O-sukcinilbenzoatna sintaza

O-sukcinilbenzoatna sintaza
Identifikatori
EC broj4.2.1.113
CAS broj97089-83-3
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum

O-sukcinilbenzoatna sintaza (EC 4.2.1.113, o-sukcinilbenzojevo kiselinska sintaza, OSB sintaza, OSBS, 2-sukcinilbenzoatna sintaza, MenC) je enzim sa sistematskim imenom (1R,6R)-6-hidroksi-2-sukcinilcikloheksa-2,4-dien-1-karboksilat hidrolijaza (formira 2-sukcinilbenzoat).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

(1R,6R)-6-hidroksi-2-sukcinilcikloheksa-2,4-dien-1-karboksilat 2-sukcinilbenzoat + H2O

Ovaj enzim pripada enolaznoj superfamiliji.

Reference

  1. ^ Sharma, V., Meganathan, R. and Hudspeth, M.E. (1993). „Menaquinone (vitamin K2) biosynthesis: cloning, nucleotide sequence, and expression of the menC gene from Escherichia coli”. J. Bacteriol. 175: 4917—4921. PMID 8335646. 
  2. ^ Klenchin, V.A., Taylor Ringia, E.A., Gerlt, J.A. and Rayment, I. (2003). „Evolution of enzymatic activity in the enolase superfamily: structural and mutagenic studies of the mechanism of the reaction catalyzed by o-succinylbenzoate synthase from Escherichia coli”. Biochemistry. 42: 14427—14433. PMID 14661953. 
  3. ^ Palmer, D.R., Garrett, J.B., Sharma, V., Meganathan, R., Babbitt, P.C. and Gerlt, J.A. (1999). „Unexpected divergence of enzyme function and sequence: "N-acylamino acid racemase" is o-succinylbenzoate synthase”. Biochemistry. 38: 4252—4258. PMID 10194342. 
  4. ^ Thompson, T.B., Garrett, J.B., Taylor, E.A., Meganathan, R., Gerlt, J.A. and Rayment, I. (2000). „Evolution of enzymatic activity in the enolase superfamily: structure of o-succinylbenzoate synthase from Escherichia coli in complex with Mg2+ and o-succinylbenzoate”. Biochemistry. 39: 10662—10676. PMID 10978150. 
  5. ^ Taylor Ringia, E.A., Garrett, J.B., Thoden, J.B., Holden, H.M., Rayment, I. and Gerlt, J.A. (2004). „Evolution of enzymatic activity in the enolase superfamily: functional studies of the promiscuous o-succinylbenzoate synthase from Amycolatopsis”. Biochemistry. 43: 224—229. PMID 14705949. 

Literatura

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