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朊毒體蛋白
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1E1G、1E1J、1E1P、1E1S、1E1U、1E1W、1FKC、1FO7、1H0L、1HJM、1HJN、1I4M、1OEH、1OEI、1QLX、1QLZ、1QM0、1QM1、1QM2、1QM3、2IV4、2IV5、2IV6、2K1D、2KUN、2LBG、2LEJ、2LFT、2LSB、2LV1、2OL9、2W9E、3HAF、3HAK、3HEQ、3HER、3HES、3HJ5、3HJX、3MD4、3MD5、3NHC、3NHD、3NVF、4DGI、4E1H、4E1I,%%s1E1G、1E1J、1E1P、1E1S、1E1U、1E1W、1FKC、1FO7、1H0L、1HJM、1HJN、1I4M、1OEH、1OEI、1QLX、1QLZ、1QM0、1QM1、1QM2、1QM3、2IV4、2IV5、2IV6、2K1D、2KUN、2LBG、2LEJ、2LFT、2LSB、2LV1、2M8T、2W9E、3HAF、3HAK、3HEQ、3HER、3HES、3HJ5、3HJX、3MD4、3MD5、3NHC、3NVF、4DGI、4E1H、4E1I、4KML、4N9O
識別號
别名	PRNP；, ASCR, AltPrP, CD230, CJD, GSS, KURU, PRIP, PrP, PrP27-30, PrP33-35C, PrPc, p27-30, prion protein
外部ID	OMIM：176640 MGI：97769 HomoloGene：7904 GeneCards：PRNP
相關疾病
	傳染性海綿狀腦病、克雅二氏病、致死性家族失眠症、Gerstmann–Sträussler–Scheinker症候群、Huntington disease-like 1、spongiform encephalopathy with neuropsychiatric features、inherited Creutzfeldt–Jakob disease
基因位置（人类）
染色体	20號染色體
终止	4,701,590 bp
基因位置（小鼠）
染色体	小鼠2号染色体
终止	131,780,349 bp
RNA表达模式
	; ;
	查阅更多表达数据
基因本體
分子功能	• chaperone binding; • transmembrane transporter binding; • microtubule binding; • ATP-dependent protein binding; • 金屬離子結合; • tubulin binding; • 血浆蛋白结合; • 相同蛋白质结合; • copper ion binding; • lamin binding; • amyloid-beta binding; • 蛋白酶結合; • glycosaminoglycan binding; • type 5 metabotropic glutamate receptor binding; • type 8 metabotropic glutamate receptor binding; • signaling receptor activity; • 大分子复合物结合; • cupric ion binding; • cuprous ion binding;
細胞組分	• mitochondrial outer membrane; • 膜; • 線粒體; • integral component of membrane; • 細胞質; • 高尔基体; • 细胞膜; • cell surface; • 内质网; • 脂筏模型; • anchored component of membrane; • 外排體; • 细胞核; • extrinsic component of membrane; • 细胞质基质; • 突触后致密物质; • 包涵体; • 树突; • anchored component of external side of plasma membrane; • 核膜; • 細胞內膜結合細胞器; • postsynapse;
生物學過程	• negative regulation of protein phosphorylation; • negative regulation of interferon-gamma production; • response to cadmium ion; • negative regulation of calcineurin-NFAT signaling cascade; • response to copper ion; • negative regulation of apoptotic process; • response to oxidative stress; • negative regulation of DNA-binding transcription factor activity; • negative regulation of T cell receptor signaling pathway; • regulation of protein localization; • negative regulation of activated T cell proliferation; • 学习和记忆; • cellular copper ion homeostasis; • cellular response to copper ion; • 細胞週期; • 代謝; • negative regulation of interleukin-17 production; • protein homooligomerization; • negative regulation of interleukin-2 production; • regulation of potassium ion transmembrane transport; • 长期记忆; • positive regulation of cell death; • negative regulation of protein processing; • protein destabilization; • activation of protein kinase activity; • calcium-mediated signaling using intracellular calcium source; • negative regulation of catalytic activity; • positive regulation of neuron apoptotic process; • regulation of peptidyl-tyrosine phosphorylation; • positive regulation of peptidyl-tyrosine phosphorylation; • positive regulation of protein tyrosine kinase activity; • positive regulation of protein targeting to membrane; • dendritic spine maintenance; • negative regulation of long-term synaptic potentiation; • regulation of glutamate receptor signaling pathway; • positive regulation of neuron death; • negative regulation of amyloid-beta formation; • regulation of intracellular calcium activated chloride channel activity; • negative regulation of dendritic spine maintenance; • negative regulation of amyloid precursor protein catabolic process; • positive regulation of protein localization to plasma membrane; • response to amyloid-beta; • cellular response to amyloid-beta; • regulation of calcium ion import across plasma membrane; • neuron projection maintenance;
	Sources:Amigo / QuickGO
直系同源
	5621
	19122
	ENSG00000171867
	ENSMUSG00000079037
	P04156
	P04925
NM_183079; NM_000311; NM_001080121; NM_001080122; NM_001080123;
	NM_001271561
	NM_001278256; NM_011170
NP_000302; NP_001073590; NP_001073591; NP_001073592; NP_001258490;
	NP_898902; NP_000302.1; NP_001073590.1; NP_001073591.1; NP_001073592.1; NP_898902.1
	NP_001265185; NP_035300
	維基數據
檢視/編輯人類	檢視/編輯小鼠

