הורמון משחרר הורמון גדילה

הורמון משחרר הורמון גדילה
תכונות
נוסחה אמפירית C₂₁₅H₃₅₈N₇₂O₆₆S עריכת הנתון בוויקינתונים
לעריכה בוויקינתונים שמשמש מקור לחלק מהמידע בתבנית

הורמון משחרר הורמון גדילהאנגלית: Growth-hormone-releasing hormone, ובקיצור: GHRH) הוא הורמון משחרר המיוצר בגרעין הקשתי בהיפותלמוס ומשפיע על בלוטת יותרת המוח לייצר ולהפריש הורמון גדילה. גודלו של הורמון זה הוא 44 חומצות אמינו, כאשר החלק הפעיל מתוכן הוא 29 חומצות האמינו הראשונות. ההשפעה של הורמון משחרר הורמון גדילה על ההיפותלמוס מתבטאת הן ברמת ההפרשה, אשר באה לידי ביטוי תוך שניות, והן ברמת ייצור ההורמון, אשר באה לידי ביטוי תוך שעות. ההורמון המשחרר הורמון גדילה נקשר לקולטן המצומד לחלבון G, ודרך המתווך השניוני cAMP הוא מפעיל את הקינאז פרוטאין קינאז A שפועל על שני המסלולים, הפרשה וייצור. ההפרשה תלויה בכניסת סידן, המביאה לדה-פולריזציה של קרום התא ולשחרור בועית המכילות הורמון גדילה, ואילו הייצור תלוי בזרחון ושפעול של גורמי שעתוק כמו CREB, הנכנסים לגרעין התא ומשפיעים על שעתוק הגן להורמון גדילה.

הורמון משחרר הורמון גדילה מופרש באופן דופקי (פולסטילי), דבר אשר מביא גם להפרשה הדופקית של הורמון גדילה. לכך מצטרף הורמון אחר הנוגד את פעולתו של ההורמון המשחרר הורמון גדילה – סומטוסטטין.


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