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1-Amino-1,3-dikarboksiciklopentan
Naziv po klasifikaciji	1-Aminociklopentan-1,3-dikarboksilna kiselina
Identifikacija
Abrevijacija	ACPD
CAS registarski broj	39026-63-6 , 56827-69-1 (1R,3S), 111900-32-4 (1S,3R)
PubChem	1310, ; 44381972 (1S), ; 231345 (1R,3R), ; 73537 (1R,3S), ; 104766 (1S,3R), ; 6604704 (1S,3S)
ChemSpider	1270 , 201559 (1R,3R) , 66220 (1R,3S) , 94574 (1S,3R) , 5036967 (1S,3S)
MeSH	1-amino-1,3-dicarboxycyclopentane
ChEMBL	CHEMBL168278
RTECS registarski broj toksičnosti	GY4060000 (1S,3R)
Jmol-3D slike	Slika 1
SMILES
	NC1(CCC(C1)C(O)=O)C(O)=O
InChI
	InChI=1S/C7H11NO4/c8-7(6(11)12)2-1-4(3-7)5(9)10/h4H,1-3,8H2,(H,9,10)(H,11,12) ; Kod: YFYNOWXBIBKGHB-UHFFFAOYSA-N
Svojstva
Molekulska formula	C7H11NO4
Molarna masa	173.17 g mol−1
Agregatno stanje	Beli kristali
Rastvorljivost u vodi	20 g dm-3
Rastvorljivost u etanol	240 mg dm-3
log P	-0,709
pKa	2,112
Baznost (pKb)	11,885
Izoelektrična tačka	2,84
Opasnost
EU-klasifikacija	Xn
R-oznake	R20/21/22, R36/37/38
S-oznake	S26, S36/37
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

1-Amino-1,3-dikarboksiciklopentan (ACPD) je hemijsko jedinjenje koje se vezuje za metabotropni glutamatni receptor (mGluR).^[6] ACPD deluje kao mGluR agonist. On je krut analog neurotransmitera glutamata koji ne aktivira jonotropne glutamatne receptore.^[7] ACPD može da indukuje konvulzije kod neonatalnih pacova.^[8]

Reference

↑ „1-amino-1,3-dicarboxycyclopentane - Compound Summary”. PubChem Compound. USA: National Center for Biotechnology Information. 25. 3. 2005.. Identification and Related Records. Pristupljeno 15. 10. 2011.
↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Schoepp DD, True RA (September 1992). „1S,3R-ACPD-sensitive (metabotropic) [³H]glutamate receptor binding in membranes”. Neurosci. Lett. 145 (1): 100–4. DOI:10.1016/0304-3940(92)90213-Q. PMID 1461560.
↑ Manzoni O, Fagni L, Pin JP, Rassendren F, Poulat F, Sladeczek F, Bockaert J (July 1990). „(trans)-1-amino-cyclopentyl-1,3-dicarboxylate stimulates quisqualate phosphoinositide-coupled receptors but not ionotropic glutamate receptors in striatal neurons and Xenopus oocytes”. Mol. Pharmacol. 38 (1): 1–6. PMID 2164627. ^{[mrtav link]}
↑ McDonald JW, Fix AS, Tizzano JP, Schoepp DD (October 1993). „Seizures and brain injury in neonatal rats induced by 1S,3R-ACPD, a metabotropic glutamate receptor agonist”. J. Neurosci. 13 (10): 4445–55. PMID 8410197.

[1] „1-amino-1,3-dicarboxycyclopentane - Compound Summary”. PubChem Compound. USA: National Center for Biotechnology Information. 25. 3. 2005.. Identification and Related Records. Pristupljeno 15. 10. 2011.

[2] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[3] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[4] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[pmid1461560-6] Schoepp DD, True RA (September 1992). „1S,3R-ACPD-sensitive (metabotropic) [³H]glutamate receptor binding in membranes”. Neurosci. Lett. 145 (1): 100–4. DOI:10.1016/0304-3940(92)90213-Q. PMID 1461560.

[7] Manzoni O, Fagni L, Pin JP, Rassendren F, Poulat F, Sladeczek F, Bockaert J (July 1990). „(trans)-1-amino-cyclopentyl-1,3-dicarboxylate stimulates quisqualate phosphoinositide-coupled receptors but not ionotropic glutamate receptors in striatal neurons and Xenopus oocytes”. Mol. Pharmacol. 38 (1): 1–6. PMID 2164627. ^{[mrtav link]}

[pmid8410197-8] McDonald JW, Fix AS, Tizzano JP, Schoepp DD (October 1993). „Seizures and brain injury in neonatal rats induced by 1S,3R-ACPD, a metabotropic glutamate receptor agonist”. J. Neurosci. 13 (10): 4445–55. PMID 8410197.

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