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3-Hidroksidekanoil-(acil-nosilac-protein) dehidrataza
3-Hidroksidekanoil-(acil-nosilac-protein) dehidrataza
Identifikatori
EC broj	4.2.1.60
CAS broj	9030-79-9
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

3-Hidroksidekanoil-(acil-nosilac-protein) dehidrataza (EC 4.2.1.60, D-3-hidroksidekanoil-(acil-nosilac protein) dehidrataza, 3-hidroksidekanoil-acil nosilac protein dehidraza, 3-hidroksidekanoil-acil nosilac protein dehidrataza, beta-hidroksidekanoil tioestar dehidraza, beta-hidroksidekanoatna dehidraza, beta-hidroksidekanoil tiol estarska dehidraza, FabA, beta-hidroksiacil-acil nosilac protein dehidrataza, HDDaza, beta-hidroksiacil-ACP dehidraza, (3R)-3-hidroksidekanoil-(acil-nosilac-protein) hidrolijaza) je enzim sa sistematskim imenom (3R)-3-hidroksidekanoil-(acil-nosilac protein) hidrolijaza.^[1]^[2]^[3]^[4]^[5]^[6]^[7] Ovaj enzim katalizuje sledeću hemijsku reakciju

(1) (3R)-3-hidroksidekanoil-[acil-nosilac protein]

\rightleftharpoons

trans-dec-2-enoil-[acil-nosilac protein] + H₂O

(2) (3R)-3-hidroksidekanoil-[acil-nosilac protein]

\rightleftharpoons

cis-dec-3-enoil-[acil-nosilac protein] + H₂O

Ovaj enzim je specifičan za C10 lance.

Reference

^ Kass, L.R., Brock, D.J.H. and Bloch, K. (1967). „β-Hydroxydecanoyl thioester dehydrase. I. Purification and properties”. J. Biol. Chem. 242: 4418—4431. PMID 4863739.
^ Brock, D.J.H., Kass, L.R. and Bloch, K. (1967). „β-Hydroxydecanoyl thioester dehydrase. II. Mode of action”. J. Biol. Chem. 242: 4432—4440. PMID 4863740.
^ Sharma, A., Henderson, B.S., Schwab, J.M. and Smith, J.L. (1990). „Crystallization and preliminary X-ray analysis of β-hydroxydecanoyl thiol ester dehydrase from Escherichia coli”. J. Biol. Chem. 265: 5110—5112. PMID 2180957.
^ Magnuson, K., Jackowski, S., Rock, C.O. and Cronan, J.E., Jr. (1993). „Regulation of fatty acid biosynthesis in Escherichia coli”. Microbiol. Rev. 57: 522—542. PMID 8246839.
^ Bloch, K. (1969). „Enzymatic synthesis of monounsaturated fatty acids”. Acc. Chem. Res. 2: 193—202.
^ Wang, H. & Cronan, J.E. (2004). „Functional replacement of the FabA and FabB proteins of Escherichia coli fatty acid synthesis by Enterococcus faecalis FabZ and FabF homologues”. J. Biol. Chem. 279: 34489—34495. PMID 15194690.
^ Cronan, J.E., Jr. & Rock, C.O. (1996). „Biosynthesis of membrane lipids”. Ур.: Neidhardt, F.C. Escherichia coli and Salmonella: Cellular and Molecular Biology. 1 (2nd изд.). Washington, DC: ASM Press. стр. 612—636.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Литература

Cronan, J.E., Jr. & Rock, C.O. (1996). „Biosynthesis of membrane lipids”. Ур.: Neidhardt, F.C. Escherichia coli and Salmonella: Cellular and Molecular Biology. 1 (2nd изд.). Washington, DC: ASM Press. стр. 612—636.

Spoljašnje veze

3-hydroxydecanoyl-(acyl-carrier-protein)+dehydratase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Kass, L.R., Brock, D.J.H. and Bloch, K. (1967). „β-Hydroxydecanoyl thioester dehydrase. I. Purification and properties”. J. Biol. Chem. 242: 4418—4431. PMID 4863739.

[2] Brock, D.J.H., Kass, L.R. and Bloch, K. (1967). „β-Hydroxydecanoyl thioester dehydrase. II. Mode of action”. J. Biol. Chem. 242: 4432—4440. PMID 4863740.

[3] Sharma, A., Henderson, B.S., Schwab, J.M. and Smith, J.L. (1990). „Crystallization and preliminary X-ray analysis of β-hydroxydecanoyl thiol ester dehydrase from Escherichia coli”. J. Biol. Chem. 265: 5110—5112. PMID 2180957.

[4] Magnuson, K., Jackowski, S., Rock, C.O. and Cronan, J.E., Jr. (1993). „Regulation of fatty acid biosynthesis in Escherichia coli”. Microbiol. Rev. 57: 522—542. PMID 8246839.

[5] Bloch, K. (1969). „Enzymatic synthesis of monounsaturated fatty acids”. Acc. Chem. Res. 2: 193—202.

[6] Wang, H. & Cronan, J.E. (2004). „Functional replacement of the FabA and FabB proteins of Escherichia coli fatty acid synthesis by Enterococcus faecalis FabZ and FabF homologues”. J. Biol. Chem. 279: 34489—34495. PMID 15194690.

[7] Cronan, J.E., Jr. & Rock, C.O. (1996). „Biosynthesis of membrane lipids”. Ур.: Neidhardt, F.C. Escherichia coli and Salmonella: Cellular and Molecular Biology. 1 (2nd изд.). Washington, DC: ASM Press. стр. 612—636.

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