Verucerfont

Verucerfont
Clinical data
Routes of
administration		Oral
ATC code
  • none
Identifiers
  • 3-(4-methoxy-2-methylphenyl)-2,5-dimethyl-N-[(1S)-1-(3-methyl-1,2,4-oxadiazol-5-yl)propyl]pyrazolo[1,5-a]pyrimidin-7-amine
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
ECHA InfoCard100.158.110 Edit this at Wikidata
Chemical and physical data
FormulaC22H26N6O2
Molar mass406.490 g·mol−1
3D model (JSmol)
  • CC[C@@H](c1nc(no1)C)Nc2cc(nc3n2nc(c3c4ccc(cc4C)OC)C)C
  • InChI=1S/C22H26N6O2/c1-7-17(22-24-15(5)27-30-22)25-19-11-12(2)23-21-20(14(4)26-28(19)21)16-9-8-10-18(29-6)13(16)3/h8-11,17,25H,7H2,1-6H3/t17-/m0/s1
  • Key:NZQAFTPOKINLRY-KRWDZBQOSA-N

Verucerfont (GSK-561,679) is a drug developed by GlaxoSmithKline which acts as a CRF-1 antagonist. Corticotropin releasing factor (CRF), also known as Corticotropin releasing hormone, is an endogenous peptide hormone which is released in response to various triggers such as chronic stress, and activates the two corticotropin-releasing hormone receptors CRH-1 and CRH-2. This then triggers the release of corticotropin (ACTH), another hormone which is involved in the physiological response to stress.

Verucerfont blocks the CRH-1 receptor, and so reduces ACTH release following chronic stress. It is under investigation as a potential treatment for alcoholism, as chronic stress is often a factor in both development of alcoholism and relapse in recovering alcoholics. It has shown promising results in animal studies.[1] However, human trials have shown that while the neuroendocrine effects translate from animal models, the alcohol anti-craving effects do not.[2]

See also

References

  1. ^ Zorrilla EP, Heilig M, de Wit H, Shaham Y (March 2013). "Behavioral, biological, and chemical perspectives on targeting CRF(1) receptor antagonists to treat alcoholism". Drug and Alcohol Dependence. 128 (3): 175–86. doi:10.1016/j.drugalcdep.2012.12.017. PMC 3596012. PMID 23294766.
  2. ^ Schwandt ML, Cortes CR, Kwako LE, et al. (April 2016). "The CRF1 Antagonist Verucerfont in Anxious Alcohol-Dependent Women: Translation of Neuroendocrine, But not of Anti-Craving Effects". Neuropsychopharmacology. 41 (12): 2818–2829. doi:10.1038/npp.2016.61. PMC 5061889. PMID 27109623.

Read other articles:

Henry Eugene Abbey

Artikel ini sebatang kara, artinya tidak ada artikel lain yang memiliki pranala balik ke halaman ini.Bantulah menambah pranala ke artikel ini dari artikel yang berhubungan atau coba peralatan pencari pranala.Tag ini diberikan pada Januari 2023. Henry Eugene Abbey. Henry Eugene abbey (1846-1896) adalah manajer teater dan opera yang berletak di gedung Opera metropolitan di kota New York. Henry lahir di Ohio, Akron pada tanggal 27 Juli, 1846.[1] Henry mengelola gedung opera di sana, dan ...

 

Hermann Grassmann

Grassmann beralih ke halaman ini. Untuk marga, lihat Grassmann (marga). Hermann Günther GrassmannHermann Günther GrassmannLahir(1809-04-15)15 April 1809Stettin, Provinsi Pomerania, Kerajaan Prusia (kini Szczecin, Polandia)Meninggal26 September 1877(1877-09-26) (umur 68)Stettin, Kekaisaran JermanAlmamaterUniversitas BerlinPenghargaanPhD (Hon):Universitas Tübingen (1876)Karier ilmiahInstitusiGimnasium Stettin Hermann Günther Grassmann (Jerman: Graßmanncode: de is deprecated , pelafala...

 

Elman Nawendro

Elman Nawendro Inspektur Pussenarhanud TNI Angkatan DaratMasa jabatan27 Juni 2022 – 18 Desember 2023 PendahuluSuryo Tridoso Sapto HandonoPenggantiJama'ah Informasi pribadiLahir18 September 1968 (umur 55)Magelang, Jawa TengahAlma materAkademi Militer (1990)Karier militerPihak IndonesiaDinas/cabang TNI Angkatan DaratMasa dinas1990—sekarangPangkat Brigadir Jenderal TNISatuanArtileri Pertahanan UdaraSunting kotak info • L • B Brigadir Jenderal TNI Elman N...

