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TRA
Identifiers
Aliases	TRA, IMD7, TCRA, TRA@, TRAC, T-cell receptor alpha locus, TCRD, T cell receptor alpha locus
External IDs	GeneCards: TRA; OMA:TRA - orthologs
Orthologs
	6955
	n/a
	n/a
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	P0DSE1
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	Wikidata
View/Edit Human

T-cell receptor alpha locus is a protein that in humans is encoded by the TRA gene, also known as TCRA or TRA@.^[2]^[3]^[4] It contributes the alpha chain to the larger TCR protein (T-cell receptor).

References

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Erikson J, Williams DL, Finan J, Nowell PC, Croce CM (Sep 1985). "Locus of the alpha-chain of the T-cell receptor is split by chromosome translocation in T-cell leukemias". Science. 229 (4715): 784–6. Bibcode:1985Sci...229..784E. doi:10.1126/science.3875152. PMID 3875152.
^ Rabbitts TH, Lefranc MP, Stinson MA, Sims JE, Schroder J, Steinmetz M, Spurr NL, Solomon E, Goodfellow PN (Oct 1985). "The chromosomal location of T-cell receptor genes and a T cell rearranging gene: possible correlation with specific translocations in human T cell leukaemia". EMBO J. 4 (6): 1461–5. doi:10.1002/j.1460-2075.1985.tb03803.x. PMC 554368. PMID 3875483.
^ "Entrez Gene: TRA@ T cell receptor alpha locus".

