Faktor VIII (FVIII) je esencijalni proteinzgrušavanja krvi. On je takođe poznat kao antihemofilički faktor (AHF). Kod ljudi, faktor VIII je Kodiran F8genom.[1][2] Defekti tog gena dovode do hemophilije A, recesivnog X-vezanog koagulacionog poremećaja.[3]
Reference
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^Truett MA, Blacher R, Burke RL, Caput D, Chu C, Dina D, Hartog K, Kuo CH, Masiarz FR, Merryweather JP (1985). „Characterization of the polypeptide composition of human factor VIII:C and the nucleotide sequence and expression of the human kidney cDNA”. DNA. 4 (5): 333—49. PMID3935400. doi:10.1089/dna.1985.4.333.CS1 одржавање: Вишеструка имена: списак аутора (веза)
^Antonarakis SE (1995). „Molecular genetics of coagulation factor VIII gene and hemophilia A”. Thromb. Haemost. 74 (1): 322—8. PMID8578479.
White GC, Shoemaker CB (1989). „Factor VIII gene and hemophilia A”. Blood. 73 (1): 1—12. PMID2491949.
Antonarakis SE, Kazazian HH, Tuddenham EG (1995). „Molecular etiology of factor VIII deficiency in hemophilia A”. Hum. Mutat. 5 (1): 1—22. PMID7728145. doi:10.1002/humu.1380050102.
Lenting PJ, van Mourik JA, Mertens K (1999). „The life cycle of coagulation factor VIII in view of its structure and function”. Blood. 92 (11): 3983—96. PMID9834200.
Saenko EL; Ananyeva N; Kouiavskaia D; et al. (2003). „Molecular defects in coagulation Factor VIII and their impact on Factor VIII function”. Vox Sang. 83 (2): 89—96. PMID12201837. doi:10.1046/j.1423-0410.2002.00183.x.CS1 одржавање: Експлицитна употреба et al. (веза)
Lollar P (2003). „Molecular characterization of the immune response to factor VIII”. Vox Sang. 83. Suppl 1: 403—8. PMID12617176.