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Heksaprenil difosfat sintaza (geranilgeranil-difosfat specifična)
Heksaprenil difosfat sintaza (geranilgeranil-difosfat specifična)
Identifikatori
EC broj	2.5.1.82
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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PMC	članci
PubMed	članci
NCBI	proteini

Heksaprenil difosfat sintaza (geranilgeranil-difosfat specifična) (EC 2.5.1.82, HexPS, (sve-E) heksaprenil difosfatna sintaza, (sve-trans) heksaprenil difosfatna sintaza, heksaprenil pirofosfatna sintaza, HexPPs, heksaprenil difosfatna sintaza) je enzim sa sistematskim imenom geranilgeranil-difosfat:izopentenil-difosfat transferaza (dodaje 2 izopentenilne jedinice).^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

geranilgeranil difosfat + 2 izopentenil difosfat

\rightleftharpoons

2 difosfat + sve-trans-heksaprenil difosfat

Ovaj enzim preferentno deluje na geranilgeranil difosfat.

Reference

^ Hemmi, H., Ikejiri, S., Yamashita, S. and Nishino, T. (2002). „Novel medium-chain prenyl diphosphate synthase from the thermoacidophilic archaeon Sulfolobus solfataricus”. J. Bacteriol. 184: 615—620. PMID 11790729.
^ Hemmi, H., Noike, M., Nakayama, T. and Nishino, T. (2002). „Change of product specificity of hexaprenyl diphosphate synthase from Sulfolobus solfataricus by introducing mimetic mutations”. Biochem. Biophys. Res. Commun. 297: 1096—1101. PMID 12372398.
^ Sun, H.Y., Ko, T.P., Kuo, C.J., Guo, R.T., Chou, C.C., Liang, P.H. and Wang, A.H. (2005). „Homodimeric hexaprenyl pyrophosphate synthase from the thermoacidophilic crenarchaeon Sulfolobus solfataricus displays asymmetric subunit structures”. J. Bacteriol. 187: 8137—8148. PMID 16291686.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

Hexaprenyl+diphosphate+synthase+(geranylgeranyl-diphosphate+specific) на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Hemmi, H., Ikejiri, S., Yamashita, S. and Nishino, T. (2002). „Novel medium-chain prenyl diphosphate synthase from the thermoacidophilic archaeon Sulfolobus solfataricus”. J. Bacteriol. 184: 615—620. PMID 11790729.

[2] Hemmi, H., Noike, M., Nakayama, T. and Nishino, T. (2002). „Change of product specificity of hexaprenyl diphosphate synthase from Sulfolobus solfataricus by introducing mimetic mutations”. Biochem. Biophys. Res. Commun. 297: 1096—1101. PMID 12372398.

[3] Sun, H.Y., Ko, T.P., Kuo, C.J., Guo, R.T., Chou, C.C., Liang, P.H. and Wang, A.H. (2005). „Homodimeric hexaprenyl pyrophosphate synthase from the thermoacidophilic crenarchaeon Sulfolobus solfataricus displays asymmetric subunit structures”. J. Bacteriol. 187: 8137—8148. PMID 16291686.

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