OR51E2

Olfaktorni receptor, familija 51, potfamilija E, član 2
Identifikatori
Simboli	OR51E2; OR51E3P; OR52A2; PSGR
Vanjski ID	OMIM: 611268 MGI: 2157548 HomoloGene: 23713 GeneCards: OR51E2 Gene
Ontologija gena
Molekularna funkcija	• aktivnost G-protein spregnutog receptora • aktivnost olfaktornog receptora
Celularna komponenta	• ćelijska membrana • integralno sa membranom
Biološki proces	• respons na stimulus
Pregled RNK izražavanja
	podaci
Ortolozi

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Olfaktorni receptor 51E2 je protein koji je kod ljudi kodiran OR51E2 genom.^[1]^[2]

Olfaktorni receptori formiraju interakcije sa molekulima mirisa u nosu, čime se inicira neuronski respons koji izaziva percepciju mirisa. Oni su odgovorni za prepoznavanje i G proteinima posredovanu transdukciju mirisnih signala. Proteini olfaktornih receptora su članovi velike familije G protein spregnutih receptora (GPCR). Poput mnogih receptora za neurotransmitere i hormone, olfaktorni receptori imaju strukturu 7-transmembranskog domena. Oni su kodirani genima sa jednim eksonom. Geni olfaktornih receptora su najveća familija genoma. Nomenklatura gena i proteina olfaktornih receptora je nezavisna od drugih organizama.^[2]

Reference

↑ Xu LL, Stackhouse BG, Florence K, Zhang W, Shanmugam N, Sesterhenn IA, Zou Z, Srikantan V, Augustus M, Roschke V, Carter K, McLeod DG, Moul JW, Soppett D, Srivastava S (Dec 2000). „PSGR, a novel prostate-specific gene with homology to a G protein-coupled receptor, is overexpressed in prostate cancer”. Cancer Res 60 (23): 6568–72. PMID 11118034.
↑ ^2,0 ^2,1 „Entrez Gene: OR51E2 olfactory receptor, family 51, subfamily E, member 2”.

Literatura

Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). „Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence” (PDF). Nature 377 (6547 Suppl): 3–174. PMID 7566098.
Xia C, Ma W, Wang F, et al. (2001). „Identification of a prostate-specific G-protein coupled receptor in prostate cancer”. Oncogene 20 (41): 5903–7. DOI:10.1038/sj.onc.1204803. PMID 11593396.
Yuan TT, Toy P, McClary JA, et al. (2002). „Cloning and genetic characterization of an evolutionarily conserved human olfactory receptor that is differentially expressed across species”. Gene 278 (1–2): 41–51. DOI:10.1016/S0378-1119(01)00709-0. PMID 11707321.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Malnic B, Godfrey PA, Buck LB (2004). „The human olfactory receptor gene family”. Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. DOI:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Weng J, Wang J, Cai Y, et al. (2005). „Increased expression of prostate-specific G-protein-coupled receptor in human prostate intraepithelial neoplasia and prostate cancers”. Int. J. Cancer 113 (5): 811–8. DOI:10.1002/ijc.20635. PMID 15499628.
Weng J, Ma W, Mitchell D, et al. (2006). „Regulation of human prostate-specific G-protein coupled receptor, PSGR, by two distinct promoters and growth factors”. J. Cell. Biochem. 96 (5): 1034–48. DOI:10.1002/jcb.20600. PMID 16149059.
Xu LL, Sun C, Petrovics G, et al. (2006). „Quantitative expression profile of PSGR in prostate cancer”. Prostate Cancer Prostatic Dis. 9 (1): 56–61. DOI:10.1038/sj.pcan.4500836. PMID 16231015.
Wang J, Weng J, Cai Y, et al. (2006). „The prostate-specific G-protein coupled receptors PSGR and PSGR2 are prostate cancer biomarkers that are complementary to alpha-methylacyl-CoA racemase”. Prostate 66 (8): 847–57. DOI:10.1002/pros.20389. PMID 16491480.

Povezano

Mirisni receptori

Vanjske veze

MeSH OR51E2+protein,+human

[pmid11118034-1] Xu LL, Stackhouse BG, Florence K, Zhang W, Shanmugam N, Sesterhenn IA, Zou Z, Srikantan V, Augustus M, Roschke V, Carter K, McLeod DG, Moul JW, Soppett D, Srivastava S (Dec 2000). „PSGR, a novel prostate-specific gene with homology to a G protein-coupled receptor, is overexpressed in prostate cancer”. Cancer Res 60 (23): 6568–72. PMID 11118034.

[entrez-2] 2,0 ^2,1 „Entrez Gene: OR51E2 olfactory receptor, family 51, subfamily E, member 2”.

[1]

[2]

OR51E2

Reference

Literatura

Povezano

Vanjske veze

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