Canagliflozină

Canagliflozină
Identificare
Număr CAS842133-18-0[1][2]  Modificați la Wikidata
PubChem24812758[3]  Modificați la Wikidata
DrugBankDB08907  Modificați la Wikidata
ChemSpider26333259[4]  Modificați la Wikidata
UNII6S49DGR869[2]  Modificați la Wikidata
KEGGD09592[5]  Modificați la Wikidata
ChEMBLCHEMBL2048484[6]  Modificați la Wikidata
Cod ATCA10BX11[7]  Modificați la Wikidata
SMILES
CC1=C(C=C(C=C1)C2C(C(C(C(O2)CO)O)O)O)CC3=CC=C(S3)C4=CC=C(C=C4)F[3]  Modificați la Wikidata
InChI
InChI=InChI=1S/C24H25FO5S/c1-13-2-3-15(24-23(29)22(28)21(27)19(12-26)30-24)10-16(13)11-18-8-9-20(31-18)14-4-6-17(25)7-5-14/h2-10,19,21-24,26-29H,11-12H2,1H3/t19-,21-,22+,23-,24+/m1/s1[3]  Modificați la Wikidata
Date chimice
FormulăC₂₄H₂₅FO₅S[3]  Modificați la Wikidata
Masă molară444,141 u.a.m.[3]  Modificați la Wikidata
Modifică date / text Consultați documentația formatului

Canagliflozina (cu denumirea comercială Invokana) este un medicament antidiabetic din clasa inhibitorilor SGLT2, fiind utilizat în tratamentul diabetului zaharat de tipul 2.[8][9][10] Calea de administrare disponibilă este cea orală.[8]

Utilizări medicale

Canagliflozina este utilizată în tratamentul diabetului zaharat de tip 2 (non-insulino-dependent), singură (atunci când administrarea de metformină este considerată inadecvată) sau în asociere cu alte antidiabetice:[8][9][10]

sau combinații ale acestora, la pacienții adulți la care nu s-a realizat controlul glicemic adecvat cu dozele maxime tolerate ale acestor tratamente orale.

Reacții adverse

Principalele efecte adverse asociate tratamentului cu canagliflozină sunt: constipație, poliurie, sete, infecții de tract urinar și candidoză (vulvovaginală).[8][10]

Note

  1. ^ a b CAS Common Chemistry, accesat în  
  2. ^ a b c d canagliflozin anhydrous (în engleză), Global Substance Registration System, accesat în  
  3. ^ a b c d e f g h i j k l m n „Canagliflozină”, Canagliflozin (în engleză), PubChem, accesat în  
  4. ^ a b Canagliflozin (în engleză), ChemSpider, accesat în  
  5. ^ a b Canagliflozin (în engleză), ChEMBL, accesat în  
  6. ^ a b CANAGLIFLOZIN (în engleză), ChEMBL, accesat în  
  7. ^ a b Canagliflozin (în engleză), DrugBank,  
  8. ^ a b c d „Canagliflozin”. The American Society of Health-System Pharmacists. Accesat în . 
  9. ^ a b „Canagliflozin”. DrugBank - Canadian Institutes of Health Research. Accesat în . 
  10. ^ a b c „Rezumatul caracteristicilor produsului - Invokana 100 mg comprimate filmate” (PDF). Agenția Europeană a Medicamentului. Accesat în . 

Vezi și


v • d • m
Medicația antidiabetică: insuline și antidiabetice sistemice (cod ATC A10)
Insulină și analogi de insulină
cu acțiune rapidă
cu acțiune de scurtă durată
cu acțiune intermediară
cu acțiune de lungă durată
Antidiabetice orale (*)
Generația 1: Acetohexamidă  • Carbutamidă  • Clorpropamidă  • Tolazamidă  • Tolbutamidă
Generația 2: Glibenclamidă  • Gliclazidă#  • Glimepiridă  • Glipizidă  • Gliquidonă  • Glisoxepidă
Agoniști GLP-1
Inhibitori DPP-4
Inhibitori de SGLT2 (gliflozine)
Inhibitori alfa-glucozidază
Inhibitori de aldoz-reductază
Analogi de amilină
(*) - Agoniștii GLP-1 și pramlintida se administrează injectabil

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