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Bakuloviralni protein 3 koji sadrži IAP ponavljanje
	; PDB prikaz baziran na 2uvl.
Dostupne strukture
	2UVL, 3EB5, 3EB6, 3M0A, 3M0D
Identifikatori
Simboli	BIRC3; AIP1; API2; CIAP2; HAIP1; HIAP1; MALT2; MIHC; RNF49; c-IAP2
Vanjski ID	OMIM: 601721 MGI: 1197007 HomoloGene: 899 GeneCards: BIRC3 Gene
Ontologija gena
Molekularna funkcija	• aktivnost ligaze ubikvitinskog proteina; • proteinsko vezivanje; • vezivanje jona cinka;
Celularna komponenta	• jedro; • citoplazma;
Biološki proces	• apoptotički proces; • antiapoptoza; • signalni put receptora na ćelijskoj površini; • regulacija signalnog puta tol-sličnog receptora; • NIK/NF-kapaB kaskada; • regulacija RIG-I signalnog puta;
Pregled RNK izražavanja
	podaci
Ortolozi

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Bakulovirusni protein 3 koji sadrži IAP ponavljanje (cIAP2) je protein koji je kod ljudi kodiran BIRC3 genom.^[1]^[2]

cIAP2 je član familije Inhibitora apoptoze koja inhibira apoptozu putem ometanja aktivacije kaspaze. Ovaj pretein inhibra apoptozu indukovanu serumskom deprivacijom, ali nema uticaja na apoptozu koja proizilazi iz izlaganja menadionu, potentnom induktoru slobodnih radikala. cIAP2 protein sadrži tri BIR domensa UBA domen, CARD domen i RING prst domen. Poznato je nekoliko transkriptnih varijanti ovog proteina.^[3]

Interakcije

Bakulovirusni protein 3 koji sadrži IAP ponavljanje formira interakcije sa TRAF1,^[4]^[5] TRAF2,^[4]^[5]^[6]^[7] RIPK1,^[8] kaspazom-9^[9] i UBE2D2.^[10]

Reference

↑ Liston P, Roy N, Tamai K, Lefebvre C, Baird S, Cherton-Horvat G, Farahani R, McLean M, Ikeda JE, MacKenzie A, Korneluk RG (February 1996). „Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes”. Nature 379 (6563): 349–53. DOI:10.1038/379349a0. PMID 8552191.
↑ Rothe M, Pan MG, Henzel WJ, Ayres TM, Goeddel DV (February 1996). „The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins”. Cell 83 (7): 1243–52. DOI:10.1016/0092-8674(95)90149-3. PMID 8548810.
↑ „Entrez Gene: BIRC3 baculoviral IAP repeat-containing 3”.
↑ ^4,0 ^4,1 Roy, N; Deveraux Q L, Takahashi R, Salvesen G S, Reed J C (December 1997). „The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases”. EMBO J. (ENGLAND) 16 (23): 6914–25. DOI:10.1093/emboj/16.23.6914. ISSN 0261-4189. PMC 1170295. PMID 9384571.
↑ ^5,0 ^5,1 Li, Xiaoming; Yang Yili, Ashwell Jonathan D (March 2002). „TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2”. Nature (England) 416 (6878): 345–7. DOI:10.1038/416345a. ISSN 0028-0836. PMID 11907583.
↑ Uren, A G; Pakusch M, Hawkins C J, Puls K L, Vaux D L (May 1996). „Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors”. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (10): 4974–8. DOI:10.1073/pnas.93.10.4974. ISSN 0027-8424. PMC 39390. PMID 8643514.
↑ Yoneda, T; Imaizumi K, Maeda M, Yui D, Manabe T, Katayama T, Sato N, Gomi F, Morihara T, Mori Y, Miyoshi K, Hitomi J, Ugawa S, Yamada S, Okabe M, Tohyama M (April 2000). „Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein”. J. Biol. Chem. (UNITED STATES) 275 (15): 11114–20. DOI:10.1074/jbc.275.15.11114. ISSN 0021-9258. PMID 10753917.
↑ Bertrand, Mathieu J M; Milutinovic Snezana, Dickson Kathleen M, Ho Wai Chi, Boudreault Alain, Durkin Jon, Gillard John W, Jaquith James B, Morris Stephen J, Barker Philip A (June 2008). „cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination”. Mol. Cell (United States) 30 (6): 689–700. DOI:10.1016/j.molcel.2008.05.014. PMID 18570872.
↑ Deveraux, Q L; Roy N, Stennicke H R, Van Arsdale T, Zhou Q, Srinivasula S M, Alnemri E S, Salvesen G S, Reed J C (April 1998). „IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases”. EMBO J. (ENGLAND) 17 (8): 2215–23. DOI:10.1093/emboj/17.8.2215. ISSN 0261-4189. PMC 1170566. PMID 9545235.
↑ Mace, Peter D; Linke Katrin, Feltham Rebecca, Schumacher Frances-Rose, Smith Clyde A, Vaux David L, Silke John, Day Catherine L (November 2008). „Structures of the cIAP2 RING domain reveal conformational changes associated with ubiquitin-conjugating enzyme (E2) recruitment”. J. Biol. Chem. (United States) 283 (46): 31633–40. DOI:10.1074/jbc.M804753200. ISSN 0021-9258. PMID 18784070.