Kenwrick S, Levinson B, Taylor S, et al. (1993). "Isolation and sequence of two genes associated with a CpG island 5' of the factor VIII gene". Hum. Mol. Genet. 1 (3): 179–86. doi:10.1093/hmg/1.3.179. PMID 1303175.
Suzuki CK, Bonifacino JS, Lin AY, et al. (1991). "Regulating the retention of T-cell receptor alpha chain variants within the endoplasmic reticulum: Ca(2+)-dependent association with BiP". J. Cell Biol. 114 (2): 189–205. doi:10.1083/jcb.114.2.189. PMC 2289081. PMID 1649196.
Travis A, Amsterdam A, Belanger C, Grosschedl R (1991). "LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected]". Genes Dev. 5 (5): 880–94. doi:10.1101/gad.5.5.880. PMID 1827423.
Koning F, Maloy WL, Coligan JE (1990). "The implications of subunit interactions for the structure of the T cell receptor-CD3 complex". Eur. J. Immunol. 20 (2): 299–305. doi:10.1002/eji.1830200211. PMID 2138083. S2CID 2180901.
Dyer MJ (1989). "T-cell receptor delta/alpha rearrangements in lymphoid neoplasms". Blood. 74 (3): 1073–83. doi:10.1182/blood.V74.3.1073.1073. PMID 2546634.
Chilson OP, Kelly-Chilson AE (1989). "Mitogenic lectins bind to the antigen receptor on human lymphocytes". Eur. J. Immunol. 19 (2): 389–96. doi:10.1002/eji.1830190225. PMID 2703017. S2CID 22340836.
Yanagi Y, Chan A, Chin B, et al. (1985). "Analysis of cDNA clones specific for human T cells and the alpha and beta chains of the T-cell receptor heterodimer from a human T-cell line". Proc. Natl. Acad. Sci. U.S.A. 82 (10): 3430–4. Bibcode:1985PNAS...82.3430Y. doi:10.1073/pnas.82.10.3430. PMC 397789. PMID 3873654.
Sim GK, Yagüe J, Nelson J, et al. (1985). "Primary structure of human T-cell receptor alpha-chain". Nature. 312 (5996): 771–5. doi:10.1038/312771a0. PMID 6440030. S2CID 4350315.
Kearse KP, Roberts JL, Singer A (1995). "TCR alpha-CD3 delta epsilon association is the initial step in alpha beta dimer formation in murine T cells and is limiting in immature CD4+ CD8+ thymocytes". Immunity. 2 (4): 391–9. doi:10.1016/1074-7613(95)90147-7. PMID 7719941.
Manolios N, Kemp O, Li ZG (1994). "The T cell antigen receptor alpha and beta chains interact via distinct regions with CD3 chains". Eur. J. Immunol. 24 (1): 84–92. doi:10.1002/eji.1830240114. PMID 8020575. S2CID 85378646.
Bagga R, Emerson BM (1997). "An HMG I/Y-containing repressor complex and supercoiled DNA topology are critical for long-range enhancer-dependent transcription in vitro". Genes Dev. 11 (5): 629–39. doi:10.1101/gad.11.5.629. PMID 9119227.
San José E, Sahuquillo AG, Bragado R, Alarcón B (1998). "Assembly of the TCR/CD3 complex: CD3 epsilon/delta and CD3 epsilon/gamma dimers associate indistinctly with both TCR alpha and TCR beta chains. Evidence for a double TCR heterodimer model". Eur. J. Immunol. 28 (1): 12–21. doi:10.1002/(SICI)1521-4141(199801)28:01<12::AID-IMMU12>3.0.CO;2-9. PMID 9485181. S2CID 85318973.
Ding YH, Smith KJ, Garboczi DN, et al. (1998). "Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids". Immunity. 8 (4): 403–11. doi:10.1016/S1074-7613(00)80546-4. PMID 9586631.
Kirchgessner H, Dietrich J, Scherer J, et al. (2001). "The Transmembrane Adaptor Protein Trim Regulates T Cell Receptor (Tcr) Expression and Tcr-Mediated Signaling via an Association with the Tcr ζ Chain". J. Exp. Med. 193 (11): 1269–84. doi:10.1084/jem.193.11.1269. PMC 2193385. PMID 11390434.
Shelton JG, Gülland S, Nicolson K, et al. (2001). "Importance of the T cell receptor alpha-chain transmembrane distal region for assembly with cognate subunits". Mol. Immunol. 38 (4): 259–65. doi:10.1016/S0161-5890(01)00062-1. PMID 11566319.
Pietra G, Romagnani C, Falco M, et al. (2002). "The analysis of the natural killer-like activity of human cytolytic T lymphocytes revealed HLA-E as a novel target for TCR alpha/beta-mediated recognition". Eur. J. Immunol. 31 (12): 3687–93. doi:10.1002/1521-4141(200112)31:12<3687::AID-IMMU3687>3.0.CO;2-C. PMID 11745389.
Hennecke J, Wiley DC (2002). "Structure of a Complex of the Human α/β T Cell Receptor (TCR) HA1.7, Influenza Hemagglutinin Peptide, and Major Histocompatibility Complex Class II Molecule, HLA-DR4 (DRA0101 and DRB10401): Insight into TCR Cross-Restriction and Alloreactivity". J. Exp. Med. 195 (5): 571–81. doi:10.1084/jem.20011194. PMC 2193773. PMID 11877480.
García P, Llano M, de Heredia AB, et al. (2002). "Human T cell receptor-mediated recognition of HLA-E". Eur. J. Immunol. 32 (4): 936–44. doi:10.1002/1521-4141(200204)32:4<936::AID-IMMU936>3.0.CO;2-M. PMID 11920559.

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[1] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3875152-2] Erikson J, Williams DL, Finan J, Nowell PC, Croce CM (Sep 1985). "Locus of the alpha-chain of the T-cell receptor is split by chromosome translocation in T-cell leukemias". Science. 229 (4715): 784–6. Bibcode:1985Sci...229..784E. doi:10.1126/science.3875152. PMID 3875152.

[pmid3875483-3] Rabbitts TH, Lefranc MP, Stinson MA, Sims JE, Schroder J, Steinmetz M, Spurr NL, Solomon E, Goodfellow PN (Oct 1985). "The chromosomal location of T-cell receptor genes and a T cell rearranging gene: possible correlation with specific translocations in human T cell leukaemia". EMBO J. 4 (6): 1461–5. doi:10.1002/j.1460-2075.1985.tb03803.x. PMC 554368. PMID 3875483.

[entrez-4] "Entrez Gene: TRA@ T cell receptor alpha locus".

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TRA (gene)

References

Further reading