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Nikotinat dehidrogenaza
Nikotinat dehidrogenaza
Identifikatori
EC broj	1.17.1.5
CAS broj	2614835
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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NCBI	proteini

Nikotinat dehidrogenaza (EC 1.17.1.5, nikotinsko kiselinska hidroksilaza, nikotinatna hidroksilaza) je enzim sa sistematskim imenom nikotinat:NADP⁺ 6-oksidoreduktaza (hidroksilacija).^[1]^[2]^[3]^[4]^[5]^[6] Ovaj enzim katalizuje sledeću hemijsku reakciju

nikotinat + H₂O + NADP⁺

\rightleftharpoons

6-hidroksinikotinat + NADPH + H⁺

Ovaj enzim je flavoprotein koji sadrži gvožđe nevezano za hem. Enzim ima sposobnost aktiviranja mnoštva nikotinatnih analoga u različitim merama.

Reference

^ Holcenberg, J.S. & Stadtman, E.R. (1969). „Nicotinic acid metabolism. 3. Purification and properties of a nicotinic acid hydroxylase”. J. Biol. Chem. 244: 1194—1203. PMID 4388026.
^ Gladyshev, V.N., Khangulov, S.V. and Stadtman, T.C. (1996). „Properties of the selenium- and molybdenum-containing nicotinic acid hydroxylase from Clostridium barkeri”. Biochemistry. 35: 212—223. PMID 8555176.
^ Gladyshev, V.N., Khangulov, S.V. and Stadtman, T.C. (1994). „Nicotinic acid hydroxylase from Clostridium barkeri: electron paramagnetic resonance studies show that selenium is coordinated with molybdenum in the catalytically active selenium-dependent enzyme”. Proc. Natl. Acad. Sci. USA. 91: 232—236. PMID 8278371.
^ Dilworth, G.L. (1983). „Occurrence of molybdenum in the nicotinic acid hydroxylase from Clostridium barkeri”. Arch. Biochem. Biophys. 221: 565—569. PMID 6838209.
^ Dilworth, G.L. (1982). „Properties of the selenium-containing moiety of nicotinic acid hydroxylase from Clostridium barkeri”. Arch. Biochem. Biophys. 219: 30—38. PMID 7181513.
^ Nagel, M. & Andreesen, J.R. (1990). „Purification and characterization of the molybdoenzymes nicotinate dehydrogenase and 6-hydroxynicotinate dehydrogenase from Bacillus niacini”. Arch. Microbiol. 154: 605—613.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

Nicotinate+dehydrogenase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Holcenberg, J.S. & Stadtman, E.R. (1969). „Nicotinic acid metabolism. 3. Purification and properties of a nicotinic acid hydroxylase”. J. Biol. Chem. 244: 1194—1203. PMID 4388026.

[2] Gladyshev, V.N., Khangulov, S.V. and Stadtman, T.C. (1996). „Properties of the selenium- and molybdenum-containing nicotinic acid hydroxylase from Clostridium barkeri”. Biochemistry. 35: 212—223. PMID 8555176.

[3] Gladyshev, V.N., Khangulov, S.V. and Stadtman, T.C. (1994). „Nicotinic acid hydroxylase from Clostridium barkeri: electron paramagnetic resonance studies show that selenium is coordinated with molybdenum in the catalytically active selenium-dependent enzyme”. Proc. Natl. Acad. Sci. USA. 91: 232—236. PMID 8278371.

[4] Dilworth, G.L. (1983). „Occurrence of molybdenum in the nicotinic acid hydroxylase from Clostridium barkeri”. Arch. Biochem. Biophys. 221: 565—569. PMID 6838209.

[5] Dilworth, G.L. (1982). „Properties of the selenium-containing moiety of nicotinic acid hydroxylase from Clostridium barkeri”. Arch. Biochem. Biophys. 219: 30—38. PMID 7181513.

[6] Nagel, M. & Andreesen, J.R. (1990). „Purification and characterization of the molybdoenzymes nicotinate dehydrogenase and 6-hydroxynicotinate dehydrogenase from Bacillus niacini”. Arch. Microbiol. 154: 605—613.

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