Proproteinska konvertaza 1

Proproteinska konvertaza 1
Identifikatori
EC broj3.4.21.93
CAS broj99676-46-7
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum

Proproteinska konvertaza 1 (EC 3.4.21.93, prohormonska konvertaza 3, neuroendokrina konvertaza 1, PC1) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

Izdvajanje proteinskih hormona, neuropeptida i renina iz njihovih prekurzora, generalno putem hidrolize -Lys-Arg- veza

Oaj enzim je zavistan od Ca2+, i maksimalno je aktivan na pH 5.5.

Reference

  1. ^ Seidah, N.G., Gaspar, L., Mion, P., Marcinkiewicz, M., Mbikay, M. and Chrétien, M. (1990). „cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases”. DNA Cell Biol. 9: 415—424. PMID 2169760. 
  2. ^ Smeekens, S.P., Avruch, A.S., LaMendola, J., Chan, S.J. and Steiner, D.F. (1991). „Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans”. Proc. Natl. Acad. Sci. USA. 88: 340—344. PMID 1988934. 
  3. ^ Steiner, D.F., Smeekens, S.P., Ohagi, S. and Chan, S.J. (1992). „The new enzymology of precursor processing endoproteases”. J. Biol. Chem. 267: 23435—23438. PMID 1429684. 
  4. ^ Seidah, N.G. and Chrétien, M. (1994). „Pro-protein convertases of the subtilisin/kexin family”. Methods Enzymol. 244: 175—188. PMID 7845206. 
  5. ^ Jean, F., Basak, A., Dimaio, J., Seidah, N.G. and Lazure, C. (1995). „An internally quenched fluorogenic substrate of prohormone convertase 1 and furin leads to a potent prohormone convertase inhibitor”. Biochem. J. 307: 689—695. PMID 7741698. 

Literatura

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