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α-L-fucosidase
α-L-fucosidase
Identifiers
EC no.	3.2.1.51
CAS no.	9037-65-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
PMC
Search
PMC	articles
PubMed	articles
NCBI	proteins

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

α-L-Fucosidase
α-L-Fucosidase
	crystal structure of Thermotoga maritima α-fucosidase
Identifiers
Symbol	α
Pfam	PF01120
Pfam clan	CL0058
InterPro	IPR000933
PROSITE	PDOC00324
SCOP2	1hl9 / SCOPe / SUPFAM
CAZy	GH29
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

The enzyme α-L-fucosidase (EC 3.2.1.51) catalyzes the following chemical reaction: an α-L-fucoside + H₂O $\rightleftharpoons$ L-fucose + an alcohol

This enzyme belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is α-L-fucoside fucohydrolase. This enzyme is also called α-fucosidase. It participates in N-glycan degradation and glycan structure degradation.

Deficiency of this enzyme is called fucosidosis.

In CAZy, α-L-fucosidases are found in glycoside hydrolase family 29 and glycoside hydrolase family 95.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1HL8, 1HL9, and 1ODU.

Human medical studies

It was in a recent study by Endreffy, Bjørklund and collaborators (2017) found an association between the activity of α-L-fucosidase-1 (FUCA-1) and chronic autoimmune disorders in children.^[1] This should encourage further research on FUCA-1 as a marker of chronic inflammation and autoimmunity.

References

^ Endreffy I, Bjørklund G, Szerafin L, Urbina MA, Chirumbolo S, Endreffy E. Plasma alpha-L-fucosidase activity in chronic inflammation and autoimmune disorders in a pediatric cohort of hospitalized patients. Immunologic Research 2017. doi: 10.1007/s12026-017-8943-x.