Ang kromosomang 3 o kulaylawas[ 1] (Ingles: Chromosome 3 ) ang isa sa 23 mga pares ng kromosoma sa mga tao . Ang mga tao ay normal na mayroong dalawang kopya ng kromosomang ito. Ang kromosomang 3 ay sumasaklaw sa halos 200 milyong mga base na pares na pantayong materyal ng DNA at kumakatawan sa mga 6.5 porsiyento ng kabuuang DNA sa mga selula .
Ang pagtukoy ng mga gene sa bawat kromosoma ay isang aktibong henetikong pagsasaliksik . Dahil sa ang mga mananaliksik ay gumagamit ng iba't ibang mga paraan sa paghula ng bilang ng mga gene sa bawat kromosoma, ang tinantiyang bilang ng mga gene ay iba iba. Ang kromosomang 3 ay malamang na naglalaman sa pagitan ng 1,100 at 1,500 mga gene.
Mga gene
Ang mga sumusunod ang ilan sa mga gene na matatagpuan sa kromosomang 3:
brasong-p
ALAS1 : aminolevulinate, delta-, synthase 1BTD : biotinidaseCCR5 : chemokine (C-C motif) receptor 5CNTN4 : Contactin 4COL7A1 : Collagen, type VII, alpha 1 (epidermolysis bullosa, dystrophic, dominant and recessive)C3orf14-Chromosome 3 open reading frame 14 : predicted DNA binding protein .MITF : microphthalmia-associated transcription factorMLH1 : mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)OXTR : oxytocin receptorPTHR1 : parathyroid hormone receptor 1SCN5A : sodium channel , voltage-gated, type V, alpha (long QT syndrome 3)SLC25A20 : solute carrier family 25 (carnitine/acylcarnitine translocase), member 20TMIE : transmembrane inner earVHL : von Hippel-Lindau tumor suppressor
brasong-q
ADIPOQ : adiponectinCPOX : coproporphyrinogen oxidase (coproporphyria, harderoporphyria)HGD : homogentisate 1,2-dioxygenase (homogentisate oxidase)IFT122 : intraflagellar transport gene 122MCCC1 : methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)PCCB : propionyl Coenzyme A carboxylase, beta polypeptidePDCD10 : programmed cell death 10PIK3CA : phosphoinositide-3-kinase, catalytic, alpha polypeptideRAB7 : RAB7, member RAS oncogene familyRHO : rhodopsin visual pigmentSOX2 : transcription factorUSH3A : Usher syndrome 3AZNF9 : zinc finger protein 9 (a cellular retroviral nucleic acid binding protein)
Mga sakit at diperensiya
Ang mga sumusunod na sakit ang ilan sa mga nauugnay sa mga gene sa kromosomang 3:
3-methylcrotonyl-CoA carboxylase deficiency 3q29 microdeletion syndrome Alkaptonuria Arrhythmogenic right ventricular dysplasia Atransferrinemia Autism Biotinidase deficiency Blepharophimosis, epicanthus inversus and ptosis type 1 Breast/colon/lung/pancreatic cancer Brugada syndrome Castillo fever Carnitine-acylcarnitine translocase deficiency Cataracts Cerebral cavernous malformation Charcot-Marie-Tooth disease, type 2 Charcot-Marie-Tooth disease Chromosome 3q duplication syndrome
Coproporphyria Deafness Diabetes Dopamine receptor Dystrophic epidermolysis bullosa Endplate acetlycholinesterase deficiency Essential tremors Glaucoma, primary open angle Glycogen storage disease Hailey-Hailey disease Harderoporphyrinuria Heart block, progressive/nonprogressive Hereditary coproporphyria Hereditary nonpolyposis colorectal cancer HIV infection, susceptibility/resistance toHypobetalipoproteinemia, familial Hypothermia Leukoencephalopathy with vanishing white matter Long QT syndrome Lymphomas Malignant hyperthermia susceptibility Metaphyseal chondrodysplasia, Murk Jansen type Moebius syndrome Moyamoya disease Mucopolysaccharidosis Muir-Torre family cancer syndrome Myotonic dystrophy, type 2 Myotonic dystrophy Neuropathy, hereditary motor and sensory, Okinawa type Night blindness Nonsyndromic deafness, autosomal recessive Nonsyndromic deafness Ovarian cancer Porphyria Propionic acidemia Protein S deficiency Pseudo-Zellweger syndrome Retinitis pigmentosa Romano-Ward syndrome Sensenbrenner syndrome Septo-optic dysplasia Short stature Spinocerebellar ataxia Sucrose intolerance T-cell leukemia translocation altered gene Usher syndrome type III Usher syndrome (Finland) Usher syndrome von Hippel-Lindau syndrome Waardenburg syndrome Xeroderma pigmentosum, complementation group c
Mga sanggunian
↑ Maugnaying Talasalitaang Pang-agham Ingles-Pilipino, 1969.
