Nonabina

Nonabina
Alerta sobre risco à saúde
Nome IUPAC 7-(1,2-Dimethylheptyl)-2,2-dimethyl-4-(4-pyridinyl)-2H-1-benzopyran-5-ol
Identificadores
Número CAS 16985-03-8
PubChem 71885
ChemSpider 64899
SMILES
Propriedades
Fórmula química C25H33NO2
Massa molar 379.52 g mol-1
Farmacologia
Página de dados suplementares
Estrutura e propriedades n, εr, etc.
Dados termodinâmicos Phase behaviour
Solid, liquid, gas
Dados espectrais UV, IV, RMN, EM
Exceto onde denotado, os dados referem-se a
materiais sob condições normais de temperatura e pressão
Referências e avisos gerais sobre esta caixa.
Alerta sobre risco à saúde.

Nonabina (BRL-4664) é uma droga experimental que é um análogo sintético do THC.[1] Foi estudado na década de 1980 para a prevenção de náuseas e vômitos associados à quimioterapia, mas nunca foi comercializado. Tem fortes efeitos antieméticos, que são equivalentes aos da clorpromazina, e também produz alguns efeitos sedativos leves, juntamente com boca seca e alterações na eletroencefalografia típicas de agonistas canabinoides, mas com mudanças mínimas no humor e na percepção, sugerindo que o potencial de abuso provavelmente é baixo.[2][3]


Referências

  1. ↑ Staquet M, Bron D, Rozencweig M, Kenis Y (1981). «Clinical studies with a THC analog (BRL-4664) in the prevention of cisplatin-induced vomiting». Journal of Clinical Pharmacology. 21: 60S–63S. PMID 7197692. doi:10.1002/j.1552-4604.1981.tb02575.x 
  2. ↑ Archer CB, Amlot PL, Trounce JR. «Antiemetic effect of nonabine in cancer chemotherapy: a double blind study comparing nonabine and chlorpromazine». British Medical Journal. 286: 350–1. PMC 1546960Acessível livremente. PMID 6402096. doi:10.1136/bmj.286.6362.350-a 
  3. ↑ McClelland GR, Sutton JA (1985). «Pilot investigation of the quantitative EEG and clinical effects of ketazolam and the novel antiemetic nonabine in normal subjects». Psychopharmacology. 85: 306–8. PMID 2860687. doi:10.1007/BF00428192 
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