Tetrahymanol synthase

Tetrahymanol synthase
Identifiers
EC no.4.2.1.123
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
PubMedarticles
NCBIproteins

Tetrahymanol synthase (EC 4.2.1.123, squalene tetrahymanol cyclase) is an enzyme with systematic name squalene hydro-lyase (tetrahymanol forming).[1][2] This enzyme catalyses the following chemical reaction

tetrahymanol squalene + H2O

The reaction occurs in the reverse direction.

This enzyme is isolated from Tetrahymena protozoans.

References

  1. ^ Saar J, Kader JC, Poralla K, Ourisson G (September 1991). "Purification and some properties of the squalene-tetrahymanol cyclase from Tetrahymena thermophila". Biochimica et Biophysica Acta (BBA) - General Subjects. 1075 (1): 93–101. doi:10.1016/0304-4165(91)90080-z. PMID 1892870.
  2. ^ Giner JL, Rocchetti S, Neunlist S, Rohmer M, Arigoni D (June 2005). "Detection of 1,2-hydride shifts in the formation of euph-7-ene by the squalene-tetrahymanol cyclase of Tetrahymena pyriformis". Chemical Communications (24): 3089–91. doi:10.1039/b504300j. PMID 15959594.