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Karboksipeptidaza C
Karboksipeptidaza C
Identifikatori
EC broj	3.4.16.5
CAS broj	9046-67-7
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Karboksipeptidaza C (EC 3.4.16.5, karboksipeptidaza Y, serinska karboksipeptidaza I, katepsin A, lizozomalni protektivni protein, deamidaza, lizozomalna karboksipeptidaza A, fazeolin) je enzim.^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

Odvajanje C-terminalne aminokiseline sa širokom specifičnošću

Ova karboksipeptidaza optimalno deluje na pH 4.5-6.0. Inhibira je diizopropil fluorofosfat, i senzitivna je na tiol-blokirajuće reagense.

Reference

^ Breddam, K. (1986). „Serine carboxypeptidases. A review”. Carlsberg Res. Commun. 51: 83—128.
^ Valls, L.A., Hunter, C.P., Rothman, J.H. and Stevens, T.H. (1987). „Protein sorting in yeast: the localization determinant of yeast vacuolar carboxypeptidase Y resides in the propeptide”. Cell. 48: 887—897. PMID 3028649.
^ Jackman, H.L., Morris, P.W., Deddish, P.A., Skidgel, R.A. and Erdös, E.G. (1992). „Inactivation of endothelin I by deamidase (lysosomal protective protein)”. J. Biol. Chem. 267: 2872—2875. PMID 1737744.
^ Miller, J.J., Changaris, D.G. and Levy, R.S. (1992). „Purification, subunit structure and inhibitor profile of cathepsin-A”. J. Chromatogr. 627: 153—162. PMID 1487525.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

Carboxypeptidase+C на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Breddam, K. (1986). „Serine carboxypeptidases. A review”. Carlsberg Res. Commun. 51: 83—128.

[2] Valls, L.A., Hunter, C.P., Rothman, J.H. and Stevens, T.H. (1987). „Protein sorting in yeast: the localization determinant of yeast vacuolar carboxypeptidase Y resides in the propeptide”. Cell. 48: 887—897. PMID 3028649.

[3] Jackman, H.L., Morris, P.W., Deddish, P.A., Skidgel, R.A. and Erdös, E.G. (1992). „Inactivation of endothelin I by deamidase (lysosomal protective protein)”. J. Biol. Chem. 267: 2872—2875. PMID 1737744.

[4] Miller, J.J., Changaris, D.G. and Levy, R.S. (1992). „Purification, subunit structure and inhibitor profile of cathepsin-A”. J. Chromatogr. 627: 153—162. PMID 1487525.

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