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Spermidin sintaza
Spermidin sintaza
	Spermidin sintaza tetramer, Bacillus subtilis
Identifikatori
EC broj	2.5.1.16
CAS broj	37277-82-0
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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NCBI	proteini

Spermidin sintaza (EC 2.5.1.16, aminopropiltransferaza, putrescinska aminopropiltransferaza, spermidinska sintetaza, SpeE) je enzim sa sistematskim imenom S-adenozilmetioninamin:putrescin 3-aminopropiltransferaza.^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

S-adenozilmetioninamin + putrescin

\rightleftharpoons

5'-S-metil-5'-tioadenozin + spermidin

Ovaj enzim nije identičan sa EC 2.5.1.22, sperminskom sintazom. Enzim sisara je visoko specifičan, dok bakterijski enzim može da koristi druge akceptore i može da sintetizuje spermin.

Reference

^ Hannonen, P., Janne, J. and Raina, A. (1972). „Partial purification and characterization of spermine synthase from rat brain”. Biochim. Biophys. Acta. 289: 225—231. PMID 4564056.
^ Pegg, A.E., Shuttleworth, K. and Hibasami, H. (1981). „Specificity of mammalian spermidine synthase and spermine synthase”. Biochem. J. 197: 315—320. PMID 6798961.
^ Tabor, C.W. (1962). „Propylamine transferase (spermidine synthesis)”. Methods Enzymol. 5: 761—765.
^ Tabor, H. & Tabor, C.W. (1972). „Biosynthesis and metabolism of 1,4-diaminobutane, spermidine, spermine, and related amines”. Adv. Enzymol. Relat. Areas Mol. Biol. 36: 203—268. PMID 4628436.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

Spermidine+synthase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Hannonen, P., Janne, J. and Raina, A. (1972). „Partial purification and characterization of spermine synthase from rat brain”. Biochim. Biophys. Acta. 289: 225—231. PMID 4564056.

[2] Pegg, A.E., Shuttleworth, K. and Hibasami, H. (1981). „Specificity of mammalian spermidine synthase and spermine synthase”. Biochem. J. 197: 315—320. PMID 6798961.

[3] Tabor, C.W. (1962). „Propylamine transferase (spermidine synthesis)”. Methods Enzymol. 5: 761—765.

[4] Tabor, H. & Tabor, C.W. (1972). „Biosynthesis and metabolism of 1,4-diaminobutane, spermidine, spermine, and related amines”. Adv. Enzymol. Relat. Areas Mol. Biol. 36: 203—268. PMID 4628436.

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