PROFILPELAJAR.COM

Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Hondroitin-sulfat-ABC eksolijaza
Hondroitin-sulfat-ABC eksolijaza
Identifikatori
EC broj	4.2.2.21
CAS broj	1000607-06-6
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Hondroitin-sulfat-ABC eksolijaza (EC 4.2.2.21, hondroitinaza, hondroitin ABC eliminaza, hondroitinaza ABC, hondroitin ABC lijaza, hondroitin sulfat ABC lijaza, ChS ABC lijaza, hondroitin sulfat ABC eksoeliminaza, hondroitin sulfat ABC eksolijaza, ChS ABC lijaza II) je enzim sa sistematskim imenom hondroitin-sulfat-ABC eksolijaza.^[1]^[2]^[3]^[4]^[5]^[6] Ovaj enzim katalizuje sledeću hemijsku reakciju

Eksolitičko odvajanje Delta4-nezasićenih disaharidnih ostataka sa neredukujućih krajeva polimernih hondroitin/dermatan sulfata i njihovih oligosaharidnih fragmenata.

Ovaj enzim degradira mnoštvo glikozaminoglikana hondroitin-sulfat- i dermatan-sulfatnog tipa.

Reference

^ Yamagata, T., Saito, H., Habuchi, O. and Suzuki, S. (1968). „Purification and properties of bacterial chondroitinases and chondrosulfatases”. J. Biol. Chem. 243: 1523—1535. PMID 5647268.
^ Saito, H., Yamagata, T. and Suzuki, S. (1968). „Enzymatic methods for the determination of small quantities of isomeric chondroitin sulfates”. J. Biol. Chem. 243: 1536—1542. PMID 4231029.
^ Suzuki, S., Saito, H., Yamagata, T., Anno, K., Seno, N., Kawai, Y. and Furuhashi, T. (1968). „Formation of three types of disulfated disaccharides from chondroitin sulfates by chondroitinase digestion”. J. Biol. Chem. 243: 1543—1550. PMID 5647269.
^ Hamai, A., Hashimoto, N., Mochizuki, H., Kato, F., Makiguchi, Y., Horie, K. and Suzuki, S. (1997). „Two distinct chondroitin sulfate ABC lyases. An endoeliminase yielding tetrasaccharides and an exoeliminase preferentially acting on oligosaccharides”. J. Biol. Chem. 272: 9123—9130. PMID 9083041.
^ Huckerby, T.N., Nieduszynski, I.A., Giannopoulos, M., Weeks, S.D., Sadler, I.H. and Lauder, R.M. (2005). „Characterization of oligosaccharides from the chondroitin/dermatan sulfates. ¹H-NMR and ¹³C-NMR studies of reduced trisaccharides and hexasaccharides”. FEBS J. 272: 6276—6286. PMID 16336265.
^ Zhang, Z., Park, Y., Kemp, M.M., Zhao, W., Im, A.R., Shaya, D., Cygler, M., Kim, Y.S. and Linhardt, R.J. (2009). „Liquid chromatography-mass spectrometry to study chondroitin lyase action pattern”. Anal. Biochem. 385: 57—64. PMID 18992215.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

Chondroitin-sulfate-ABC+exolyase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Yamagata, T., Saito, H., Habuchi, O. and Suzuki, S. (1968). „Purification and properties of bacterial chondroitinases and chondrosulfatases”. J. Biol. Chem. 243: 1523—1535. PMID 5647268.

[2] Saito, H., Yamagata, T. and Suzuki, S. (1968). „Enzymatic methods for the determination of small quantities of isomeric chondroitin sulfates”. J. Biol. Chem. 243: 1536—1542. PMID 4231029.

[3] Suzuki, S., Saito, H., Yamagata, T., Anno, K., Seno, N., Kawai, Y. and Furuhashi, T. (1968). „Formation of three types of disulfated disaccharides from chondroitin sulfates by chondroitinase digestion”. J. Biol. Chem. 243: 1543—1550. PMID 5647269.

[4] Hamai, A., Hashimoto, N., Mochizuki, H., Kato, F., Makiguchi, Y., Horie, K. and Suzuki, S. (1997). „Two distinct chondroitin sulfate ABC lyases. An endoeliminase yielding tetrasaccharides and an exoeliminase preferentially acting on oligosaccharides”. J. Biol. Chem. 272: 9123—9130. PMID 9083041.

[5] Huckerby, T.N., Nieduszynski, I.A., Giannopoulos, M., Weeks, S.D., Sadler, I.H. and Lauder, R.M. (2005). „Characterization of oligosaccharides from the chondroitin/dermatan sulfates. ¹H-NMR and ¹³C-NMR studies of reduced trisaccharides and hexasaccharides”. FEBS J. 272: 6276—6286. PMID 16336265.

[6] Zhang, Z., Park, Y., Kemp, M.M., Zhao, W., Im, A.R., Shaya, D., Cygler, M., Kim, Y.S. and Linhardt, R.J. (2009). „Liquid chromatography-mass spectrometry to study chondroitin lyase action pattern”. Anal. Biochem. 385: 57—64. PMID 18992215.

[1]

[2]

[3]

[4]

[5]

[6]