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O-fosfo-L-seril-tRNK:Cys-tRNK sintaza
O-fosfo-L-seril-tRNK:Cys-tRNK sintaza
Identifikatori
EC broj	2.5.1.73
CAS broj	1239229-21-0
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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O-fosfo-L-seril-tRNK:Cys-tRNK sintaza (EC 2.5.1.73, SepCysS, Sep-tRNK:Cys-tRNK sintaza) je enzim sa sistematskim imenom O-fosfo-L-seril-tRNKCis:vodonik sulfid 2-aminopropanoat transferaza.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

O-fosfo-L-seril-tRNKCys + sulfid

\rightleftharpoons

L-cisteinil-tRNKCys + fosfat

U organizmima poput Archaeoglobus fulgidus kojima nedostaje enzim EC 6.1.1.16 (cistein---tRNK ligaza) za direktno formiranje Cys-tRNKCys, taj molekul se indirektno obrazuje posredstvom enzima EC 6.1.1.27 (O-fosfoseril-tRNK ligaze) koja ligira O-fosfoserin do tRNKCys, i EC 2.5.1.73, koji konvertuje nastali O-fosfo-L-seril-tRNKCys do Cys-tRNKCys.

Reference

^ Fukunaga, R. & Yokoyama, S. (2007). „Structural insights into the second step of RNA-dependent cysteine biosynthesis in archaea: crystal structure of Sep-tRNA:Cys-tRNA synthase from Archaeoglobus fulgidus”. J. Mol. Biol. 370: 128—141. PMID 17512006.
^ Hauenstein, S.I. & Perona, J.J. (2008). „Redundant synthesis of cysteinyl-tRNA^Cys in Methanosarcina mazei”. J. Biol. Chem. 283: 22007—22017. PMID 18559341.
^ Yuan, J., Palioura, S., Salazar, J.C., Su, D., O'Donoghue, P., Hohn, M.J., Cardoso, A.M., Whitman, W.B. and Soll, D. (2006). „RNA-dependent conversion of phosphoserine forms selenocysteine in eukaryotes and archaea”. Proc. Natl. Acad. Sci. USA. 103: 18923—18927. PMID 17142313.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

O-phospho-L-seryl-tRNA:Cys-tRNA+synthase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Fukunaga, R. & Yokoyama, S. (2007). „Structural insights into the second step of RNA-dependent cysteine biosynthesis in archaea: crystal structure of Sep-tRNA:Cys-tRNA synthase from Archaeoglobus fulgidus”. J. Mol. Biol. 370: 128—141. PMID 17512006.

[2] Hauenstein, S.I. & Perona, J.J. (2008). „Redundant synthesis of cysteinyl-tRNA^Cys in Methanosarcina mazei”. J. Biol. Chem. 283: 22007—22017. PMID 18559341.

[3] Yuan, J., Palioura, S., Salazar, J.C., Su, D., O'Donoghue, P., Hohn, M.J., Cardoso, A.M., Whitman, W.B. and Soll, D. (2006). „RNA-dependent conversion of phosphoserine forms selenocysteine in eukaryotes and archaea”. Proc. Natl. Acad. Sci. USA. 103: 18923—18927. PMID 17142313.

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