MASP2

MASP2
Estruturas dispoñibles
PDB	Buscar ortólogos: PDBe, RCSB Lista de códigos PDB 4FXG, 1Q3X, 1SZB, 1ZJK, 3TVJ ;
Identificadores
Nomenclatura	Outros nomes MASP2, MAP19, MASP-2, MASP1P1, sMAP, serina peptidase da lectina que se une ao manano 2, serina protease da lectina que se une ao manano 2, serina protease asociada á MBL 2, MAP-2 ;
Símbolos	MASP2 (HGNC: 6902) MASP2, MAP19, MASP-2, MASP1P1, sMAP, MAP-2
Identificadores; externos	OMIM: 605102 ; MGI: 1330832 ; HomoloGene: 4819 ; EBI: MASP2; GeneCards: Xene MASP2; UniProt: MASP2;
Locus	Cr. 1 p36.22
Ontoloxía Xénica	Referencias: AmiGO / QuickGO
	Referencias: AmiGO / QuickGO
Ortólogos
Especies
Humano	Rato
Entrez
10747	17175
Ensembl
Véxase HS	Véxase MM
UniProt
O00187	Q91WP0
RefSeq; (ARNm)
NM_139208	NM_001003893
RefSeq; (proteína) NCBI
NP_006601	NP_001003893
Localización (UCSC)
Cr. 1:; 11.03 – 11.05 Mb	Cr. 4:; 148.69 – 148.7 Mb
PubMed (Busca)
10747 ;	17175

A serina protease da lectina que se une ao manano 2, tamén chamada serina protease asociada á proteína que se une á manosa 2 (MASP-2) é un encima que nos humanos está codificado no xene MASP2 do cromosoma 1.^[1]^[2]^[3]

Función

Este xene codifica un membro da familia S1 de peptidases de serina proteases. A preproteína codificada é procesada proteoliticamente para xerar as cadeas A e B que se heterodimerizan para formar a protease madura. Esta protease cliva os compoñentes C2 e C4 para xerar a convertase de C3 da vía da lectina do sistema do complemento. A protease tamén exerce un papel na fervenza de coagulación do sangue ao clivar a protrombina para formar trombina.^[1]

A proteína MASP-2 intervén no sistema do complemento. MASP-2 é moi similar á molécula da vía clásica do complemento C1s, e pénsase que teñen en común un antepasado evolutivo. Cando as cabezas que recoñecen carbohidratos da MBL se unen a residuos especificamente dispostos de manosa da superficie do patóxeno, MASP-2 é activada e empeza a clivar os compoñentes do complemento C4 e C2 dando C4a, C4b, C2a e C2b. O complexo C4bC2a é a convertase de C3.

Notas

↑ ^1,0 ^1,1 "Entrez Gene: mannan-binding lectin serine peptidase 2".
↑ Thiel S, Vorup-Jensen T, Stover CM, Schwaeble W, Laursen SB, Poulsen K, Willis AC, Eggleton P, Hansen S, Holmskov U, Reid KB, Jensenius JC (abril de 1997). "A second serine protease associated with mannan-binding lectin that activates complement". Nature 386 (6624): 506–10. Bibcode:1997Natur.386..506T. PMID 9087411. doi:10.1038/386506a0.
↑ Vorup-Jensen T, Jensenius JC, Thiel S (agosto de 1998). "MASP-2, the C3 convertase generating protease of the MBLectin complement activating pathway". Immunobiology 199 (2): 348–57. PMID 9777418. doi:10.1016/S0171-2985(98)80039-9.