العلاقات الإيطالية الوسط إفريقية

العلاقات الإيطالية الوسط أفريقية إيطاليا جمهورية أفريقيا الوسطى   إيطاليا   جمهورية أفريقيا الوسطى تعديل مصدري - تعديل   العلاقات الإيطالية الوسط أفريقية هي العلاقات الثنائية التي تجمع بين إيطاليا وجمهورية أفريقيا الوسطى.[1][2][3][4][5] مقارن...

 

Global mental health

International perspective on mental health Global mental health is the international perspective on different aspects of mental health.[1] It is 'the area of study, research and practice that places a priority on improving mental health and achieving equity in mental health for all people worldwide'.[2] There is a growing body of criticism of the global mental health movement, and has been widely criticised as a neo-colonial or missionary project and as primarily a front for p...

 

Twin Cities Pride

Twin Cities PrideParade banner (2012).FrequencyAnnually in JuneLocation(s)Minneapolis, MinnesotaAttendance400,000Websitetcpride.org A large leather pride flag carried in the Twin Cities Pride parade. Twin Cities Pride, also known as Twin Cities GLBT Pride, is a nonprofit organization which runs an annual celebration in the Twin Cities of Minneapolis and St. Paul, Minnesota every June focusing on the LGBT community. The celebration features a pride parade which draws crowds of nearly 400,000 p...

Maria Drobot

Russian politician In this name that follows Eastern Slavic naming customs, the patronymic is Vladimirovna and the family name is Drobot. Maria DrobotМария ДроботDeputy of the 8th State DumaIncumbentAssumed office 19 September 2021 Personal detailsBorn (1982-03-21) 21 March 1982 (age 42)Rostov-on-Don, Russian Soviet Federative Socialist Republic, USSRPolitical partyCommunist Party of the Russian FederationAlma materRostov State University Maria Drobot (Russian: Мар�...

 

Anna Lee Fisher

American astronaut and physician (born 1949) Anna FisherFisher in 2002BornAnna Lee Tingle (1949-08-24) August 24, 1949 (age 74)New York City, New York, U.S.EducationUniversity of California, Los Angeles (BS, MD, MS)AwardsNASA Space Flight Medal (1984)NASA Exceptional Service Medal (1988, 1998)Space careerNASA astronautTime in space7d 23h 45mSelectionNASA Group 8 (1978)MissionsSTS-51-AMission insignia Anna Lee Fisher (née Sims; born August 24, 1949) is an American chemist, emergency...

 

Onde de Kelvin

Cet article est une ébauche concernant la météorologie ou la climatologie. Vous pouvez partager vos connaissances en l’améliorant (comment ?) selon les recommandations des projets correspondants. Pour les articles homonymes, voir onde (homonymie). Une onde de Kelvin est une onde de gravité océanique, ou atmosphérique, de taille caractéristique assez grande pour que la force de Coriolis se fasse ressentir et en présence d'une couche limite (typiquement une côte). Physiquement...

Rapsodi (singel JKT48)

RapsodiSampul CD dan DVD reguler singel ke-21 Rapsodi. Sampul menampilkan seluruh senbatsu singel ke-21 Rapsodi.Singel oleh JKT48Sisi-ARapsodiSisi-BSweet & BitterMenantiMimpi yang Hina - Gesu na YumeSiapa yang Membuat Kita Berdua Bertemu - Dare ga Futari wo Deawaseta no ka?Dirilis 9 Januari 2020 (Kartu Musik) 22 Januari 2020 (Digital download & streaming, video musik Rapsodi) 1 Februari 2020 (streaming, video musik Sweet & Bitter) 29 Februari 2019 (CD+DVD)FormatCD+DVD, Unduh digit...

 

Человек прямоходящий

† Человек прямоходящий Научная классификация Домен:ЭукариотыЦарство:ЖивотныеПодцарство:ЭуметазоиБез ранга:Двусторонне-симметричныеБез ранга:ВторичноротыеТип:ХордовыеПодтип:ПозвоночныеИнфратип:ЧелюстноротыеНадкласс:ЧетвероногиеКлада:АмниотыКлада:Синапсиды�...

 

A and B Loop

Streetcar circle route in Portland, Oregon, U.S. A and B LoopA streetcar operating the B Loop route and crossing the Broadway Bridge in 2016OverviewOther name(s)Portland Streetcar Loop Project[1][2]Central Loop Line (2012–2015)StatusOperationalOwnerCity of PortlandLocalePortland, Oregon, U.S.Stations52ServiceTypeStreetcarSystemPortland StreetcarServices2Operator(s)Portland Streetcar, Inc.TriMetDaily ridershipA Loop: 1,541B Loop: 1,369(Weekday, August 2022)[3]HistoryO...

