CP 47,497

CP 47,497
IUPAC ime
2-[(1R,3S)-3-hidroksicikloheksil]- 5-(2-metiloktan-2-il)fenol
Pravni status
Pravni status
  • Ilegalan u Nemačkoj i Francuskoj, Klasa B (UK)
Identifikatori
CAS broj70434-82-1 ДаY
70434-92-3 (C8 homolog)
ATC kodnone
PubChemCID 125835
ChEMBLCHEMBL163701 ДаY
Hemijski podaci
FormulaC21H34O2
Molarna masa318,492 g/mol
  • OC1=CC(C(C)(C)CCCCCC)=CC=C1[C@H]2CCC[C@@H](O)C2

CP 47,497 ili (C7)-CP 47,497 je agonist kanabinoidnog receptora, koji je razvilo preduzeće Pfizer tokom 1980-tih.[1] Ovaj materijal ima analgetsko dejstvo i koristi se u naučnim istraživanjima. Ono je potentan CB1 agonist sa Kd vrednošću od 2,1 nM.[2][3][4]

Vidi još

Reference

  1. ^ Weissman A, Milne GM, Melvin LS Jr. Cannabimimetic activity from CP-47,497, a derivative of 3-phenylcyclohexanol. Journal of Pharmacology and Experimental Therapeutics. 1982 Nov;223(2):516-23. PMID 6290642
  2. ^ Shim JY, Welsh WJ, Howlett AC. Homology model of the CB1 cannabinoid receptor: sites critical for nonclassical cannabinoid agonist interaction. Biopolymers. 2003;71(2):169-89. PMID 12767117
  3. ^ Roger Pertwee. Cannabinoids. Handbook of Experimental Pharmacology Volume 168. Springer. ISBN 978-3-540-22565-2.
  4. ^ Little PJ, et al. Pharmacology and stereoselectivity of structurally novel cannabinoids in mice. Journal of Pharmacology and Experimental Therapeutics 1988; 247:1046–1051.

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