Literatura

Bertoni F, Cavalli F, Cotter FE, Zucca E (2003). „Genetic alterations underlying the pathogenesis of MALT lymphoma”. Hematol. J. 3 (1): 10–3. DOI:10.1038/sj/thj/6200146. PMID 11960389.
Uren AG, Pakusch M, Hawkins CJ, et al. (1996). „Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors”. Proc. Natl. Acad. Sci. U.S.A. 93 (10): 4974–8. DOI:10.1073/pnas.93.10.4974. PMC 39390. PMID 8643514.
Rajcan-Separovic E, Liston P, Lefebvre C, Korneluk RG (1997). „Assignment of human inhibitor of apoptosis protein (IAP) genes xiap, hiap-1, and hiap-2 to chromosomes Xq25 and 11q22-q23 by fluorescence in situ hybridization”. Genomics 37 (3): 404–6. DOI:10.1006/geno.1996.0579. PMID 8938457.
Roy N, Deveraux QL, Takahashi R, et al. (1998). „The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases”. EMBO J. 16 (23): 6914–25. DOI:10.1093/emboj/16.23.6914. PMC 1170295. PMID 9384571.
Deveraux QL, Roy N, Stennicke HR, et al. (1998). „IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases”. EMBO J. 17 (8): 2215–23. DOI:10.1093/emboj/17.8.2215. PMC 1170566. PMID 9545235.
Young SS, Liston P, Xuan JY, et al.; Xuan  (1999). „Genomic organization and physical map of the human inhibitors of apoptosis: HIAP1 and HIAP2”. Mamm. Genome 10 (1): 44–8. DOI:10.1007/s003359900940. PMID 9892732.
Horrevoets AJ, Fontijn RD, van Zonneveld AJ, et al. (1999). „Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes”. Blood 93 (10): 3418–31. PMID 10233894.
Suzuki H, Motegi M, Akagi T, et al. (1999). „API1-MALT1-MLT is involved in mucosa-associated lymphoid tissue lymphoma with t(11;18)(q21;q21)”. Blood 94 (9): 3270–1. PMID 10610122.
Huang H, Joazeiro CA, Bonfoco E, et al. (2000). „The inhibitor of apoptosis, cIAP2, functions as a ubiquitin-protein ligase and promotes in vitro monoubiquitination of caspases 3 and 7”. J. Biol. Chem. 275 (35): 26661–4. DOI:10.1074/jbc.C000199200. PMID 10862606.
Verhagen AM, Ekert PG, Pakusch M, et al. (2000). „Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins”. Cell 102 (1): 43–53. DOI:10.1016/S0092-8674(00)00009-X. PMID 10929712.
Baens M, Steyls A, Dierlamm J, et al. (2001). „Structure of the MLT gene and molecular characterization of the genomic breakpoint junctions in the t(11;18)(q21;q21) of marginal zone B-cell lymphomas of MALT type”. Genes Chromosomes Cancer 29 (4): 281–91. DOI:10.1002/1098-2264(2000)9999:9999<::AID-GCC1036>3.0.CO;2-I. PMID 11066071.
Werneburg BG, Zoog SJ, Dang TT, et al. (2001). „Molecular characterization of CD40 signaling intermediates”. J. Biol. Chem. 276 (46): 43334–42. DOI:10.1074/jbc.M104994200. PMID 11562359.
Suzuki Y, Imai Y, Nakayama H, et al. (2001). „A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death”. Mol. Cell 8 (3): 613–21. DOI:10.1016/S1097-2765(01)00341-0. PMID 11583623.
Li X, Yang Y, Ashwell JD (2002). „TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2”. Nature 416 (6878): 345–7. DOI:10.1038/416345a. PMID 11907583.
Gordon GJ, Appasani K, Parcells JP, et al. (2002). „Inhibitor of apoptosis protein-1 promotes tumor cell survival in mesothelioma”. Carcinogenesis 23 (6): 1017–24. DOI:10.1093/carcin/23.6.1017. PMID 12082024.
Sharief MK, Noori MA, Zoukos Y (2002). „Reduced expression of the inhibitor of apoptosis proteins in T cells from patients with multiple sclerosis following interferon-beta therapy”. J. Neuroimmunol. 129 (1–2): 224–31. DOI:10.1016/S0165-5728(02)00185-6. PMID 12161039.
Ekedahl J, Joseph B, Grigoriev MY, et al. (2002). „Expression of inhibitor of apoptosis proteins in small- and non-small-cell lung carcinoma cells”. Exp. Cell Res. 279 (2): 277–90. DOI:10.1006/excr.2002.5608. PMID 12243753.

