Mepiprazol

Mepiprazol, İspanya'da pazarlanan ve ek antidepresan özelliklere sahip[1] fenilpiperazin grubunun anksiyolitik bir ilacıdır.[2][3][4][5][6] 5-HT2A ve α1-adrenerjik reseptör antagonisti olarak görev yapar[7][8][9] ve geri alımını inhibe eder ve serotonin, dopamin ve norepinefrin salınımını değişen oranlarda indükler[1][9] ve bir serotonin antagonisti ve geri alım inhibitörü (SARI) olarak tanımlanmıştır.[10] İrritabl bağırsak sendromu (IBS) olan hastalarda mepiprazolün kontrollü klinik denemeleri yapılmıştır ve ilacın bazı hastalarda IBS semptomlarını hafifletmede bazı yararları olduğu görülmüştür.[11] Trazodon, nefazodon ve etoperidon gibi diğer fenilpiperazinlere benzer şekilde, mepiprazol aktif metabolit olarak mCPP üretir.[12]

Kaynakça

  1. ^ a b "Mepiprazole, a new psychotropic drug: effects on uptake and retention of monoamines in rat brain synaptosomes". Psychopharmacology. 48 (3): 295-301. August 1976. doi:10.1007/BF00496865. PMID 9660. 
  2. ^ J. Elks (14 Kasım 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. ss. 768-. ISBN 978-1-4757-2085-3. 
  3. ^ Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. ISBN 3-88763-075-0. 
  4. ^ Pöldinger W (1975). "Clinical trial of 3-methyl-5-(beta-N'-(N-m-chlorophenylpiperazino)ethyl)-pyrazole dihydrochloride (Mepiprazol) in the therapy of psychovegetative disorders". International Pharmacopsychiatry. 10 (1): 1-8. doi:10.1159/000468162. PMID 1095510. 
  5. ^ "[A controlled double-blind crossover study of the efficacy of mepiprazol (EMD 16.923) and of diazepam in the treatment of neurotic disorders]". Acta Psychiatrica Belgica (Fransızca). 75 (3): 320-33. May 1975. PMID 769484. 
  6. ^ "[Psychopharmological research with EMD 16-923 in patients with different degrees of anxiety]". Neurología, Neurocirugía, Psiquiatría (İspanyolca). 17 (1): 29-33. 1976. PMID 1052713. 
  7. ^ "Evidence that blood pressure reduction by serotonin antagonists is related to alpha receptor blockade in spontaneously hypertensive rats". Hypertension. 5 (5): 676-81. 1983. doi:10.1161/01.hyp.5.5.676. PMID 6311738. 
  8. ^ "Central action of mepiprazole". Polish Journal of Pharmacology and Pharmacy. 32 (4): 475-84. 1980. PMID 7255266. 
  9. ^ a b "The effect of mepiprazole on central monoamine neurons. Evidence for increased 5-hydroxytryptamine and dopamine receptor activity". European Journal of Pharmacology. 35 (1): 93-108. January 1976. doi:10.1016/0014-2999(76)90304-6. PMID 943291. 
  10. ^ Fagiolini (2012). "Rediscovering Trazodone for the Treatment of Major Depressive Disorder". CNS Drugs. 26 (12): 1033-1049. doi:10.1007/s40263-012-0010-5. ISSN 1172-7047. PMC 3693429 $2. PMID 23192413. 
  11. ^ "Controlled clinical trial of mepiprazole in irritable bowel syndrome". The British Medical Journal. 4 (5935): 16-8. October 1974. doi:10.1136/bmj.4.5935.16. PMC 1612118 $2. PMID 4609545. 
  12. ^ "1-m-Chlorophenylpiperazine is an active metabolite common to the psychotropic drugs trazodone, etoperidone and mepiprazole". The Journal of Pharmacy and Pharmacology. 34 (10): 674-5. October 1982. doi:10.1111/j.2042-7158.1982.tb04701.x. PMID 6128394.