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D-prolin reduktaza (ditiol)
D-prolin reduktaza (ditiol)
Identifikatori
EC broj	1.21.4.1
CAS broj	37255-43-9
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IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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D-prolin reduktaza (ditiol) (EC 1.21.4.1, D-proline reductase (dithiol)) je enzim sa sistematskim imenom 5-aminopentanoat:lipoat oksidoreduktaza (ciklizacija).^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

5-aminopentanoat + lipoat

\rightleftharpoons

D-prolin + dihidrolipoat

Reakcija se odviaj u smeru redukcije D-prolina. Drugi ditioli mogu da deluju kao redukujući agensi.

Reference

^ Hodgins, D.S. & Abeles, R.H. (1969). „Studies of the mechanism of action of D-proline reductase: the presence on covalently bound pyruvate and its role in the catalytic process”. Arch. Biochem. Biophys. 130: 274—285. PMID 5778643.
^ Stadtman, T.C. & Elliott, P. (1957). „Studies on the enzymic reduction of amino acids. II. Purification and properties of a D-proline reductase and a proline racemase from Clostridium sticklandii”. J. Biol. Chem. 228: 983—997. PMID 13475375.
^ Kabisch, U.C., Gräntzdörffer, A., Schierhorn, A., Rücknagel, K.P, Andreesen, J.R. and Pich, A. (1999). „Identification of D-proline reductase from Clostridium sticklandii as a selenoenzyme and indications for a catalytically active pyruvoyl group derived from a cysteine residue by cleavage of a proprotein”. J. Biol. Chem. 274: 8445—8454. PMID 10085076.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

D-proline+reductase+(dithiol) на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Hodgins, D.S. & Abeles, R.H. (1969). „Studies of the mechanism of action of D-proline reductase: the presence on covalently bound pyruvate and its role in the catalytic process”. Arch. Biochem. Biophys. 130: 274—285. PMID 5778643.

[2] Stadtman, T.C. & Elliott, P. (1957). „Studies on the enzymic reduction of amino acids. II. Purification and properties of a D-proline reductase and a proline racemase from Clostridium sticklandii”. J. Biol. Chem. 228: 983—997. PMID 13475375.

[3] Kabisch, U.C., Gräntzdörffer, A., Schierhorn, A., Rücknagel, K.P, Andreesen, J.R. and Pich, A. (1999). „Identification of D-proline reductase from Clostridium sticklandii as a selenoenzyme and indications for a catalytically active pyruvoyl group derived from a cysteine residue by cleavage of a proprotein”. J. Biol. Chem. 274: 8445—8454. PMID 10085076.

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