Ketokonazol

Ketokonazol
IUPAC-név
1-[4-[4-[[(2S,4R)-2-(2,4-diklórfenil)-
2-(imidazol-1-ilmetil)-1,3-dioxolán-4-il]metoxi]
fenil]piperazin-1-il]etanon
Kémiai azonosítók
CAS-szám 65277-42-1
PubChem 47576
DrugBank APRD00401
ATC kód J02AB02, D01AC08 G01AF11
Kémiai és fizikai tulajdonságok
Kémiai képlet C26H28Cl2N4O4
Moláris tömeg 531,43 g/mol
Farmakokinetikai adatok
Biohasznosíthatóság változó
Metabolizmus máj
Biológiai
felezési idő
kétszakaszos
  • kezdeti szakasz: 2 óra
  • végső szakasz: 8 óra
Fehérjekötés 84 – 99%
Kiválasztás epe és vese
Terápiás előírások
Jogi státusz POM (UK, oral formulation) (HU)
Terhességi kategória B3 (Au), C (U.S.)
Alkalmazás orális, helyi

A ketokonazol (INN: ketoconazole), mint szintetikus imidazol dioxolán derivátum, hatékony antimikotikus aktivitással rendelkezik a dermatophytonokkal, valamint a sarjadzógombákkal szemben. A ketokonazol tartalmú krém rendszerint nagyon gyors hatást fejt ki bőrviszketéskor, amely általában dermatophyton vagy sarjadzógomba fertőzést követően lép fel. Ez a tüneti javulás már azelőtt megfigyelhető, mielőtt a gyógyulás első jelei mutatkoznának.

A VIII. Magyar Gyógyszerkönyvben Ketoconazolum néven hivatalos.

Védjegyezett nevű készítmények


Read other articles:

Charles G. Dawes Wakil Presiden Amerika Serikat 30Masa jabatan4 Maret 1925 – 4 Maret 1929PresidenCalvin Coolidge PendahuluCalvin CoolidgePenggantiCharles Curtis Informasi pribadiLahir27 Maret 1865Marietta, Washington County, OhioMeninggal23 April 1951 (umur 86)Evanston, IllinoisKebangsaanAmerikaPartai politikPartai RepublikanSuami/istriCaro Blymyer DawesSunting kotak info • L • B Charles Gates Dawes lahir di Marietta, Washington County, Ohio, pada 27 Maret 1865. i...

 

The Right HonourableRishi SunakMPSunak pada 2022 Perdana Menteri Britania RayaPetahanaMulai menjabat 25 Oktober 2022Penguasa monarkiCharles IIIWakilDominic RaabOliver Dowden PendahuluLiz TrussPenggantiPetahanaPemimpin Partai KonservatifPetahanaMulai menjabat 24 Oktober 2022 PendahuluLiz TrussPenggantiPetahanaMenteri Keuangan Britania RayaMasa jabatan13 Februari 2020 – 5 Juli 2022Perdana MenteriBoris Johnson PendahuluSajid JavidPenggantiNadhim ZahawiSekretaris Utama Perbenda...

 

Public television network of Nepal Television channel Nepal Television नेपाल टेलिभिजनCountryNepalNetworkBroadcast television, satellite, optical and onlineHeadquartersSingha Durbar, Kathmandu, NepalProgrammingLanguage(s) Nepali (Primary) Maithili (Secondary) Nepal Bhasa (Regional) English (International) Picture format4:3 (576i, SDTV) 16:9 (1080i, HDTV)OwnershipOwnerGovernment of NepalHistoryLaunchedJanuary 5, 1984 (1984-01-05)LinksWebsitewww.ntv.org.n...

1948 United States Senate election in Wyoming ← 1942 November 2, 1948 1954 →   Nominee Lester C. Hunt Edward V. Robertson Party Democratic Republican Popular vote 57,953 43,527 Percentage 57.11% 42.89% U.S. senator before election Edward V. Robertson Republican Elected U.S. Senator Lester C. Hunt Democratic Elections in Wyoming Federal government Presidential elections 1892 1896 1900 1904 1908 1912 1916 1920 1924 1928 1932 1936 1940 1944 1948 1952 1956 1960 19...

