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Poli (b-D-manuronat) lijaza
Poli (b-D-manuronat) lijaza
Identifikatori
EC broj	4.2.2.3
CAS broj	9024-15-1
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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Poli (b-D-manuronat) lijaza (EC 4.2.2.3, alginatna lijaza I, alginatna lijaza, alginaza I, alginaza II, alginaza, poli(beta-D-1,4-manuronid) lijaza, aly (gen)) je enzim sa sistematskim imenom poli((1->4)-beta-D-manuronid) lijaza.^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

Eliminativno razlaganje polisaharida koji sadrže beta-D-manuronatne ostatke čime se formiraju oligosaharidi sa 4-dezoksi-alfa-L-eritro-heks-4-enopiranuronozil grupama na njihovim neredukujućim krajevima

Enzim iz bakterija Sphingomonas vrste A1 razlaže alginat.

Reference

^ Davidson, I.W., Lawson, C.J. and Sutherland, I.W. (1977). „An alginate lysate from Azotobacter vinelandii phage”. J. Gen. Microbiol. 98: 223—229. PMID 13144.
^ Nakada, H.I. & Sweeny, P.C. (1967). „Alginic acid degradation by eliminases from abalone hepatopancreas”. J. Biol. Chem. 242: 845—851. PMID 6020438.
^ Preiss, J. & Ashwell, G. (1962). „Alginic acid metabolism in bacteria. I. Enzymatic formation of unsaturated oligosaccharides and 4-deoxy-L-erythro-5-hexoseulose uronic acid”. J. Biol. Chem. 237: 309—316. PMID 14488584.
^ Hashimoto, W., Miyake, O., Momma, K., Kawai, S. and Murata, K. (2000). „Molecular identification of oligoalginate lyase of Sphingomonas sp. strain A1 as one of the enzymes required for complete depolymerization of alginate”. J. Bacteriol. 182: 4572—4577. PMID 10913091.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

Poly(beta-D-mannuronate)+lyase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Davidson, I.W., Lawson, C.J. and Sutherland, I.W. (1977). „An alginate lysate from Azotobacter vinelandii phage”. J. Gen. Microbiol. 98: 223—229. PMID 13144.

[2] Nakada, H.I. & Sweeny, P.C. (1967). „Alginic acid degradation by eliminases from abalone hepatopancreas”. J. Biol. Chem. 242: 845—851. PMID 6020438.

[3] Preiss, J. & Ashwell, G. (1962). „Alginic acid metabolism in bacteria. I. Enzymatic formation of unsaturated oligosaccharides and 4-deoxy-L-erythro-5-hexoseulose uronic acid”. J. Biol. Chem. 237: 309—316. PMID 14488584.

[4] Hashimoto, W., Miyake, O., Momma, K., Kawai, S. and Murata, K. (2000). „Molecular identification of oligoalginate lyase of Sphingomonas sp. strain A1 as one of the enzymes required for complete depolymerization of alginate”. J. Bacteriol. 182: 4572—4577. PMID 10913091.

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