CHRDL2

CHRDL2
Ідентифікатори
Символи CHRDL2, BNF1, CHL2, FKSG37, chordin-like 2, chordin like 2
Зовнішні ІД OMIM: 613127 MGI: 1916371 HomoloGene: 128795 GeneCards: CHRDL2
Ортологи
Види Людина Миша
Entrez
Ensembl
UniProt
RefSeq (мРНК)
NM_001291320
NM_133709
RefSeq (білок)
NP_001278249
NP_598470
Локус (UCSC) Хр. 11: 74.7 – 74.73 Mb Хр. 7: 99.66 – 99.68 Mb
PubMed search [1] [2]
Вікідані
Див./Ред. для людейДив./Ред. для мишей

CHRDL2 (англ. Chordin like 2) – білок, який кодується однойменним геном, розташованим у людей на 11-й хромосомі.[3] Довжина поліпептидного ланцюга білка становить 429 амінокислот, а молекулярна маса — 47 495[4].

Послідовність амінокислот
1020304050
MVPEVRVLSSLLGLALLWFPLDSHARARPDMFCLFHGKRYSPGESWHPYL
EPQGLMYCLRCTCSEGAHVSCYRLHCPPVHCPQPVTEPQQCCPKCVEPHT
PSGLRAPPKSCQHNGTMYQHGEIFSAHELFPSRLPNQCVLCSCTEGQIYC
GLTTCPEPGCPAPLPLPDSCCQACKDEASEQSDEEDSVQSLHGVRHPQDP
CSSDAGRKRGPGTPAPTGLSAPLSFIPRHFRPKGAGSTTVKIVLKEKHKK
ACVHGGKTYSHGEVWHPAFRAFGPLPCILCTCEDGRQDCQRVTCPTEYPC
RHPEKVAGKCCKICPEDKADPGHSEISSTRCPKAPGRVLVHTSVSPSPDN
LRRFALEHEASDLVEIYLWKLVKGIFHLTQIKKVRKQDFQKEAQHFRLLA
GPHEGHWNVFLAQTLELKVTASPDKVTKT

Кодований геном білок за функціями належить до білків розвитку, фосфопротеїнів. Задіяний у таких біологічних процесах, як остеогенез, диференціація клітин, альтернативний сплайсинг. Локалізований у цитоплазмі. Також секретований назовні.

Література

  • Wu I., Moses M.A. (2003). BNF-1, a novel gene encoding a putative extracellular matrix protein, is overexpressed in tumor tissues. Gene. 311: 105—110. PMID 12853144 DOI:10.1016/S0378-1119(03)00563-8
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004. PMID 15489334 DOI:10.1101/gr.2596504
  • Zhang Z., Henzel W.J. (2004). Signal peptide prediction based on analysis of experimentally verified cleavage sites. Protein Sci. 13: 2819—2824. PMID 15340161 DOI:10.1110/ps.04682504
  • Picariello G., Ferranti P., Mamone G., Roepstorff P., Addeo F. (2008). Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry. Proteomics. 8: 3833—3847. PMID 18780401 DOI:10.1002/pmic.200701057

Примітки

  1. Human PubMed Reference:.
  2. Mouse PubMed Reference:.
  3. HUGO Gene Nomenclature Commitee, HGNC:24168 (англ.) . Архів оригіналу за 3 червня 2016. Процитовано 19 вересня 2017.
  4. UniProt, Q6WN34 (англ.) . Архів оригіналу за 3 січня 2018. Процитовано 19 вересня 2017.

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