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早期生长应答蛋白3
Early growth response 3
早期生长应答蛋白3; Early growth response 3
标识
代号	EGR3; EGR-3; PILOT
扩展标识	遗传学：602419 鼠基因：1306780 同源基因：37923 GeneCards: EGR3 Gene
基因本体论描述
分子功能	· DNA binding; · sequence-specific DNA binding transcription factor activity; · zinc ion binding;
细胞成分	· nucleus;
生物过程	· positive regulation of endothelial cell proliferation; · cell migration involved in sprouting angiogenesis; · transcription, DNA-dependent; · neuromuscular synaptic transmission; · peripheral nervous system development; · muscle organ development; · circadian rhythm; · endothelial cell chemotaxis; · cellular response to vascular endothelial growth factor stimulus; · negative regulation of apoptotic process; · cellular response to fibroblast growth factor stimulus;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体
物种	人类
Entrez	1960
Ensembl	ENSG00000179388
UniProt	Q06889
mRNA序列	NM_001199880
蛋白序列	NP_001186809
基因位置	Chr 8:; 22.55 – 22.55 Mb
PubMed查询	[1]
	查; 论; 编;

早期生长反应蛋白3（英語：Early growth response protein 3，EGR-3）是一个由人类基因EGR3编码的蛋白质^[1]^[2]^[3]。

该基因编码的蛋白为EGR家族的Cys2His2型锌指结构转录因子。这是一个是由有丝分裂刺激诱导的早期生长反应基因。由该基因编码的蛋白参与了控制生物节律的转录调控。它也可能在肌肉发育中起作用。^[3]

参考文献

^ Patwardhan S, Gashler A, Siegel MG, Chang LC, Joseph LJ, Shows TB, Le Beau MM, Sukhatme VP. EGR3, a novel member of the Egr family of genes encoding immediate-early transcription factors. Oncogene. Aug 1991, 6 (6): 917–28. PMID 1906159.
^ Yang Y, Dong B, Mittelstadt PR, Xiao H, Ashwell JD. HIV Tat binds Egr proteins and enhances Egr-dependent transactivation of the Fas ligand promoter. J Biol Chem. May 2002, 277 (22): 19482–19487. PMID 11909874. doi:10.1074/jbc.M201687200.
^ ^3.0 ^3.1 Entrez Gene: EGR3 early growth response 3. （原始内容存档于2019-10-16）.

延伸阅读

Yamada K; Gerber DJ; Iwayama Y; et al. Genetic analysis of the calcineurin pathway identifies members of the EGR gene family, specifically EGR3, as potential susceptibility candidates in schizophrenia. Proc. Natl. Acad. Sci. U.S.A. 2007, 104 (8): 2815–2820. PMC 1815264 . PMID 17360599. doi:10.1073/pnas.0610765104.
Gerhard DS; Wagner L; Feingold EA; et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004, 14 (10B): 2121–2127. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Yoo YG, Lee MO. Hepatitis B virus X protein induces expression of Fas ligand gene through enhancing transcriptional activity of early growth response factor. J. Biol. Chem. 2004, 279 (35): 36242–36249. PMID 15173177. doi:10.1074/jbc.M401290200.
Inoue A; Omoto Y; Yamaguchi Y; et al. Transcription factor EGR3 is involved in the estrogen-signaling pathway in breast cancer cells. J. Mol. Endocrinol. 2005, 32 (3): 649–661. PMID 15171706. doi:10.1677/jme.0.0320649.
Liu D; Jia H; Holmes DI; et al. Vascular endothelial growth factor-regulated gene expression in endothelial cells: KDR-mediated induction of Egr3 and the related nuclear receptors Nur77, Nurr1, and Nor1. Arterioscler. Thromb. Vasc. Biol. 2004, 23 (11): 2002–2007. PMID 14525795. doi:10.1161/01.ATV.0000098644.03153.6F.
Strausberg RL; Feingold EA; Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–16903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Tourtellotte WG, Milbrandt J. Sensory ataxia and muscle spindle agenesis in mice lacking the transcription factor Egr3. Nat. Genet. 1998, 20 (1): 87–91. PMID 9731539. doi:10.1038/1757.
Morris ME; Viswanathan N; Kuhlman S; et al. A screen for genes induced in the suprachiasmatic nucleus by light. Science. 1998, 279 (5356): 1544–1547. PMID 9488654. doi:10.1126/science.279.5356.1544.
Hillier LD; Lennon G; Becker M; et al. Generation and analysis of 280,000 human expressed sequence tags. Genome Res. 1997, 6 (9): 807–828. PMID 8889549. doi:10.1101/gr.6.9.807.
Mages HW; Stamminger T; Rilke O; et al. Expression of PILOT, a putative transcription factor, requires two signals and is cyclosporin A sensitive in T cells. Int. Immunol. 1993, 5 (1): 63–70. PMID 8443122. doi:10.1093/intimm/5.1.63.

外部链接

醫學主題詞表（MeSH）：EGR3+protein,+human

EGR3引用了美国国家医学图书馆提供的資料，这些資料属于公共领域。

[pmid1906159-1] Patwardhan S, Gashler A, Siegel MG, Chang LC, Joseph LJ, Shows TB, Le Beau MM, Sukhatme VP. EGR3, a novel member of the Egr family of genes encoding immediate-early transcription factors. Oncogene. Aug 1991, 6 (6): 917–28. PMID 1906159.

[pmid11909874-2] Yang Y, Dong B, Mittelstadt PR, Xiao H, Ashwell JD. HIV Tat binds Egr proteins and enhances Egr-dependent transactivation of the Fas ligand promoter. J Biol Chem. May 2002, 277 (22): 19482–19487. PMID 11909874. doi:10.1074/jbc.M201687200.

[entrez-3] 3.0 ^3.1 Entrez Gene: EGR3 early growth response 3. （原始内容存档于2019-10-16）.

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