PRNP（普里昂蛋白）為人類主要普里昂蛋白PrP的基因編碼，也稱之為CD230（分化簇230）^[6]^[7]^[8]^[9]。該蛋白的主要表达于神經系統，但也會表达在人體其他組織^[10]^[11]^[12]。

參考文獻

^ 與朊毒體蛋白相關的疾病；在維基數據上查看/編輯參考.
^ ^2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000171867 - Ensembl, May 2017
^ ^3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000079037 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kretzschmar, Hans A.; Stowring, Linda E.; Westaway, David; Stubblebine, William H.; Prusiner, Stanley B.; Dearmond, Stephen J. Molecular Cloning of a Human Prion Protein cDNA. DNA. 1986-08, 5 (4) [2022-11-11]. ISSN 0198-0238. PMID 3755672. doi:10.1089/dna.1986.5.315. （原始内容存档于2020-02-23）（英语）.
^ Sparkes, R S; Simon, M; Cohn, V H; Fournier, R E; Lem, J; Klisak, I; Heinzmann, C; Blatt, C; Lucero, M; Mohandas, T. Assignment of the human and mouse prion protein genes to homologous chromosomes.. Proceedings of the National Academy of Sciences. 1986-10, 83 (19). Bibcode:1986PNAS...83.7358S. ISSN 0027-8424. PMC 386716 . PMID 3094007. doi:10.1073/pnas.83.19.7358 （英语）.
^ Liao, Yu-Cheng; Lebo, Roger V.; Clawson, Gary A.; Smuckler, Edward A. Human Prion Protein cDNA: Molecular Cloning, Chromosomal Mapping, and Biological Implications. Science. 1986-07-18, 233 (4761) [2022-11-11]. Bibcode:1986Sci...233..364L. ISSN 0036-8075. PMID 3014653. doi:10.1126/science.3014653. （原始内容存档于2022-11-12）（英语）.
^ Robakis, N. K.; Devine-Gage, E. A.; Jenkins, E. C.; Kascsak, R. J.; Brown, W. T.; Krawczun, M. S.; Silverman, W. P. Localization of a human gene homologous to the PrP gene on the p arm of chromosome 20 and detection of PrP-related antigens in normal human brain. Biochemical and Biophysical Research Communications. 1986-10-30, 140 (2) [2022-11-11]. ISSN 0006-291X. PMID 2877664. doi:10.1016/0006-291x(86)90796-5. （原始内容存档于2022-11-11）.
^ Prusiner, Stanley B. Neurodegenerative Diseases and Prions. New England Journal of Medicine. 2001-05-17, 344 (20). ISSN 0028-4793. PMID 11357156. doi:10.1056/NEJM200105173442006 （英语）.
^ Weissmann, Charles. The state of the prion. Nature Reviews Microbiology. 2004-11, 2 (11) [2022-11-11]. ISSN 1740-1526. PMID 15494743. doi:10.1038/nrmicro1025. （原始内容存档于2022-11-11）（英语）.
^ Zomosa-Signoret, Viviana; Arnaud, Jacques-Damien; Fontes, Pascaline; Alvarez-Martinez, Maria-Terresa; Liautard, Jean-Pierre. Physiological role of the cellular prion protein. Veterinary Research. 2008-07, 39 (4). ISSN 0928-4249. PMID 18073096. doi:10.1051/vetres:2007048.