 

American politician George ConnellGeorge Connell with unknown woman during oath taking ceremony87th Mayor of PhiladelphiaIn officeAugust 11, 1939 – January 1, 1940Preceded bySamuel Davis WilsonSucceeded byRobert Eneas LambertonPresident of the Philadelphia City CouncilIn officeJanuary 1936 – August 11, 1939Member of the Philadelphia City CouncilIn office1913 – August 12, 1939 Personal detailsBorn(1871-11-02)November 2, 1871Philadelphia, Pennsylvania, U.S.DiedO...

 

Stimulant drug 4-MethylmethylphenidateLegal statusLegal status CA: Schedule III DE: NpSG (Industrial and scientific use only) UK: Class B Identifiers IUPAC name methyl (2R)-2-(4-methylphenyl)-2-[(2R)-piperidin-2-yl]acetate CAS Number191790-79-1 Y 680996-70-7 (hydrochloride)PubChem CID44296147ChemSpider8281556 YUNII1Y11XUO4EYChemical and physical dataFormulaC15H21NO2Molar mass247.338 g·mol−13D model (JSmol)Interactive image SMILES Cc2ccc(cc2)C(C(=O)OC)C1CCCCN1 ...

Desirae KrawczykKrawczyk di Prancis Terbuka 2019Kebangsaan Amerika SerikatTempat tinggalPalm Desert, CaliforniaLahir11 Januari 1994 (umur 30)Rancho Mirage, California[1]Tinggi170 cm (5 ft 7 in)Tipe pemainKiri (backhand dua tangan)KampusArizona State University (2013–2016)Total hadiahUS$1.594.742TunggalRekor (M–K)40–29 (57.97%)Gelar0Peringkat tertinggiNo. 752 (Oktober 9, 2017)GandaRekor (M–K)199–144 (58.02%)Gelar8Peringkat tertinggiNo. 9 (April 10, 20...

 

2007 Malaysian filmFlower in the PocketDirected byLiew Seng TatWritten byLiew Seng TatProduced byYen San Michelle LoStarringWong Zi JiangLim Ming WeiAmira Nasuha ShahiranJames LeeAzman Md. HasanCinematographyAlbert Hue See LeongRelease date 2007 (2007) Running time97 minutesCountryMalaysiaLanguagesMandarinCantoneseMalayBudgetRM 64,000Box officeRM 11,000 Flower In The Pocket (Chinese: 口袋裏的花) is a 2007 Malaysian independent film written and directed by Liew Seng Tat. The fil...

 

Beatie Deutsch2019Informasi pribadiNama asliברכה דויטשNama lahirBeatrice RabinNama lengkapBeatrice Rose DeutschJulukanSpeedy BeatieKewarganegaraanIsraelLahir29 Agustus 1989 (umur 34)Washington, DC, Amerika SerikatKediamanYerusalem, IsraelTinggi150 cm (4 ft 11 in) OlahragaNegaraIsraelOlahragaAtletik Bracha Beatie Deutsch (lahir 29 Agustus 1989) adalah seorang atlet lari maraton Ortodoks Israel-Amerika.[1] Ia menjadi juara kategori setengah maraton pada...

This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Regular icosahedron – news · newspapers · books · scholar · JSTOR (October 2023) (Learn how and when to remove this message) Polyhedron with 20 regular triangular faces Regular icosahedronTypeGyroelongated bipyramidDeltahedronFaces20Edges30Vertices12Vertex conf...

 

TournaiMunicipalityKatedral Tournai BenderaLambang kebesaranLocation of Tournai Negara BelgiaMasyarakatMasyarakat PrancisDaerahWalloniaProvinsiHainautArrondissementTournaiPemerintahan • Wali KotaRudy Demotte (PS) • Partai penguasaPS-cdHLuas • Total215,34 km2 (8,314 sq mi)Populasi (2018-01-01)[1] • Total69.554 • Kepadatan3,2/km2 (8,4/sq mi)Kode pos7500-7548Kode NIS57081Kode area telepon069Sit...

 

2003 Canadian Grand Prix Race 8 of 16 in the 2003 Formula One World Championship← Previous raceNext race → Race detailsDate 15 June 2003Official name XLI Grand Prix Air CanadaLocation Circuit Gilles Villeneuve, Montreal, Quebec, CanadaCourse Street circuitCourse length 4.361 km (2.710 miles)Distance 70 laps, 305.270 km (189.686 miles)Weather Partly cloudy and mild with temperatures reaching a maximum of 19.3 °C (66.7 °F)Wind speeds up to 12.9 km/h (8.0...

