Tra (gene)

For the T-cell receptor alpha locus gene, see TRA (gene).
Transformer
Identifiers
OrganismDrosophila melanogaster
Symboltra
Alt. symbolsCG16724; Dmel\CG16724; Dmtra
Entrez39849
RefSeq (mRNA)NM_079390.3
RefSeq (Prot)NP_524114.1
UniProtP11596
Other data
Chromosome3L: 16.58 - 16.58 Mb
Search for
StructuresSwiss-model
DomainsInterPro
Fruit fly transformer
Identifiers
SymbolTransformer
PfamPF06495
InterProIPR010519
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
Alternative splicing of dsx pre-mRNA. Tra2 is a transformer protein; the gene is involved in the regulation of sex determination in many insects.[1]
Transformer-2
Identifiers
OrganismDrosophila melanogaster
Symboltra2
UniProtP19018
Search for
StructuresSwiss-model
DomainsInterPro

Female-specific protein transformer is a protein that in Drosophila melanogaster is encoded by the tra gene. Unlike the related tra2 protein, it is only produced in females.

The transformer protein controls female somatic sexual differentiation.[2][3] The protein contains an RNA recognition motif. It controls the alternative splicing of the fly sex determination gene doublesex.[1]

References

  1. ^ a b Verhulst EC, van de Zande L, Beukeboom LW (August 2010). "Insect sex determination: it all evolves around transformer" (PDF). Current Opinion in Genetics & Development. 20 (4): 376–83. doi:10.1016/j.gde.2010.05.001. hdl:11370/2174764d-bd1b-4e1f-b142-90aced0c3e55. PMID 20570131. S2CID 205003182.
  2. ^ Boggs RT, Gregor P, Idriss S, Belote JM, McKeown M (August 1987). "Regulation of sexual differentiation in D. melanogaster via alternative splicing of RNA from the transformer gene". Cell. 50 (5): 739–47. doi:10.1016/0092-8674(87)90332-1. PMID 2441872. S2CID 33918630.
  3. ^ Li H, Bingham PM (October 1991). "Arginine/serine-rich domains of the su(wa) and tra RNA processing regulators target proteins to a subnuclear compartment implicated in splicing". Cell. 67 (2): 335–42. doi:10.1016/0092-8674(91)90185-2. PMID 1655279. S2CID 20307555.
Stub icon

This protein-related article is a stub. You can help Wikipedia by expanding it.