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O-fosfoserin sulfhidrilaza
O-fosfoserin sulfhidrilaza
Identifikatori
EC broj	2.5.1.65
CAS broj	1071505-11-7
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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O-fosfoserin sulfhidrilaza (EC 2.5.1.65, O-fosfoserin(tiol)-lijaza) je enzim sa sistematskim imenom O-fosfo-L-serin:vodonik-sulfid 2-amino-2-karboksietiltransferaza.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

O-fosfo-L-serin + vodonik sulfid

\rightleftharpoons

L-cistein + fosfat

Ovaj enzim je piridoksal-fosfatni protein. Enzim iz Aeropyrum pernix deluje O-fosfo-L-serin i O³-acetil-L-serin, za razliku od enzima EC 2.5.1.47, cistein sintaze, koji deluje samo na O³-acetil-L-serin.

Reference

^ Mino, K. & Ishikawa, K. (2003). „A novel O-phospho-L-serine sulfhydrylation reaction catalyzed by O-acetylserine sulfhydrylase from Aeropyrum pernix K1”. FEBS Lett. 551: 133—138. PMID 12965218.
^ Mino, K. & Ishikawa, K. (2003). „Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1”. J. Bacteriol. 185: 2277—2284. PMID 12644499.
^ Mino, K. & Ishikawa, K. (2003). „Crystallization and preliminary X-ray diffraction analysis of O-acetylserine sulfhydrylase from Aeropyrum pernix K1”. Acta Crystallogr. D Biol. Crystallogr. 59: 338—340. PMID 12554945.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

O-phosphoserine+sulfhydrylase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Mino, K. & Ishikawa, K. (2003). „A novel O-phospho-L-serine sulfhydrylation reaction catalyzed by O-acetylserine sulfhydrylase from Aeropyrum pernix K1”. FEBS Lett. 551: 133—138. PMID 12965218.

[2] Mino, K. & Ishikawa, K. (2003). „Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1”. J. Bacteriol. 185: 2277—2284. PMID 12644499.

[3] Mino, K. & Ishikawa, K. (2003). „Crystallization and preliminary X-ray diffraction analysis of O-acetylserine sulfhydrylase from Aeropyrum pernix K1”. Acta Crystallogr. D Biol. Crystallogr. 59: 338—340. PMID 12554945.

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