CCT7

CCT7
Ідентифікатори
Символи CCT7, CCTETA, CCTH, NIP7-1, TCP1ETA, chaperonin containing TCP1 subunit 7
Зовнішні ІД OMIM: 605140 MGI: 107184 HomoloGene: 4694 GeneCards: CCT7
Шаблон експресії
Більше даних
Ортологи
Види Людина Миша
Entrez
Ensembl
UniProt
RefSeq (мРНК)
NM_001009570
NM_001166284
NM_001166285
NM_006429
NM_007638
RefSeq (білок)
NP_001009570
NP_001159756
NP_001159757
NP_006420
NP_031664
Локус (UCSC) Хр. 2: 73.23 – 73.25 Mb Хр. 6: 85.43 – 85.45 Mb
PubMed search [1] [2]
Вікідані
Див./Ред. для людейДив./Ред. для мишей

CCT7 (англ. Chaperonin containing TCP1 subunit 7) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 2-ї хромосоми. [3] Довжина поліпептидного ланцюга білка становить 543 амінокислот, а молекулярна маса — 59 367[4].

Послідовність амінокислот
1020304050
MMPTPVILLKEGTDSSQGIPQLVSNISACQVIAEAVRTTLGPRGMDKLIV
DGRGKATISNDGATILKLLDVVHPAAKTLVDIAKSQDAEVGDGTTSVTLL
AAEFLKQVKPYVEEGLHPQIIIRAFRTATQLAVNKIKEIAVTVKKADKVE
QRKLLEKCAMTALSSKLISQQKAFFAKMVVDAVMMLDDLLQLKMIGIKKV
QGGALEDSQLVAGVAFKKTFSYAGFEMQPKKYHNPKIALLNVELELKAEK
DNAEIRVHTVEDYQAIVDAEWNILYDKLEKIHHSGAKVVLSKLPIGDVAT
QYFADRDMFCAGRVPEEDLKRTMMACGGSIQTSVNALSADVLGRCQVFEE
TQIGGERYNFFTGCPKAKTCTFILRGGAEQFMEETERSLHDAIMIVRRAI
KNDSVVAGGGAIEMELSKYLRDYSRTIPGKQQLLIGAYAKALEIIPRQLC
DNAGFDATNILNKLRARHAQGGTWYGVDINNEDIADNFEAFVWEPAMVRI
NALTAASEAACLIVSVDETIKNPRSTVDAPTAAGRGRGRGRPH

Кодований геном білок за функцією належить до шаперонів. Білок має сайт для зв'язування з АТФ, нуклеотидами. Локалізований у цитоплазмі.

Література

  • Won K.-A., Schumacher R.J., Farr G.W., Horwich A.L., Reed S.I. (1998). Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT. Mol. Cell. Biol. 18: 7584—7589. PMID 9819444 DOI:10.1128/MCB.18.12.7584
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004. PMID 15489334 DOI:10.1101/gr.2596504

Примітки

  1. Human PubMed Reference:.
  2. Mouse PubMed Reference:.
  3. HUGO Gene Nomenclature Commitee, HGNC:1622 (англ.) . Процитовано 6 лютого 2017.{{cite web}}: Обслуговування CS1: Сторінки з параметром url-status, але без параметра archive-url (посилання)
  4. UniProt, Q99832 (англ.) . Архів оригіналу за 16 вересня 2016. Процитовано 6 лютого 2017.

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