Рецептор ламіну B

LBR
Наявні структури
PDBПошук ортологів: C9JXK0 PDBe C9JXK0 RCSB
Ідентифікатори
Символи LBR, DHCR14B, LMN2R, PHA, TDRD18, lamin B receptor, PHASK, C14SR
Зовнішні ІД OMIM: 600024 MGI: 2138281 HomoloGene: 2455 GeneCards: LBR
Пов'язані генетичні захворювання
Pelger-Huet anomaly, hydrops-ectopic calcification-moth-eaten skeletal dysplasia, regressive spondylometaphyseal dysplasia[1]
Шаблон експресії
Більше даних
Ортологи
Види Людина Миша
Entrez
Ensembl
UniProt
RefSeq (мРНК)
NM_002296
NM_194442
NM_133815
RefSeq (білок)
NP_002287
NP_919424
NP_598576
Локус (UCSC) Хр. 1: 225.4 – 225.43 Mb Хр. 1: 181.64 – 181.67 Mb
PubMed search [2] [3]
Вікідані
Див./Ред. для людейДив./Ред. для мишей

LBR (англ. Lamin B receptor) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 1-ї хромосоми. [4] Довжина поліпептидного ланцюга білка становить 615 амінокислот, а молекулярна маса — 70 703[5].

Послідовність амінокислот
1020304050
MPSRKFADGEVVRGRWPGSSLYYEVEILSHDSTSQLYTVKYKDGTELELK
ENDIKPLTSFRQRKGGSTSSSPSRRRGSRSRSRSRSPGRPPKSARRSASA
SHQADIKEARREVEVKLTPLILKPFGNSISRYNGEPEHIERNDAPHKNTQ
EKFSLSQESSYIATQYSLRPRREEVKLKEIDSKEEKYVAKELAVRTFEVT
PIRAKDLEFGGVPGVFLIMFGLPVFLFLLLLMCKQKDPSLLNFPPPLPAL
YELWETRVFGVYLLWFLIQVLFYLLPIGKVVEGTPLIDGRRLKYRLNGFY
AFILTSAVIGTSLFQGVEFHYVYSHFLQFALAATVFCVVLSVYLYMRSLK
APRNDLSPASSGNAVYDFFIGRELNPRIGTFDLKYFCELRPGLIGWVVIN
LVMLLAEMKIQDRAVPSLAMILVNSFQLLYVVDALWNEEALLTTMDIIHD
GFGFMLAFGDLVWVPFIYSFQAFYLVSHPNEVSWPMASLIIVLKLCGYVI
FRGANSQKNAFRKNPSDPKLAHLKTIHTSTGKNLLVSGWWGFVRHPNYLG
DLIMALAWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKYGVAWE
KYCQRVPYRIFPYIY

Кодований геном білок за функцією належить до рецепторів. Білок має сайт для зв'язування з ДНК. Локалізований у ядрі, мембрані.

Література

  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004.  PMID 15489334 DOI:10.1101/gr.2596504
  • Ye Q., Callebaut I., Pezhman A., Courvalin J.-C., Worman H.J. (1997). Domain-specific interactions of human HP1-type chromodomain proteins and inner nuclear membrane protein LBR. J. Biol. Chem. 272: 14983—14989.  PMID 9169472 DOI:10.1074/jbc.272.23.14983
  • Papoutsopoulou S., Nikolakaki E., Giannakouros T. (1999). SRPK1 and LBR protein kinases show identical substrate specificities. Biochem. Biophys. Res. Commun. 255: 602—607.  PMID 10049757 DOI:10.1006/bbrc.1999.0249
  • Duband-Goulet I., Courvalin J.-C. (2000). Inner nuclear membrane protein LBR preferentially interacts with DNA secondary structures and nucleosomal linker. Biochemistry. 39: 6483—6488.  PMID 10828963 DOI:10.1021/bi992908b
  • Lechner M.S., Schultz D.C., Negorev D., Maul G.G., Rauscher F.J. III (2005). The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain. Biochem. Biophys. Res. Commun. 331: 929—937.  PMID 15882967 DOI:10.1016/j.bbrc.2005.04.016
  • Tseng L.C., Chen R.H. (2011). Temporal control of nuclear envelope assembly by phosphorylation of lamin B receptor. Mol. Biol. Cell. 22: 3306—3317.  PMID 21795390 DOI:10.1091/mbc.E11-03-0199

Примітки

  1. Захворювання, генетично пов'язані з LBR переглянути/редагувати посилання на ВікіДаних. 
  2. Human PubMed Reference:. 
  3. Mouse PubMed Reference:. 
  4. HUGO Gene Nomenclature Commitee, HGNC:6518 (англ.) . Процитовано 25 серпня 2017. {{cite web}}: Обслуговування CS1: Сторінки з параметром url-status, але без параметра archive-url (посилання)
  5. UniProt, Q14739 (англ.) . Процитовано 25 серпня 2017. 

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