Protein geranilgeraniltransferaza tip II

Protein geranilgeraniltransferaza tip II
Identifikatori
EC broj2.5.1.60
CAS broj135371-29-8
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum

Protein geranilgeraniltransferaza tip II (EC 2.5.1.60, GGTaseII, Rab geranilgeraniltransferaza, RabGGTaze, geranilgeranil-difosfat,geranilgeranil-difosfat:protein-cistein geraniltransferaza) je enzim sa sistematskim imenom geranilgeranil-difosfat:protein-cistein geraniltransferaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

geranilgeranil difosfat + protein-cistein S-geranilgeranil-protein + difosfat

Ovaj enzim zajedno sa proteinskom farneziltransferazom (EC 2.5.1.58) i proteinskom geranilgeraniltransferazom tip I (EC 2.5.1.59) sačinjava proteinsku preniltransferaznu familiju enzima.

Reference

  1. ^ Casey, P.J. & Seabra, M.C. (1996). „Protein prenyltransferases”. J. Biol. Chem. 271: 5289—5292. PMID 8621375. 
  2. ^ Wilson, A.L., Erdman, R.A., Castellano, F. and Maltese, W.A. (1998). „Prenylation of Rab8 GTPase by type I and type II geranylgeranyl transferases”. Biochem. J. 333: 497—504. PMID 9677305. 
  3. ^ Zhang, H., Seabra, M.C. and Deisenhofer, J. (2000). „Crystal structure of Rab geranylgeranyltransferase at 2.0 Å resolution”. Structure. 8: 241—251. PMID 10745007. 
  4. ^ Thomä, N.H., Niculae, A., Goody, R.S. and Alexandrov, K. (2001). „Double prenylation by RabGGTase can proceed without dissociation of the mono-prenylated intermediate”. J. Biol. Chem. 276: 48631—48636. PMID 11591706. 
  5. ^ Rak, A., Niculae, A., Kalinin, A., Thomä, N.H., Sidorovitch, V., Goody, R.S. and Alexandrov, K. (2002). „In vitro assembly, purification, and crystallization of the Rab geranylgeranyl transferase:substrate complex”. Protein Expr. Purif. 25: 23—30. PMID 12071695. 
  6. ^ Gibbs, R.A. (1998). „Prenyl transfer and the enzymes of terpenoid and steroid biosynthesis”. Ур.: Sinnott, M. Comprehensive Biological Catalysis. A Mechanistic Reference. 1. San Diego, CA: Academic Press. стр. 31—118. 

Литература

  • Gibbs, R.A. (1998). „Prenyl transfer and the enzymes of terpenoid and steroid biosynthesis”. Ур.: Sinnott, M. Comprehensive Biological Catalysis. A Mechanistic Reference. 1. San Diego, CA: Academic Press. стр. 31—118. 

Spoljašnje veze