Ovaj enzim je odgovoran za de novo konverziju ribonukleozid difosfata u dezoksiribonukleozid difosfate, što je esencijalno za DNK sintezu i popravku. On sadrži gvožđe. Enzim aktivira ATP, a inhibira ga dATP.
Reference
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^Larsson, A. & Reichard, P. (1966). „Enzymatic synthesis of deoxyribonucleotides. IX. Allosteric effects in the reduction of pyrimidine ribonucleotides by the ribonucleoside diphosphate reductase system of Escherichia coli”. J. Biol. Chem. 241: 2533—2539. PMID5330119.
^Larsson, A. & Reichard, P. (1966). „Enzymatic synthesis of deoxyribonucleotides. X. Reduction of purine ribonucleotides; allosteric behavior and substrate specificity of the enzyme system from Escherichia coli B”. J. Biol. Chem. 241: 2540—2549. PMID5330120.
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