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3-Hidroksioktanoil-(acil-nosilac-protein) dehidrataza
3-Hidroksioktanoil-(acil-nosilac-protein) dehidrataza
Identifikatori
EC broj	4.2.1.59
CAS broj	9030-85-7
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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PMC	članci
PubMed	članci
NCBI	proteini

3-Hidroksioktanoil-(acil-nosilac-protein) dehidrataza (EC 4.2.1.59, fabZ (gen), fabA (gen), D-3-hidroksioktanoil-(acil nosilac protein) dehidrataza, D-3-hidroksioktanoil-acil nosilac protein dehidrataza, beta-hidroksioktanoil-acil nosilac protein dehidraza, beta-hidroksioktanoil tioestar dehidrataza, beta-hidroksioktanoil-ACP-dehidraza, (3R)-3-hidroksioktanoil-(acil-nosilac-protein) hidrolijaza, (3R)-3-hidroksioktanoil-(acil-nosilac-protein) hidrolijaza (formira okt-2-enoil-(acil-nosilac protein))) je enzim sa sistematskim imenom (3R)-3-hidroksioktanoil-(acil-nosilac protein) hidrolijaza (formira okt-2-enoil-(acil-nosilac protein)).^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

(3R)-3-hidroksiacil-[acil-nosilac protein]

\rightleftharpoons

trans-2-enoil-[acil-nosilac protein] + H₂O

Ovaje enzim je odgovoran za dehidracioni korak masna-kiselinska biosinteze biljki i bakterija.

Reference

^ Mizugaki, M., Swindell, A.C. and Wkil, S.J. (1968). „Intermediate- and long-chain β-hydroxyacyl-ACP dehydrases from E. coli fatty acid synthetase”. Biochem. Biophys. Res. Commun. 33: 520—527. PMID 4881058.
^ Sharma, A., Henderson, B.S., Schwab, J.M. and Smith, J.L. (1990). „Crystallization and preliminary X-ray analysis of β-hydroxydecanoyl thiol ester dehydrase from Escherichia coli”. J. Biol. Chem. 265: 5110—5112. PMID 2180957.
^ Mohan, S., Kelly, T.M., Eveland, S.S., Raetz, C.R. and Anderson, M.S. (1994). „An Escherichia coli gene (FabZ) encoding (3R)-hydroxymyristoyl acyl carrier protein dehydrase. Relation to fabA and suppression of mutations in lipid A biosynthesis”. J. Biol. Chem. 269: 32896—32903. PMID 7806516.
^ Heath, R.J. & Rock, C.O. (1996). „Roles of the FabA and FabZ β-hydroxyacyl-acyl carrier protein dehydratases in Escherichia coli fatty acid biosynthesis”. J. Biol. Chem. 271: 27795—27801. PMID 8910376.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

3-hydroxyacyl-(acyl-carrier-protein)+dehydratase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Mizugaki, M., Swindell, A.C. and Wkil, S.J. (1968). „Intermediate- and long-chain β-hydroxyacyl-ACP dehydrases from E. coli fatty acid synthetase”. Biochem. Biophys. Res. Commun. 33: 520—527. PMID 4881058.

[2] Sharma, A., Henderson, B.S., Schwab, J.M. and Smith, J.L. (1990). „Crystallization and preliminary X-ray analysis of β-hydroxydecanoyl thiol ester dehydrase from Escherichia coli”. J. Biol. Chem. 265: 5110—5112. PMID 2180957.

[3] Mohan, S., Kelly, T.M., Eveland, S.S., Raetz, C.R. and Anderson, M.S. (1994). „An Escherichia coli gene (FabZ) encoding (3R)-hydroxymyristoyl acyl carrier protein dehydrase. Relation to fabA and suppression of mutations in lipid A biosynthesis”. J. Biol. Chem. 269: 32896—32903. PMID 7806516.

[4] Heath, R.J. & Rock, C.O. (1996). „Roles of the FabA and FabZ β-hydroxyacyl-acyl carrier protein dehydratases in Escherichia coli fatty acid biosynthesis”. J. Biol. Chem. 271: 27795—27801. PMID 8910376.

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