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Hijaluronatna lijaza
Hijaluronatna lijaza
Identifikatori
EC broj	4.2.2.1
CAS broj	37259-53-3
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Hijaluronatna lijaza (EC 4.2.2.1, hijaluronidaza, glukuronaglikozaminoglikanska lijaza, mukinaza) je enzim sa sistematskim imenom hialuronat lijaza.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

Razlaže hijaluronatne lance na beta-D-GalNAc-(1->4)-beta-D-GlcA vezi, čime se polisaharid razlaže do 3-(4-dezoksi-beta-D-gluk-4-enuronozil)-N-acetil-D-glukozamina

Ovaj enzim takođe deluje na hondroitin.

Reference

^ Linker, A., Hoffman, P., Meyer, K., Sampson, P. and Korn, E.D. (1960). „The formation of unsaturated disacharides from mucopoly-saccharides and their cleavage to α-keto acid by bacterial enzymes”. J. Biol. Chem. 235: 3061—3061. PMID 13762462.
^ Meyer, K. & Rapport, M.M. (1952). „Hyaluronidases”. Adv. Enzymol. Relat. Subj. Biochem. 13: 199—236. PMID 14943668.
^ Moran, F., Nasuno, S. and Starr, M.P. (1968). „Extracellular and intracellular polygalacturonic acid trans-eliminases of Erwinia carotovora”. Arch. Biochem. Biophys. 123: 298—306. PMID 5642600.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

Hyaluronate+lyase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Linker, A., Hoffman, P., Meyer, K., Sampson, P. and Korn, E.D. (1960). „The formation of unsaturated disacharides from mucopoly-saccharides and their cleavage to α-keto acid by bacterial enzymes”. J. Biol. Chem. 235: 3061—3061. PMID 13762462.

[2] Meyer, K. & Rapport, M.M. (1952). „Hyaluronidases”. Adv. Enzymol. Relat. Subj. Biochem. 13: 199—236. PMID 14943668.

[3] Moran, F., Nasuno, S. and Starr, M.P. (1968). „Extracellular and intracellular polygalacturonic acid trans-eliminases of Erwinia carotovora”. Arch. Biochem. Biophys. 123: 298—306. PMID 5642600.

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