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Geranilgeranilglicerol-fosfat geranilgeraniltransferaza
Geranilgeranilglicerol-fosfat geranilgeraniltransferaza
Identifikatori
EC broj	2.5.1.42
CAS broj	124650-68-6
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Geranilgeranilglicerol-fosfat geranilgeraniltransferaza (EC 2.5.1.42, geranilgeraniloksiglicerol fosfat geranilgeraniltransferaza, geranilgeraniltransferaza II, (S)-2,3-di-O-geranilgeranilgliceril fosfat sintaza, DGGGP sintaza, DGGGPS) je enzim sa sistematskim imenom geranilgeranil difosfat:sn-3-O-(geranilgeranil)glicerol 1-fosfat geranilgeraniltransferaza.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

geranilgeranil difosfat + sn-3-O-(geranilgeranil)glicerol 1-fosfat

\rightleftharpoons

difosfat + 2,3-bis-O-(geranilgeranil)glicerol 1-fosfat

Ovaj enzim je integralni membranski protein koji posreduje drugu reakciju prenil transfera pri formiranju polarnih membranskih lipida kod arheja. Za njegovo dejstvo su neophodni divalentni metalni katjoni, kao što su Mg²⁺ ili Mn²⁺.

Reference

^ Zhang, D.-L., Daniels, L. and Poulter, C.D. (1990). „Biosynthesis of archaebacterial membranes. Formation of isoprene ethers by a prenyl transfer reaction”. J. Am. Chem. Soc. 112: 1264—1265.
^ Hemmi, H., Shibuya, K., Takahashi, Y., Nakayama, T. and Nishino, T. (2004). „(S)-2,3-Di-O-geranylgeranylglyceryl phosphate synthase from the thermoacidophilic archaeon Sulfolobus solfataricus. Molecular cloning and characterization of a membrane-intrinsic prenyltransferase involved in the biosynthesis of archaeal ether-linked membrane lipids”. J. Biol. Chem. 279: 50197—50203. PMID 15356000.
^ Morii, H., Nishihara, M. and Koga, Y. (2000). „CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase in the methanogenic archaeon Methanothermobacter thermoautotrophicus”. J. Biol. Chem. 275: 36568—36574. PMID 10960477.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

Geranylgeranylglycerol-phosphate+geranylgeranyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Zhang, D.-L., Daniels, L. and Poulter, C.D. (1990). „Biosynthesis of archaebacterial membranes. Formation of isoprene ethers by a prenyl transfer reaction”. J. Am. Chem. Soc. 112: 1264—1265.

[2] Hemmi, H., Shibuya, K., Takahashi, Y., Nakayama, T. and Nishino, T. (2004). „(S)-2,3-Di-O-geranylgeranylglyceryl phosphate synthase from the thermoacidophilic archaeon Sulfolobus solfataricus. Molecular cloning and characterization of a membrane-intrinsic prenyltransferase involved in the biosynthesis of archaeal ether-linked membrane lipids”. J. Biol. Chem. 279: 50197—50203. PMID 15356000.

[3] Morii, H., Nishihara, M. and Koga, Y. (2000). „CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase in the methanogenic archaeon Methanothermobacter thermoautotrophicus”. J. Biol. Chem. 275: 36568—36574. PMID 10960477.

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