Соматотропний гормон

Гормон росту 1
Структура гормону росту 1
Ідентифікатори
СимволGH1
Entrez2688
HUGO4261
OMIM139250
RefSeqNM_022562
UniProtP01241
Інша інформація
ЛокусХр. 17 q22-q24
Гормон росту 2
Структура протеїну GH2
Ідентифікатори
СимволGH2
Інші символиGROWTH HORMONE 2
Entrez2689
HUGO4262
OMIM139240
RefSeqNM_002059
UniProtP01242
Інша інформація
ЛокусХр. 17 q22-q24

Соматотропін (соматотропний гормон, СТГ, гормон росту) — гормон, що виробляється аденогіпофізом (передньою долею гіпофізу). СТГ бере участь у регуляції росту, що зумовлено його здатністю посилювати синтез білка в організмі.[1]

Генетика

Родина соматотропних гормонів складається з гормону росту 1 (більш активний гормон, що синтезується в гіпофізі) та гормону росту 2, що експресується переважно в плаценті.[2]

Фізіологія

Регулюється соматоліберинами та соматостатинами гіпоталамуса. Ефектами соматотропіну є посилення утилізації глюкози в тканинах та стимуляція глюконеогенезу (синтезу глюкози з жирів та білків). СТГ має виражений вплив на ріст хрящової тканини.[3]

Патологія

Підвищена концентрація гормону росту внаслідок його посиленого синтезу може призводити до гігантизму і акромегалії, а нестача до карликовості.

Див. також

Примітки

  1. ↑ О.Д. Луцик, А.Й. Іванова, К.С. Кабак, Ю.Б. Чайковський (2003). Гістологія людини. с. 593.
  2. ↑ Melmed, S; Polonsky, KS; Larsen, PR; Kronenberg, HM (2011). Williams Textbook of Endocrinology (вид. 11th). Saunders. с. 478–479. ISBN 978-1416029113.
  3. ↑ Шевчук, В. Г., В. М. Мороз, С. М. Бєлан, М. Р. Гжегоцький, М. В. Йолтухівський (2015). Фізіологія (вид. 2, Підручник для ВМНЗ IV р.). Вінниця: Нова Книга. ISBN 9789663825328. {{cite book}}: Cite має пустий невідомий параметр: |переклад= (довідка)

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