[pmid8552191-1] Liston P, Roy N, Tamai K, Lefebvre C, Baird S, Cherton-Horvat G, Farahani R, McLean M, Ikeda JE, MacKenzie A, Korneluk RG (February 1996). „Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes”. Nature 379 (6563): 349–53. DOI:10.1038/379349a0. PMID 8552191.

[pmid8548810-2] Rothe M, Pan MG, Henzel WJ, Ayres TM, Goeddel DV (February 1996). „The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins”. Cell 83 (7): 1243–52. DOI:10.1016/0092-8674(95)90149-3. PMID 8548810.

[3] „Entrez Gene: BIRC3 baculoviral IAP repeat-containing 3”.

[pmid9384571-4] 4,0 ^4,1 Roy, N; Deveraux Q L, Takahashi R, Salvesen G S, Reed J C (December 1997). „The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases”. EMBO J. (ENGLAND) 16 (23): 6914–25. DOI:10.1093/emboj/16.23.6914. ISSN 0261-4189. PMC 1170295. PMID 9384571.

[pmid11907583-5] 5,0 ^5,1 Li, Xiaoming; Yang Yili, Ashwell Jonathan D (March 2002). „TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2”. Nature (England) 416 (6878): 345–7. DOI:10.1038/416345a. ISSN 0028-0836. PMID 11907583.

[pmid8643514-6] Uren, A G; Pakusch M, Hawkins C J, Puls K L, Vaux D L (May 1996). „Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors”. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (10): 4974–8. DOI:10.1073/pnas.93.10.4974. ISSN 0027-8424. PMC 39390. PMID 8643514.

[pmid10753917-7] Yoneda, T; Imaizumi K, Maeda M, Yui D, Manabe T, Katayama T, Sato N, Gomi F, Morihara T, Mori Y, Miyoshi K, Hitomi J, Ugawa S, Yamada S, Okabe M, Tohyama M (April 2000). „Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein”. J. Biol. Chem. (UNITED STATES) 275 (15): 11114–20. DOI:10.1074/jbc.275.15.11114. ISSN 0021-9258. PMID 10753917.

[pmid18570872-8] Bertrand, Mathieu J M; Milutinovic Snezana, Dickson Kathleen M, Ho Wai Chi, Boudreault Alain, Durkin Jon, Gillard John W, Jaquith James B, Morris Stephen J, Barker Philip A (June 2008). „cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination”. Mol. Cell (United States) 30 (6): 689–700. DOI:10.1016/j.molcel.2008.05.014. PMID 18570872.

[pmid9545235-9] Deveraux, Q L; Roy N, Stennicke H R, Van Arsdale T, Zhou Q, Srinivasula S M, Alnemri E S, Salvesen G S, Reed J C (April 1998). „IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases”. EMBO J. (ENGLAND) 17 (8): 2215–23. DOI:10.1093/emboj/17.8.2215. ISSN 0261-4189. PMC 1170566. PMID 9545235.

[pmid18784070-10] Mace, Peter D; Linke Katrin, Feltham Rebecca, Schumacher Frances-Rose, Smith Clyde A, Vaux David L, Silke John, Day Catherine L (November 2008). „Structures of the cIAP2 RING domain reveal conformational changes associated with ubiquitin-conjugating enzyme (E2) recruitment”. J. Biol. Chem. (United States) 283 (46): 31633–40. DOI:10.1074/jbc.M804753200. ISSN 0021-9258. PMID 18784070.

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