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Homoakonitatna hidrataza
Homoakonitatna hidrataza
Identifikatori
EC broj	4.2.1.36
CAS broj	9030-68-6
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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PMC	članci
PubMed	članci
NCBI	proteini

Homoakonitatna hidrataza (EC 4.2.1.36, homoakonitaza, cis-homoakonitaza, HACN, Lys4, LysF, 2-hidroksibutan-1,2,4-trikarboksilat hidrolijaza) je enzim sa sistematskim imenom (1R,2S)-1-hidroksibutan-1,2,4-trikarboksilat hidrolijaza (formira (Z)-but-1-en-1,2,4-trikarboksilat).^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

(1R,2S)-1-hidroksibutan-1,2,4-trikarboksilat

\rightleftharpoons

(Z)-but-1-en-1,2,4-trikarboksilat + H₂O

Za dejstvo ovog enzima je neophodan [4Fe-4S] klaster.

Reference

^ Strassman, M. & Ceci, L.N. (1966). „Enzymatic formation of cis-homoaconitic acid, an intermediate in lysine biosynthesis in yeast”. J. Biol. Chem. 241: 5401—5407. PMID 5954805.
^ Jia, Y., Tomita, T., Yamauchi, K., Nishiyama, M. and Palmer, D.R. (2006). „Kinetics and product analysis of the reaction catalysed by recombinant homoaconitase from Thermus thermophilus”. Biochem. J. 396: 479—485. PMID 16524361.
^ Zabriskie, T.M. & Jackson, M.D. (2000). „Lysine biosynthesis and metabolism in fungi”. Nat. Prod. Rep. 17: 85—97. PMID 10714900.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

Homoaconitate+hydratase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Strassman, M. & Ceci, L.N. (1966). „Enzymatic formation of cis-homoaconitic acid, an intermediate in lysine biosynthesis in yeast”. J. Biol. Chem. 241: 5401—5407. PMID 5954805.

[2] Jia, Y., Tomita, T., Yamauchi, K., Nishiyama, M. and Palmer, D.R. (2006). „Kinetics and product analysis of the reaction catalysed by recombinant homoaconitase from Thermus thermophilus”. Biochem. J. 396: 479—485. PMID 16524361.

[3] Zabriskie, T.M. & Jackson, M.D. (2000). „Lysine biosynthesis and metabolism in fungi”. Nat. Prod. Rep. 17: 85—97. PMID 10714900.

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