Type II collagen

collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital)
Identifiers
SymbolCOL2A1
Alt. symbolsSEDC
NCBI gene1280
HGNC2200
OMIM120140
RefSeqNM_001844
UniProtP02458
Other data
LocusChr. 12 q13.11-q13.2
Search for
StructuresSwiss-model
DomainsInterPro

Type II collagen is the basis for hyaline cartilage, including the articular cartilages at joint surfaces. It is formed by homotrimers of collagen, type II, alpha 1 chains.

It makes up 50% of all protein in cartilage and 85–90% of collagen of articular cartilage.

Type II collagen is organised into fibrils. This fibrillar network of collagen allows the cartilage to entrap the proteoglycan aggregate, as well as providing tensile strength to the tissue. Oral administration of native type II collagen induces oral tolerance to pathological immune responses and may be useful in arthritis.[1][2]

See also

References

  1. ^ Park KS, Park MJ, Cho ML, Kwok SK, Ju JH, Ko HJ, Park SH, Kim HY (2009). "Type II collagen oral tolerance; mechanism and role in collagen-induced arthritis and rheumatoid arthritis". Modern Rheumatology. 19 (6): 581–9. doi:10.1007/s10165-009-0210-0. PMID 19697097. S2CID 207061498.
  2. ^ Bakilan F, Armagan O, Ozgen M, Tascioglu F, Bolluk O, Alatas O (June 2016). "Effects of Native Type II Collagen Treatment on Knee Osteoarthritis: A Randomized Controlled Trial". The Eurasian Journal of Medicine. 48 (2): 95–101. doi:10.5152/eurasianjmed.2015.15030. PMC 4970562. PMID 27551171.
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