[1] 與朊毒體蛋白相關的疾病；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-2] 2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000171867 - Ensembl, May 2017

[refGRCm38Ensembl-3] 3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000079037 - Ensembl, May 2017

[4] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3755672-6] Kretzschmar, Hans A.; Stowring, Linda E.; Westaway, David; Stubblebine, William H.; Prusiner, Stanley B.; Dearmond, Stephen J. Molecular Cloning of a Human Prion Protein cDNA. DNA. 1986-08, 5 (4) [2022-11-11]. ISSN 0198-0238. PMID 3755672. doi:10.1089/dna.1986.5.315. （原始内容存档于2020-02-23）（英语）.

[pmid3094007-7] Sparkes, R S; Simon, M; Cohn, V H; Fournier, R E; Lem, J; Klisak, I; Heinzmann, C; Blatt, C; Lucero, M; Mohandas, T. Assignment of the human and mouse prion protein genes to homologous chromosomes.. Proceedings of the National Academy of Sciences. 1986-10, 83 (19). Bibcode:1986PNAS...83.7358S. ISSN 0027-8424. PMC 386716 . PMID 3094007. doi:10.1073/pnas.83.19.7358 （英语）.

[pmid3014653-8] Liao, Yu-Cheng; Lebo, Roger V.; Clawson, Gary A.; Smuckler, Edward A. Human Prion Protein cDNA: Molecular Cloning, Chromosomal Mapping, and Biological Implications. Science. 1986-07-18, 233 (4761) [2022-11-11]. Bibcode:1986Sci...233..364L. ISSN 0036-8075. PMID 3014653. doi:10.1126/science.3014653. （原始内容存档于2022-11-12）（英语）.

[pmid2877664-9] Robakis, N. K.; Devine-Gage, E. A.; Jenkins, E. C.; Kascsak, R. J.; Brown, W. T.; Krawczun, M. S.; Silverman, W. P. Localization of a human gene homologous to the PrP gene on the p arm of chromosome 20 and detection of PrP-related antigens in normal human brain. Biochemical and Biophysical Research Communications. 1986-10-30, 140 (2) [2022-11-11]. ISSN 0006-291X. PMID 2877664. doi:10.1016/0006-291x(86)90796-5. （原始内容存档于2022-11-11）.

[pmid11357156-10] Prusiner, Stanley B. Neurodegenerative Diseases and Prions. New England Journal of Medicine. 2001-05-17, 344 (20). ISSN 0028-4793. PMID 11357156. doi:10.1056/NEJM200105173442006 （英语）.

[pmid15494743-11] Weissmann, Charles. The state of the prion. Nature Reviews Microbiology. 2004-11, 2 (11) [2022-11-11]. ISSN 1740-1526. PMID 15494743. doi:10.1038/nrmicro1025. （原始内容存档于2022-11-11）（英语）.

[review2-12] Zomosa-Signoret, Viviana; Arnaud, Jacques-Damien; Fontes, Pascaline; Alvarez-Martinez, Maria-Terresa; Liautard, Jean-Pierre. Physiological role of the cellular prion protein. Veterinary Research. 2008-07, 39 (4). ISSN 0928-4249. PMID 18073096. doi:10.1051/vetres:2007048.

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