602263. doi:10.1038/380627a0.
Shimoda K, van Deursen J, Sangster MY; et al. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature. 1996, 380 (6575): 630–3. PMID 8602264. doi:10.1038/380630a0.
Kotanides H, Reich NC. Interleukin-4-induced STAT6 recognizes and activates a target site in the promoter of the interleukin-4 receptor gene. J. Biol. Chem. 1996, 271 (41): 25555–61. PMID 8810328. doi:10.1074/jbc.271.41.25555.
Mikita T, Campbell D, Wu P; et al. Requirements for interleukin-4-induced gene expression and functional characterization of Stat6. Mol. Cell. Biol. 1996, 16 (10): 5811–20. PMC 231582 . PMID 8816495.
Shen CH, Stavnezer J. Interaction of stat6 and NF-kappaB: direct association and synergistic activation of interleukin-4-induced transcription. Mol. Cell. Biol. 1998, 18 (6): 3395–404. PMC 108921 . PMID 9584180.
Leek JP, Hamlin PJ, Bell SM, Lench NJ. Assignment of the STAT6 gene (STAT6) to human chromosome band 12q13 by in situ hybridization. Cytogenet. Cell Genet. 1998, 79 (3–4): 208–9. PMID 9605853. doi:10.1159/000134723.
Mikita T, Kurama M, Schindler U. Synergistic activation of the germline epsilon promoter mediated by Stat6 and C/EBP beta. J. Immunol. 1998, 161 (4): 1822–8. PMID 9712049.
Patel BK, Keck CL, O'Leary RS; et al. Localization of the human stat6 gene to chromosome 12q13.3-q14.1, a region implicated in multiple solid tumors. Genomics. 1998, 52 (2): 192–200. PMID 9782085. doi:10.1006/geno.1998.5436.
Zhu M, John S, Berg M, Leonard WJ. Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling. Cell. 1999, 96 (1): 121–30. PMID 9989503. doi:10.1016/S0092-8674(00)80965-4.
McDonald C, Reich NC. Cooperation of the transcriptional coactivators CBP and p300 with Stat6. J. Interferon Cytokine Res. 1999, 19 (7): 711–22. PMID 10454341. doi:10.1089/107999099313550.
Harris MB, Chang CC, Berton MT; et al. Transcriptional repression of Stat6-dependent interleukin-4-induced genes by BCL-6: specific regulation of iepsilon transcription and immunoglobulin E switching. Mol. Cell. Biol. 2000, 19 (10): 7264–75. PMC 84719 . PMID 10490661.
Gupta S, Jiang M, Pernis AB. IFN-alpha activates Stat6 and leads to the formation of Stat2:Stat6 complexes in B cells. J. Immunol. 1999, 163 (7): 3834–41. PMID 10490982.
Gupta S, Jiang M, Anthony A, Pernis AB. Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4. J. Exp. Med. 2000, 190 (12): 1837–48. PMC 2195723 . PMID 10601358. doi:10.1084/jem.190.12.1837.
Daniel C, Salvekar A, Schindler U. A gain-of-function mutation in STAT6. J. Biol. Chem. 2000, 275 (19): 14255–9. PMID 10747856. doi:10.1074/jbc.C000129200.
Arinobu Y, Sugimoto R, Akaiwa M; et al. Augmentation of signal transducer and activation of transcription (STAT)6 and STAT3 expression in stimulated B and T cells. Biochem. Biophys. Res. Commun. 2000, 277 (2): 317–24. PMID 11032724. doi:10.1006/bbrc.2000.3674.
Masuda A, Matsuguchi T, Yamaki K; et al. Interleukin-15 prevents mouse mast cell apoptosis through STAT6-mediated Bcl-xL expression. J. Biol. Chem. 2001, 276 (28): 26107–13. PMID 11369758. doi:10.1074/jbc.M011475200.

外部链接

醫學主題詞表（MeSH）：STAT6+Transcription+Factor

[pmid9605853-1] Leek JP, Hamlin PJ, Bell SM, Lench NJ. Assignment of the STAT6 gene (STAT6) to human chromosome band 12q13 by in situ hybridization. Cytogenet. Cell Genet. 1997, 79 (3–4): 208–9. PMID 9605853. doi:10.1159/000134723.

[pmid8085155-2] Hou J, Schindler U, Henzel WJ, Ho TC, Brasseur M, McKnight SL. An interleukin-4-induced transcription factor: IL-4 Stat. Science. September 1994, 265 (5179): 1701–6. PMID 8085155. doi:10.1126/science.8085155.

[pmid10454341-3] 3.0 ^3.1 McDonald, C; Reich N C. Cooperation of the transcriptional coactivators CBP and p300 with Stat6. J. Interferon Cytokine Res. (UNITED STATES). July 1999, 19 (7): 711–22. ISSN 1079-9907. PMID 10454341. doi:10.1089/107999099313550.

[pmid11574547-4] 4.0 ^4.1 Litterst, C M; Pfitzner E. Transcriptional activation by STAT6 requires the direct interaction with NCoA-1. J. Biol. Chem. (United States). Dec 2001, 276 (49): 45713–21. ISSN 0021-9258. PMID 11574547. doi:10.1074/jbc.M108132200.

[pmid9584180-5] Shen, C H; Stavnezer J. Interaction of stat6 and NF-kappaB: direct association and synergistic activation of interleukin-4-induced transcription. Mol. Cell. Biol. (UNITED STATES). June 1998, 18 (6): 3395–404. ISSN 0270-7306. PMC 108921 . PMID 9584180.

[pmid12138096-6] Litterst, Claudia M; Pfitzner Edith. An LXXLL motif in the transactivation domain of STAT6 mediates recruitment of NCoA-1/SRC-1. J. Biol. Chem. (United States). September 2002, 277 (39): 36052–60. ISSN 0021-9258. PMID 12138096. doi:10.1074/jbc.M203556200.

[pmid10601358-7] Gupta, S; Jiang M; Anthony A; Pernis A B. Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4. J. Exp. Med. (UNITED STATES). Dec 1999, 190 (12): 1837–48. ISSN 0022-1007. PMC 2195723 . PMID 10601358. doi:10.1084/jem.190.12.1837.

[pmid12234934-8] Yang, Jie; Aittomäki Saara; Pesu Marko; Carter Kara; Saarinen Jussi; Kalkkinen Nisse; Kieff Elliott; Silvennoinen Olli. Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II. EMBO J. (England). September 2002, 21 (18): 4950–8. ISSN 0261-4189. PMC 126276 . PMID 12234934. doi:10.1093/emboj/cdf463.

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