American physicist (1933–2024) Arno Allan PenziasPenzias in 1982Born(1933-04-26)April 26, 1933Munich, Bavaria, GermanyDiedJanuary 22, 2024(2024-01-22) (aged 90)San Francisco, California, U.S.CitizenshipGermany (until 1935)Stateless (1935–1946)United States (from 1946)EducationCity College of New York (BS)Columbia University (MA, PhD)Known forCosmic microwave background radiationSpouse Sherry Levit ​(m. 1996)​Children5AwardsHenry Draper Medal (1977)No...

 

This article uses bare URLs, which are uninformative and vulnerable to link rot. Please consider converting them to full citations to ensure the article remains verifiable and maintains a consistent citation style. Several templates and tools are available to assist in formatting, such as reFill (documentation) and Citation bot (documentation). (August 2022) (Learn how and when to remove this message) Shalom Catholic CommunityComunidade Católica ShalomHeadquarters - Diaconia ShalomAbbreviati...

 

Not to be confused with Tepoztlán. Town and municipality in State of Mexico, MexicoTepotzotlánTown and municipalityTepotzotlánCoordinates: 19°42′58″N 99°13′25″W / 19.71611°N 99.22361°W / 19.71611; -99.22361Country MexicoStateState of MexicoFounded1525Municipal Status1814Government • Municipal PresidentMarcos Márquez Mecado (2006–2009)Area • Municipality208.83 km2 (80.63 sq mi)Elevation (of seat)2,30...

Air branch of the U.S. Marine Corps United States Marine Corps AviationUnited States Marine Corps Aviation emblemActive22 May 1912 - PresentCountryUnited StatesBranchUnited States Marine CorpsTypeNaval aviationPart ofHeadquarters Marine CorpsMilitary unit A Marine Corps CH-53E Super Stallion flies above the USS San Diego (LPD-22) over the Persian Gulf in 2021 The United States Marine Corps Aviation (USMCA) is the aircraft arm of the United States Marine Corps. Aviation units wi...

 

This is a list of diplomatic missions in Paraguay. Currently there are 31 embassies in the capital Asunción. Major cities, namely Ciudad del Este and Encarnación host consular missions. Other countries accredit their embassies in Buenos Aires, Argentina or Brasília, Brazil, on a non-residential basis to Paraguay. This listing excludes honorary consulates, trade missions, and cultural institutes. Map of countries with embassies in Paraguay Diplomatic missions in Asunción Embassies  A...

 

KucintaAlbum studio karya Yana JulioDirilis1 Juni 1998GenrePopLabelAquarius MusikindoKronologi Yana Julio Selamanya Cinta (1995)Selamanya Cinta1995 Kucinta (1998) Jumpa Lagi (2002)Jumpa Lagi2002 Kucinta merupakan sebuah album musik karya Yana Julio. Dirilis pada tahun 1998. Lagu utamanya ialah All I Am. Daftar lagu Kucinta All I Am Menggapai Asa Asmaraku Asmaramu You Hari Bahagia Tiada Ragu Harapan Artikel bertopik album Indonesia ini adalah sebuah rintisan. Anda dapat membantu Wikipedia ...

Algorithm that employs a degree of randomness as part of its logic or procedure Part of a series onProbabilisticdata structures Bloom filter Count sketch Count–min sketch Quotient filter Skip list Random trees Random binary tree Treap Rapidly exploring random tree Related Randomized algorithm HyperLogLog vte Randomized algorithms redirects here. Not to be confused with Algorithmic randomness. A randomized algorithm is an algorithm that employs a degree of randomness as part of its logic or ...

 

炭酸水素塩泉の例、上湯温泉 炭酸水素塩泉(たんさんすいそえんせん)は、掲示用泉質名に基づく温泉の泉質の分類の1種である。療養泉の中の塩類泉に分類される。 泉質の定義 温泉水1 kg中に含まれる水以外の成分が1000 mg以上存在し、そのうち炭酸水素ナトリウム (NaHCO3) の含有量が340 mgを超える温泉。 概要 炭酸水素イオン(HCO3-)を含み、成分分析をする...