Stratum corneum himotriptinski enzim

Stratum corneum himotriptinski enzim
Identifikatori
EC broj3.4.21.117
CAS broj155215-90-0
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum

Stratum corneum himotriptinski enzim (EC 3.4.21.117, kalikrein 7, SCCE, KLK7, PRSS6, hK7) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

Razlaganje proteina sa aromatičnim bočnim lacima u P1 poziciji

Ova enzim ima široku supstratnu specifičnost, te može da degradira toplotom-denaturisani goveđi kazein i alfa-lanace prirodnog ljudskog fibrinogena.

Reference

  1. ^ Skytt, A., Strömqvist, M. and Egelrud, T. (1995). „Primary substrate specificity of recombinant human stratum corneum chymotryptic enzyme”. Biochem. Biophys. Res. Commun. 211: 586—589. PMID 7794273. 
  2. ^ Egelrud, T. (1993). „Purification and preliminary characterization of stratum corneum chymotryptic enzyme: a proteinase that may be involved in desquamation”. J. Invest. Dermatol. 101: 200—204. PMID 8393902. 
  3. ^ Hansson, L., Strömqvist, M., Bäckman, A., Wallbrandt, P., Carlstein, A. and Egelrud, T. (1994). „Cloning, expression, and characterization of stratum corneum chymotryptic enzyme. A skin-specific human serine proteinase”. J. Biol. Chem. 269: 19420—19426. PMID 8034709. 
  4. ^ Yousef, G.M., Scorilas, A., Magklara, A., Soosaipillai, A. and Diamandis, E.P. (2000). „The KLK7 (PRSS6) gene, encoding for the stratum corneum chymotryptic enzyme is a new member of the human kallikrein gene family - genomic characterization, mapping, tissue expression and hormonal regulation”. Gene. 254: 119—128. PMID 10974542. 
  5. ^ Vasilopoulos, Y., Cork, M.J., Murphy, R., Williams, H.C., Robinson, D.A., Duff, G.W., Ward, S.J. and Tazi-Ahnini, R. (2004). „Genetic association between an AACC insertion in the 3'UTR of the stratum corneum chymotryptic enzyme gene and atopic dermatitis”. J. Invest. Dermatol. 123: 62—66. PMID 15191543. 

Literatura

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