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6-Piruvoiltetrahidropterinska sintaza
6-Piruvoiltetrahidropterinska sintaza
Identifikatori
EC broj	4.2.3.12
CAS broj	97089-82-2
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IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
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6-Piruvoiltetrahidropterinska sintaza (EC 4.2.3.12, 2-amino-4-okso-6-((1S,2R)-1,2-dihidroksi-3-trifosfooksipropil)-7,8-dihidroksipteridin trifosfat lijaza, 6-((1S,2R)-1,2-dihidroksi-3-trifosfooksipropil)-7,8-dihidropterin trifosfat-lijaza (formira 6-piruvoil-5,6,7,8-tetrahidropterin)) je enzim sa sistematskim imenom 7,8-dihidroneopterin 3'-trifosfat trifosfat-lijaza (formira 6-piruvoil-5,6,7,8-tetrahidropterin).^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

7,8-dihidroneopterin 3'-trifosfat

\rightleftharpoons

6-piruvoil-5,6,7,8-tetrahidropterin + trifosfat

Ovaj enzim katalizuje trifosfatnu eliminaciju i intramolekularnu redoks reakciju u prisustvu jona Mg²⁺.

Reference

^ Milstien, S., Kaufman, S. (1989). „The biosynthesis of tetrahydrobiopterin in rat brain. Purification and characterization of 6-pyruvoyl-tetrahydrobiopterin(2′-oxo) reductase”. J. Biol. Chem. 264: 8066—8073. PMID 2656673.
^ Thöny, B., Leimbacher, W., Bürgisser, D., Heinzmann, C.W. (1992). „Human 6-pyruvoyl-tetrahydrobiopterin synthase: cDNA cloning and heterologous expression of the recombinant enzyme”. Biochem. Biophys. Res. Commun. 189: 1437—1443. PMID 1282802.
^ Supangat, S., Choi, Y.K., Park, Y.S., Son, D., Han, C.D. and Lee, K.H. (2005). „Expression, purification, crystallization and preliminary X-ray analysis of sepiapterin reductase from Chlorobium tepidum”. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 61: 202—204. PMID 16510994.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

6-pyruvoyltetrahydropterin+synthase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Milstien, S., Kaufman, S. (1989). „The biosynthesis of tetrahydrobiopterin in rat brain. Purification and characterization of 6-pyruvoyl-tetrahydrobiopterin(2′-oxo) reductase”. J. Biol. Chem. 264: 8066—8073. PMID 2656673.

[2] Thöny, B., Leimbacher, W., Bürgisser, D., Heinzmann, C.W. (1992). „Human 6-pyruvoyl-tetrahydrobiopterin synthase: cDNA cloning and heterologous expression of the recombinant enzyme”. Biochem. Biophys. Res. Commun. 189: 1437—1443. PMID 1282802.

[3] Supangat, S., Choi, Y.K., Park, Y.S., Son, D., Han, C.D. and Lee, K.H. (2005). „Expression, purification, crystallization and preliminary X-ray analysis of sepiapterin reductase from Chlorobium tepidum”. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 61: 202—204. PMID 16510994.

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