In enzymology, a succinylglutamate-semialdehyde dehydrogenase (EC 1.2.1.71) is an enzyme that catalyzes the chemical reaction

N-succinyl-L-glutamate 5-semialdehyde + NAD⁺ + H₂O ${\displaystyle \rightleftharpoons }$ N-succinyl-L-glutamate + NADH + 2 H⁺

The 3 substrates of this enzyme are N-succinyl-L-glutamate 5-semialdehyde, NAD⁺, and H₂O, whereas its 3 products are N-succinyl-L-glutamate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is N-succinyl-L-glutamate 5-semialdehyde:NAD+ oxidoreductase. Other names in common use include succinylglutamic semialdehyde dehydrogenase, N-succinylglutamate 5-semialdehyde dehydrogenase, SGSD, AruD, and AstD. This enzyme participates in arginine and proline metabolism.

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