Hebe Haven

View of Hebe Haven and Pak Sha Wan Peninsula (centre). Hebe Haven and Buffalo Hill when viewed from a hill on Pak Sha Wan Peninsula. Hiram's Highway at Kau Sai San Tsuen. Tin Hau Temple in Nam Wai. Hebe Haven, also known as Pak Sha Wan (Chinese: 白沙灣; lit. 'White Sand Bay'), is a harbour on the south shore of Sai Kung Peninsula in Hong Kong. The harbour has one opening to Port Shelter in its south. The Pak Sha Wan Peninsula, spanning south from Tsiu Hang (蕉坑) hugs the Heb...

 

Venticano

VenticanoKomuneComune di VenticanoLokasi Venticano di Provinsi AvellinoNegaraItaliaWilayah CampaniaProvinsiAvellino (AV)Luas[1] • Total14,16 km2 (5,47 sq mi)Ketinggian[2]375 m (1,230 ft)Populasi (2016)[3] • Total2.532 • Kepadatan180/km2 (460/sq mi)Zona waktuUTC+1 (CET) • Musim panas (DST)UTC+2 (CEST)Kode pos83030Kode area telepon0825Situs webhttp://www.comune.venticano.av.it Venticano ad...

 

Gymnastics at the 2008 Summer Olympics – Qualification

Main article: Gymnastics at the 2008 Summer Olympics Qualification Summary * Artistic Gymnastics, NOCs with 6 entered athletes may also enter the team competition. Nation Artistic Rhythmic Trampoline Total Men Women Individual Group Men Women  Australia 1 6 1 1 9  Austria 1 1  Azerbaijan 2 6 8  Belarus 6 1 2 6 1 1 17  Belgium 1 1 2  Brazil 1 6 6 13  Bulgaria 1 1 2 6 10  Canada 6 2 1 1 2 12  Cape Verde 1 1  China 6 6 1 6 2 2 23  Colombia ...

Athletics at the 2010 Commonwealth Games – Men's 800 metres

Athletics at the2010 Commonwealth GamesTrack events100 mmenwomen200 mmenwomen400 mmenwomen800 mmenwomen1500 mmenwomen5000 mmenwomen10,000 mmenwomen100 m hurdleswomen110 m hurdlesmen400 m hurdlesmenwomen3000 msteeplechasemenwomen4×100 m relaymenwomen4×400 m relaymenwomenRoad eventsMarathonmenwomen20 km walkmenwomenField eventsHigh jumpmenwomenPole vaultmenwomenLong jumpmenwomenTriple jumpmenwomenShot putmenwomenDiscus throwmenwomenHammer throwmenwomenJavelin throwmenwomenCombined eventsHept...

 

R.B.I. Baseball

Baseball video game series This article is about the series. For the first game in the series, see Pro Baseball: Family Stadium. This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: R.B.I. Baseball – news · newspapers · books · scholar · JSTOR (February 2011) (Learn how and when to remove this message) Video game...

 

Drapeau de l'Inde

Vous lisez un « bon article » labellisé en 2007. Cette page contient des caractères d'alphasyllabaires indiens. En cas de problème, consultez Aide:Unicode. Drapeau de l'Inde Drapeau de l'Inde. Utilisation Caractéristiques Proportions 2:3 Adoption 22 juillet 1947 Éléments 3 bandes horizontales safran, blanche et verte, avec au centre une roue bleu marine modifier  Le pavillon civil, reprenant le Red Ensign britannique. Le pavillon militaire, reprenant le White Ensign br...

Fußball-Club Augsburg 1907 2019-2020

Voce principale: Fußball-Club Augsburg 1907. Fußball-Club Augsburg 1907Stagione 2019-2020Sport calcio Squadra Augusta Allenatore Martin Schmidt (1ª-25ª) Heiko Herrlich (26ª-34ª) All. in seconda Jonas Scheuermann Tobias Zellner Bundesliga15º posto Coppa di GermaniaPrimo turno Maggiori presenzeCampionato: Vargas, Niederlechner (33)Totale: Niederlechner (34) Miglior marcatoreCampionato: Niederlechner (13)Totale: Niederlechner (13) StadioWWK Arena Maggior numero di spettatori30 ...

 

新庄嘉章

この記事は検証可能な参考文献や出典が全く示されていないか、不十分です。 出典を追加して記事の信頼性向上にご協力ください。（このテンプレートの使い方）出典検索?: 新庄嘉章 – ニュース · 書籍 · スカラー · CiNii · J-STAGE · NDL · dlib.jp · ジャパンサーチ · TWL (2011年7月) 1948年 ポータル 文学 新庄 嘉章（しんじょう �...