Véxase tamén

Outros atigos

Bibliogafía

Petersen SV, Thiel S, Jensenius JC (2001). "The mannan-binding lectin pathway of complement activation: biology and disease association". Mol. Immunol. 38 (2–3): 133–49. PMID 11532276. doi:10.1016/S0161-5890(01)00038-4.
Rajaraman P, Brenner AV, Butler MA, Wang SS, Pfeiffer RM, Ruder AM, Linet MS, Yeager M, Wang Z, Orr N, Fine HA, Kwon D, Thomas G, Rothman N, Inskip PD, Chanock SJ (2009). "Common variation in genes related to innate immunity and risk of adult glioma.". Cancer Epidemiol. Biomarkers Prev. 18 (5): 1651–8. PMC 2771723. PMID 19423540. doi:10.1158/1055-9965.EPI-08-1041.
McGeachie M, Ramoni RL, Mychaleckyj JC, Furie KL, Dreyfuss JM, Liu Y, Herrington D, Guo X, Lima JA, Post W, Rotter JI, Rich S, Sale M, Ramoni MF (2009). "Integrative predictive model of coronary artery calcification in atherosclerosis.". Circulation 120 (24): 2448–54. PMC 2810344. PMID 19948975. doi:10.1161/CIRCULATIONAHA.109.865501.
Gulla KC, Gupta K, Krarup A, Gal P, Schwaeble WJ, Sim RB, O'Connor CD, Hajela K (2010). "Activation of mannan-binding lectin-associated serine proteases leads to generation of a fibrin clot.". Immunology 129 (4): 482–95. PMC 2842495. PMID 20002787. doi:10.1111/j.1365-2567.2009.03200.x.
Cerhan JR, Novak AJ, Fredericksen ZS, Wang AH, Liebow M, Call TG, Dogan A, Witzig TE, Ansell SM, Habermann TM, Kay NE, Slager SL (2009). "Risk of non-Hodgkin lymphoma in association with germline variation in complement genes.". Br. J. Haematol. 145 (5): 614–23. PMC 2820509. PMID 19344414. doi:10.1111/j.1365-2141.2009.07675.x.
Wang Y, Yan J, Shi Y, Li P, Liu C, Ma Q, Yang R, Wang X, Zhu L, Yang X, Cao C (2009). "Lack of association between polymorphisms of MASP2 and susceptibility to SARS coronavirus infection.". BMC Infect. Dis. 9: 51. PMC 2683852. PMID 19405982. doi:10.1186/1471-2334-9-51.
Han S, Lan Q, Park AK, Lee KM, Park SK, Ahn HS, Shin HY, Kang HJ, Koo HH, Seo JJ, Choi JE, Ahn YO, Chanock SJ, Kim H, Rothman N, Kang D (2010). "Polymorphisms in innate immunity genes and risk of childhood leukemia.". Hum. Immunol. 71 (7): 727–30. PMC 2967770. PMID 20438785. doi:10.1016/j.humimm.2010.04.004.
Kocsis A, Kékesi KA, Szász R, Végh BM, Balczer J, Dobó J, Závodszky P, Gál P, Pál G (2010). "Selective inhibition of the lectin pathway of complement with phage display selected peptides against mannose-binding lectin-associated serine protease (MASP)-1 and -2: significant contribution of MASP-1 to lectin pathway activation.". J. Immunol. 185 (7): 4169–78. PMID 20817870. doi:10.4049/jimmunol.1001819. hdl:10831/91219.
Segat L, Milanese M, Pirulli D, Trevisiol C, Lupo F, Salizzoni M, Amoroso A, Crovella S (2009). "Secreted protein acidic and rich in cysteine (SPARC) gene polymorphism association with hepatocellular carcinoma in Italian patients.". J. Gastroenterol. Hepatol. 24 (12): 1840–6. PMID 19817957. doi:10.1111/j.1440-1746.2009.06009.x.
Smithson A, Perello R, Aibar J, Espinosa G, Tassies D, Freire C, Castro P, Suarez B, Lozano F, Nicolas JM (2010). "Genotypes coding for low serum levels of mannose-binding lectin are underrepresented among individuals suffering from noninfectious systemic inflammatory response syndrome.". Clin. Vaccine Immunol. 17 (3): 447–53. PMC 2837953. PMID 20042521. doi:10.1128/CVI.00375-09.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.". Am. J. Hum. Genet. 85 (5): 628–42. PMC 2775832. PMID 19913121. doi:10.1016/j.ajhg.2009.10.014.
Ytting H, Christensen IJ, Steffensen R, Alsner J, Thiel S, Jensenius JC, Hansen U, Nielsen HJ (2011). "Mannan-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) genotypes in colorectal cancer.". Scand. J. Immunol. 73 (2): 122–7. PMID 21198752. doi:10.1111/j.1365-3083.2010.02480.x.
Vallès X, Roca A, Lozano F, Morais L, Suárez B, Casals F, Mandomando I, Sigaúque B, Nhalungo D, Esquinas C, Quintó L, Alonso PL, Torres A (2010). "Serotype-specific pneumococcal disease may be influenced by mannose-binding lectin deficiency.". Eur. Respir. J. 36 (4): 856–63. PMID 20150204. doi:10.1183/09031936.00171409.
de Rooij BJ, van Hoek B, ten Hove WR, Roos A, Bouwman LH, Schaapherder AF, Porte RJ, Daha MR, van der Reijden JJ, Coenraad MJ, Ringers J, Baranski AG, Hepkema BG, Hommes DW, Verspaget HW (2010). "Lectin complement pathway gene profile of donor and recipient determine the risk of bacterial infections after orthotopic liver transplantation.". Hepatology 52 (3): 1100–10. PMID 20593422. doi:10.1002/hep.23782.
Rajaraman P, Brenner AV, Neta G, Pfeiffer R, Wang SS, Yeager M, Thomas G, Fine HA, Linet MS, Rothman N, Chanock SJ, Inskip PD (2010). "Risk of meningioma and common variation in genes related to innate immunity.". Cancer Epidemiol. Biomarkers Prev. 19 (5): 1356–61. PMC 3169167. PMID 20406964. doi:10.1158/1055-9965.EPI-09-1151.
Liu JL, Cao C, Ma QJ (2009). "[Study on interaction between SARS-CoV N and MAP19].". Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 25 (9): 777–9. PMID 19737459.
St Swierzko A, Cedzynski M, Domzalska-Popadiuk I, MacDonald SL, Borkowska-Klos M, Atkinson AP, Szala A, Jopek A, Jensenius JC, Kawakami M, Szczapa J, Matsushita M, Szemraj J, Turner ML, Kilpatrick DC (2009). "Mannan-binding lectin-associated serine protease-2 (MASP-2) in a large cohort of neonates and its clinical associations". Mol. Immunol. 46 (8–9): 1696–701. PMID 19307021. doi:10.1016/j.molimm.2009.02.022.
Vallès X, Sarrias MR, Casals F, Farnós M, Piñer R, Suárez B, Morais L, Mandomando I, Sigaúque B, Roca A, Alonso PL, Torres A, Thielens NM, Lozano F (2009). "Genetic and structural analysis of MBL2 and MASP2 polymorphisms in south-eastern African children.". Tissue Antigens 74 (4): 298–307. PMID 19775369. doi:10.1111/j.1399-0039.2009.01328.x.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S (2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.". Diabetes Care 33 (10): 2250–3. PMC 2945168. PMID 20628086. doi:10.2337/dc10-0452.